Search results for: Michael Koller

Items from 1 to 20 out of 125 results

article

Early childhood allergy prevention behaviors: Trends in Germany from 2015 to 2020

Maja Pawellek, Angela Köninger, Michael Melter, Michael Kabesch, more

Pediatric Allergy and Immunology > 34 > 4 > n/a - n/a

article

Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

Truong‐Thanh Pham, Diego O. Andrey, Susanne Stampf, Sara H. Burkhard, more

American Journal of Transplantation > 22 > 12 > 3031 - 3046

Bone and joint infection (BJI) epidemiology and outcomes in solid organ transplant recipients (SOTr) remain largely unknown. We aim to describe BJI in a multi‐center cohort of SOTr (Swiss Transplant Cohort Study). All consecutive SOTr with BJI (01.05.2008–31.12.2019) were included. A nested case–control study to identify risk factors for BJI was performed. Among 4482 patients, 61 SOTr with 82 BJI...

article

Use of statins after liver transplantation is associated with improved survival: results of a nationwide study

Chiara Becchetti, Melisa Dirchwolf, Jonas Schropp, Giulia Magini, more

Alimentary Pharmacology & Therapeutics > 56 > 7 > 1194 - 1204

Background There is limited information on the effects of statins on the outcomes of liver transplantation (LT), regarding either their use by LT recipients or donors. Aim To analyse the association between statin exposure and recipient and graft survival. Methods We included adult LT recipients with deceased donors in a nationwide prospective database study. Using a multistate modelling approach,...

article

Relevance of deceased donor proteinuria for kidney transplantation: A comprehensive national cohort study

Christian Kuhn, Alex Born, Andrea Karolin, Brian Lang, more

Clinical Transplantation > 36 > 4 > n/a - n/a

Purpose Proteinuria is frequent in patients with nephropathies and associated with progressive kidney disease and risk for end stage kidney disease. However, the relevance of deceased donor proteinuria on transplant outcome remains uncertain. In this nationwide cohort study, we evaluated the prevalence of proteinuria in deceased donor candidates and measured the impact on outcome after kidney transplantation...

article

Cancer patient satisfaction with health care professional communication: An international EORTC study

Juan Ignacio Arraras, Johannes Giesinger, Omar Shamieh, Iqbal Bahar, more

Psycho‐Oncology > 31 > 3 > 541 - 547

article

Pre‐transplant donor‐specific HLA antibodies and risk for poor first‐year renal transplant outcomes: results from the Swiss Transplant Cohort Study

Caroline Wehmeier, Patrizia Amico, Daniel Sidler, Urs Wirthmüller, more

Transplant International > 34 > 12 > 2755 - 2768

The aim of this study was to analyze first year renal outcomes in a nationwide prospective multicenter cohort comprising 2215 renal transplants, with a special emphasis on the presence of pre‐transplant donor‐specific HLA antibodies (DSA). All transplants had a complete virtual crossmatch and DSA were detected in 19% (411/2215). The investigated composite endpoint was a poor first‐year outcome defined...

article

Burden, epidemiology, and outcomes of microbiologically confirmed respiratory viral infections in solid organ transplant recipients: a nationwide, multi‐season prospective cohort study

Matteo Mombelli, Brian M. Lang, Dionysios Neofytos, John‐David Aubert, more

American Journal of Transplantation > 21 > 5 > 1789 - 1800

Solid organ transplant (SOT) recipients are exposed to respiratory viral infection (RVI) during seasonal epidemics; however, the associated burden of disease has not been fully characterized. We describe the epidemiology and outcomes of RVI in a cohort enrolling 3294 consecutive patients undergoing SOT from May 2008 to December 2015 in Switzerland. Patient and allograft outcomes, and RVI diagnosed...

article

Pre‐transplant Social Adaptability Index and clinical outcomes in renal transplantation: The Swiss Transplant Cohort study

Kris Denhaerynck, Alexander S. Goldfarb‐Rumyantzev, Gurprataap Sandhu, Sonja Beckmann, more

Clinical Transplantation > 35 > 4 > n/a - n/a

Background The impact of pre‐transplant social determinants of health on post‐transplant outcomes remains understudied. In the United States, poor clinical outcomes are associated with underprivileged status, as assessed by the Social Adaptability Index (SAI), a composite score of education, employment status, marital status, household income, and substance abuse. Using data from the Swiss Transplant...

