Search results for: Dieter Bingmann

Items from 1 to 12 out of 12 results

article

Aging is associated with a mild acidification in neocortical human neurons in vitro

Udo Bonnet, Dieter Bingmann, Erwin-Josef Speckmann, Martin Wiemann

Journal of Neural Transmission > 2018 > 125 > 10 > 1495-1501

The intracellular pH (pHi) in the cytosol of mammalian central neurons is tightly regulated and small pHi-fluctuations are deemed to modulate inter-/intracellular signaling, excitability, and synaptic plasticity. The resting pHi of young rodent hippocampal pyramidal neurons is known to decrease alongside aging for about 0.1 pH-units. There is no information about the relationship between age and pHi...

chapter

Brainstem NHE-3 Expression and Control of Breathing

Martin Wiemann, Heidrun Kiwull-Schöne, Stilla Frede, Dieter Bingmann, more

Advances in Experimental Medicine and Biology > Post-Genomic Perspectives in Modeling and Control of Breathing > Mechanisms of Central and Carotid Bodies Chemoreception > 39-44

Intracellular acidification by selective inhibition of the Na⁺/H⁺ exchanger type 3 (NHE-3) has been shown to enhance the bioelectric activity of CO₂/H⁺ sensitive neurons cultured in vitro from the ventrolateral medulla oblongata of newborn rats (Wiemann et al., 1998, 1999; Wiemann and Bingmann, 2001). Recently, we demonstrated NHE-3 immunoreactive neurons in brainstem areas with prevalence for central...

chapter

Stereoskopische Volumenvisualierung digitaler histologischer Konfokalbilddaten

Alexander Roth, Hans-Gerd Lipinski, Martin Wiemann, Dieter Bingmann

Informatik aktuell > Bildverarbeitung für die Medizin 2005 > Registrierung > 370-374

Durch Erweiterungen des Median-Filteralgorithmus und einen neuartigen Bildschärfungsalgorithmus, der unter Verwendung der zwei- und dreidimensionalen Fouriertransformation gezielte Manipulationen im Ortsfrequenzbereich vornimmt, ist es gelungen die Bildqualität von Konfokalbildern vitaler Zellpräpa-rate soweit zu steigern, dass sich hiermit hochwertige Volumenvisualisierungen durchführen lassen. Für...

chapter

Bewegungsanalyse von zeitlich aufgenommenen Zellbilddaten in vitro

Sebastian Magosch, Hans-Gerd Lipinski, Martin Wiemann, Dieter Bingmann

Informatik aktuell > Bildverarbeitung für die Medizin 2005 > Visible Light > 400-404

Es wird eine Methode vorgestellt, mit deren Hilfe es möglich ist, rechnergestützt Bewegungsmuster von lebenden Zellkulturen zu erkennen und auszuwerten. Anhand spezifischer Merkmale können in zeitlichen Bildsequenzen Zellen automatisch erkannt und über die Zeit verfolgt werden. Darüber hinaus werden die dabei entstandenen Bewegungsmuster anhand charakteristischer Parameter erfasst.

chapter

Detektion von Kanten lebender Knochenzellen in vitro

Sebastian Magosch, Hans-Gerd Lipinski, Martin Wiemann, Dieter Bingmann

Informatik aktuell > Bildverarbeitung für die Medizin 2004 > Segmentierung II > 180-183

Es wird eine Methode vorgestellt, mit deren Hilfe es möglich ist, gezielt lebende Zellen in einer Knochenzellkultur anhand ihrer geometrischen Form zu selektieren. Dabei werden die Kanten der Zellen mit Hilfe von Kantendetektoren bestimmt. Die Überwachung der angewendeten Kantenbestimmungs-Methode erfolgt dabei durch die gleichzeitige Darstellung von Originalbildern und überlagerten Kanten.

article

Organic and inorganic calcium antagonists inhibit veratridine-induced epileptiform activity in CA3 neurons of the guinea pig