article

Outcome of kidney transplantation from very senior donors in Switzerland – a national cohort study

Christian Kuhn, Brian M. Lang, Sylvia Lörcher, Andrea Karolin, more

Transplant International > 34 > 4 > 689 - 699

Kidney transplantation from older and marginal donors is effective to confront organ shortage. However, limitations after transplantation of kidneys from very marginal kidney donors remain unclear. We compared patient and graft outcome, achieved allograft function and quality of life of renal transplantations from Very Senior Donors (VSD, defined as donors aged 70 years and older) with Senior Donors...

article

First experience of SARS‐CoV‐2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study

Jonathan Tschopp, Arnaud G. L'Huillier, Matteo Mombelli, Nicolas J. Mueller, more

American Journal of Transplantation > 20 > 10 > 2876 - 2882

Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, comprehensive data of SARS‐CoV‐2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical...

article

Microbiologically documented infections after adult allogeneic hematopoietic cell transplantation: A 5‐year analysis within the Swiss Transplant Cohort study

Diem‐Lan Vu, Julie‐Anne Dayer, Stavroula Masouridi‐Levrat, Christophe Combescure, more

Transplant Infectious Disease > 22 > 4 > n/a - n/a

Background Infections are an important complication after allogeneic hematopoietic cell transplantation (allo‐HCT). The present study aimed at determining the landscape of infections occurring in a large cohort of allo‐HCT patients, as well as associated risk factors for infections and for one‐year non‐relapse mortality. Methods This is a retrospective cohort study using STCS and EBMT databases...

article

Management of allergy transfer upon solid organ transplantation

Yannick D. Muller, Julien Vionnet, Franziska Beyeler, Philippe Eigenmann, more

American Journal of Transplantation > 20 > 3 > 834 - 843

Allergy transfer upon solid organ transplantation has been reported in the literature, although only few data are available as to the frequency, significance, and management of these cases. Based on a review of 577 consecutive deceased donors from the Swisstransplant Donor‐Registry, 3 cases (0.5%) of fatal anaphylaxis were identified, 2 because of peanut and 1 of wasp allergy. The sera of all 3 donors...

article

Reconstruction of chronic scapholunate dissociation with the modified scapholunate axis method (SLAM)

Juergen H. Dolderer, Katja Zimny, Silvan M. Klein, Michael Koller, more

Archives of Orthopaedic and Trauma Surgery > 2019 > 139 > 11 > 1641-1647

Introduction Injury to the scapholunate (SL) ligament represents a common trauma of the wrist but is frequently misdiagnosed because of non-specific pain. Established methods for SL reconstruction mainly focus on reducing pain and maintaining the reposition result at the expense of mobility and strength. This study aimed at restoring stability and reducing pain while simultaneously maintaining mobility...

article

Phototherapy‐induced elevation of serum level of melanoma inhibitory activity

Elisabeth Datz, Florian Zeman, Michael Koller, Rolf‐Markus Szeimies, more

Photodermatology, Photoimmunology & Photomedicine > 35 > 4 > 255 - 260

Background Phototherapy is a frequently used treatment modality for a variety of dermatologic diseases. UV radiation has different effects on the skin, for example increased production and release of cytokines and other proteins, and is involved in the initiation and progression of skin cancer. Objective of this clinical trial was to investigate potential systemic effects of UV phototherapy on cytokine...

article

Real-World Data on the Use of Hypertonic Saline Nasal Spray in ENT Practice

Christoph Bergmann, Karolina Müller, Uta Thieme, Florian Zeman, more

SN Comprehensive Clinical Medicine > 2019 > 1 > 5 > 354-361

Hypertonic saline solutions are in broad medicinal use for treatment of various disorders of nose and paranasal sinuses. This trial aimed at the evaluation of safety and efficacy of a hypertonic saline nasal spray within the scope of routine care in an otorhinolaryngological outpatient setting. One hundred and thirty-six patients were included into this uncontrolled clinical trial and received 2.7%...

article

Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study

Peter W. Schreiber, Heike A. Bischoff‐Ferrari, Katia Boggian, Christian Delden, more

Transplant International > 32 > 1 > 49 - 58

Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency [25‐OH vitamin D (25‐OHD) <50 nmol/l] and no deficiency (25‐OHD ≥50 nmol/l) in incident infections after liver transplantation. In 135 liver transplant recipients, blood samples drawn at time of liver transplantation and...

article

Fractional carbon dioxide laser resurfacing of skin grafts: long‐term results of a prospective, randomized, split‐scar, evaluator‐blinded study

Elisabeth Datz, Carmen Schönberger, Florian Zeman, Michael Koller, more

Lasers in Surgery and Medicine > 50 > 10 > 1010 - 1016

Background Fractional ablative resurfacing is frequently used for treating atrophic and acne scars as well as for the early improvement of scars after surgery. No evidence‐based clinical data on improving the appearance of skin grafts by fractional CO₂‐laser resurfacing have been available so far. Objectives The primary outcome parameter was the adaptation of the skin graft to the surrounding skin...

article

Pneumocystis jirovecii pneumonia in solid organ transplant recipients: a descriptive analysis for the Swiss Transplant Cohort

Dionysios Neofytos, Cedric Hirzel, Elsa Boely, Thanh Lecompte, more

Transplant Infectious Disease > 20 > 6 > n/a - n/a

Background Descriptive data on Pneumocystis jirovecii pneumonia (PJP) in solid organ transplant recipients (SOTr) in the era of routine Pneumocystis‐prophylaxis are lacking. Methods All adult SOTr between 2008 and 2016 were included. PJP was diagnosed based on consensus guidelines. Early‐onset PJP was defined as PJP within the first‐year‐post‐transplant. Results 41/2842 SOTr (1.4%) developed...

article

Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant cohort study

Sabine Kuster, Susanne Stampf, Bernhard Gerber, Veronika Baettig, more

Transplant Infectious Disease > 20 > 6 > n/a - n/a

Contemporary, comprehensive data on epidemiology and outcomes of invasive fungal disease (IFD) including breakthrough IFD among allogeneic hematopoietic stem cell transplantation (HSCT) recipients are scarce. We included 479 allogeneic HSCT recipients with 10 invasive candidiasis (IC) and 31 probable/proven invasive mold disease (IMD) from the Swiss Transplant Cohort Study from 01.2009 to 08.2013...

article

Proteolysis of ToxR is controlled by cysteine‐thiol redox state and bile salts in Vibrio cholerae

Mareike Lembke, Nina Pennetzdorfer, Sarah Tutz, Michael Koller, more

Molecular Microbiology > 110 > 5 > 796 - 810

In Vibrio cholerae, virulence gene expression is regulated by a transmembrane‐localized transcription factor complex designated as ToxRS. ToxR harbours two cysteines in the periplasmic domain that can form inter‐ and intramolecular disulfide bonds. In this study, we investigated the σ^E‐dependent inner membrane proteolysis of ToxR, which occurs via the periplasmic‐localized proteases DegS and DegP...

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INFONA - science communication portal

Search results for: Michael Koller

Early childhood allergy prevention behaviors: Trends in Germany from 2015 to 2020

Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

Use of statins after liver transplantation is associated with improved survival: results of a nationwide study

Relevance of deceased donor proteinuria for kidney transplantation: A comprehensive national cohort study

Cancer patient satisfaction with health care professional communication: An international EORTC study

Pre‐transplant donor‐specific HLA antibodies and risk for poor first‐year renal transplant outcomes: results from the Swiss Transplant Cohort Study

Burden, epidemiology, and outcomes of microbiologically confirmed respiratory viral infections in solid organ transplant recipients: a nationwide, multi‐season prospective cohort study

Pre‐transplant Social Adaptability Index and clinical outcomes in renal transplantation: The Swiss Transplant Cohort study

Outcome of kidney transplantation from very senior donors in Switzerland – a national cohort study

First experience of SARS‐CoV‐2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study

Microbiologically documented infections after adult allogeneic hematopoietic cell transplantation: A 5‐year analysis within the Swiss Transplant Cohort study

Management of allergy transfer upon solid organ transplantation

Reconstruction of chronic scapholunate dissociation with the modified scapholunate axis method (SLAM)

Phototherapy‐induced elevation of serum level of melanoma inhibitory activity

Real-World Data on the Use of Hypertonic Saline Nasal Spray in ENT Practice

Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study

Fractional carbon dioxide laser resurfacing of skin grafts: long‐term results of a prospective, randomized, split‐scar, evaluator‐blinded study

Pneumocystis jirovecii pneumonia in solid organ transplant recipients: a descriptive analysis for the Swiss Transplant Cohort

Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant cohort study

Proteolysis of ToxR is controlled by cysteine‐thiol redox state and bile salts in Vibrio cholerae

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