Mark Christian Link, Martin Wiemann, Dieter Bingmann

Epilepsy Research > 2008 > 78 > 2-3 > 147-154

Veratridine is believed to cause epileptiform discharges via its effects on sodium channels. We addressed the question whether calcium currents, known to contribute to the generation of paroxysmal depolarization shifts (PDS) in most models of epilepsies, also contribute to veratridine-induced epileptiform activity. Therefore, we recorded from CA3 neurons (n=50) of veratridine-treated hippocampal slices...

article

Scalp-recorded contingent negative variation (CNV) increases during experimentally induced sustained ischemic pain in humans

Philipp Stude, Claudia Wischniewski, Peter Thümler, Alfred Lehmenkühler, more

Neuroscience Letters > 2003 > 348 > 1 > 9-12

Contingent negative variations (CNV) after acoustic stimuli (S1) followed by optical ones (S2) were recorded using electroencephalography in 22 healthy students both under control conditions and during ischemic pain to study the effects of sustained pain on CNV. Mean negative CNV-amplitudes and integrated areas below CNV were significantly larger during periods of ischemic pain than under control...

article

Valproate acidifies hippocampal CA3-neurons-a novel mode of action

Udo Bonnet, Dieter Bingmann, Tobias Leniger, Norbert Scherbaum, more

European Neuropsychopharmacology > 2002 > 12 > 4 > 279-285

Various hypotheses try to explain the anticonvulsive and mood stabilizing effects of valproate. Among them, amplification of GABAergic inhibition and reduction of membrane excitability is favored. Here we show that superfusion with 0.1-1 mM valproate induced a moderate intracellular acidification of BCECF-AM-loaded CA3-neurons (hippocampal slices, guinea pig) which was measured as the difference between...

article

Ventrolateral neurons of medullary organotypic cultures: intracellular pH regulation and bioelectric activity

Martin Wiemann, Dieter Bingmann

Respiration Physiology > 2001 > 129 > 1-2 > 57 - 70

The hypothesized role of the intracellular pH (pH _i ) as a proximate stimulus for central chemosensitive neurons is reviewed on the basis of data obtained from organotypic cultures of the medulla oblongata (obex level) of new born rats (OMC). Within OMC a subset of neurons responds to hypercapnia as do neurons in the same (or similar) brain areas in vivo. Maneuvers altering intra- and/or extracellular...

article

Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers - a review

Heinz Grunze, Jens Langosch, Karin Schirrmacher, Dieter Bingmann, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2001 > 25 > 8 > 1555-1570

Antiepileptic drugs that are successful as mood stabilizers, e.g. carbamazepine, valproate and lamotrigine, exhibit a characteristic pattern of action on ion fluxes. As a common target, they all affect Na ⁺ - and Ca ² ⁺ inward and K ⁺ outward currents.Furthermore, they have a variety of interactions with the metabolism and receptor occupation of biogenic amines and excitatory...

article

Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones

Udo Bonnet, Dieter Bingmann, Martin Wiemann

European Neuropsychopharmacology > 2000 > 10 > 2 > 97-103

A growing body of evidence hints at intracellular free protons to be involved in the modulation of electric activity of cortical neurones. In this study we demonstrate that application of the weak acid propionate (2.5-20 mM) transiently lowers intracellular pH (pH _i ) of BCECF-AM loaded CA3-neurones in hippocampal slices. The predictability of this acidification prompted us to use propionate...

article

Selective inhibition of the Na+/H+ exchanger type 3 activates CO2/H+-sensitive medullary neurones

M. Wiemann, Jan-Robert Schwark, U. Bonnet, Hans Willi Jansen, more

Pflügers Archiv - European Journal of Physiology > 1999 > 438 > 3 > 255-262

AbstractHypercapnia as well as lowered intracellular pH (pHi) increase the bioelectric activity of CO2/H+-sensitive neurones (VLNcs) of the ventrolateral medulla oblongata. Here we describe that immunoreactive Na+/H+ exchanger (NHE3) is present in ventrolateral neurones from medullary organotypic cultures (obex level). To test whether VLNcs can be acidified and thereby activated by inhibition of NHE3,...

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