Search results for: Fernando G. Noriega

Items from 1 to 20 out of 37 results

article

How micronutrients influence the physiology of mosquitoes

Crisalejandra Rivera-Pérez, Mark E Clifton, Fernando G Noriega

Current Opinion in Insect Science > 2017 > 23 > C > 112-117

Micronutrients or non-energetic nutrients (NEN) are needed in reduced amounts, but are essential for many mosquito physiological processes that influence biological traits from vector competence to reproductive capacity. The NEN include amino acids (AA), vitamins, salts, metals and sterols. Free AA plays critical roles controlling most physiological processes, from digestion to reproduction. Particularly...

article

Fast, ultra-trace detection of juvenile hormone III from mosquitoes using mass spectrometry

Cesar E. Ramirez, Marcela Nouzova, Paolo Benigni, J. Martin E. Quirke, more

Talanta > 2016 > 159 > C > 371-378

In the present work, a new protocol for fast separation and quantification of JH III from biological samples using liquid chromatography coupled to electrospray tandem mass spectrometry is described. In particular, the proposed protocol improves existing methodologies by combining a limited number of sample preparation steps with fast LC-MS/MS detection, providing lower limits of detection and demonstrated...

article

20-hydroxyecdysone stimulation of juvenile hormone biosynthesis by the mosquito corpora allata

Maria Areiza, Marcela Nouzova, Crisalejandra Rivera-Perez, Fernando G. Noriega

Insect Biochemistry and Molecular Biology > 2015 > 64 > Complete > 100-105

Juvenile hormone III (JH) is synthesized by the corpora allata (CA) and plays a key role in mosquito development and reproduction. JH titer decreases in the last instar larvae allowing pupation and metamorphosis to progress. As the anti-metamorphic role of JH comes to an end, the CA of the late pupa (or pharate adult) becomes again “competent” to synthesize JH, which plays an essential role orchestrating...

article

A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity

Crisalejandra Rivera-Perez, Pratik Nyati, Fernando G. Noriega

Insect Biochemistry and Molecular Biology > 2015 > 64 > Complete > 44-50

Farnesyl diphosphate synthase (FPPS) is a key enzyme in isoprenoid biosynthesis, it catalyzes the head-to-tail condensation of dimethylallyl diphosphate (DMAPP) with two molecules of isopentenyl diphosphate (IPP) to generate farnesyl diphosphate (FPP), a precursor of juvenile hormone (JH). In this study, we functionally characterized an Aedes aegypti FPPS (AaFPPS) expressed in the corpora allata....

article

Allatostatin-C reversibly blocks the transport of citrate out of the mitochondria and inhibits juvenile hormone synthesis in mosquitoes

Marcela Nouzova, Crisalejandra Rivera-Perez, Fernando G. Noriega

Insect Biochemistry and Molecular Biology > 2015 > 57 > Complete > 20-26

Aedes aegypti allatostatin-C (AeaAST-C or PISCF-AST) is a strong and fast reversible inhibitor of juvenile hormone III (JH III) synthesis by the corpora allata (CA) of mosquitoes; however, its mechanism of action remains poorly understood. AeaAST-C showed no inhibitory activity in the presence of any of the intermediate precursors of JH III indicating that the AeaAST-C target is located before the...

article

Coordinated changes in JH biosynthesis and JH hemolymph titers in Aedes aegypti mosquitoes

Salvador Hernández-Martínez, Crisalejandra Rivera-Perez, Marcela Nouzova, Fernando G. Noriega

Journal of Insect Physiology > 2015 > 72 > Complete > 22-27

Juvenile hormone III (JH) is synthesized by the corpora allata (CA) and plays a key role in mosquito development and reproduction. A decrease in JH titer during the last instar larvae allows pupation and metamorphosis to proceed. As the anti-metamorphic role of JH comes to an end, the CA of the late pupa once again synthesizes JH, which plays an essential role in orchestrating reproductive maturation...

article

Ecdysis triggering hormone ensures proper timing of juvenile hormone biosynthesis in pharate adult mosquitoes

Maria Areiza, Marcela Nouzova, Crisalejandra Rivera-Perez, Fernando G. Noriega

Insect Biochemistry and Molecular Biology > 2014 > 54 > Complete > 98-105

Juvenile hormones (JHs) are synthesized by the corpora allata (CA) and play a key role in insect development. A decrease of JH titer in the last instar larvae allows pupation and metamorphosis to proceed. As the anti-metamorphic role of JH comes to an end, the CA of the late pupa (or pharate adult) becomes again “competent” to synthesize JH, which would play an essential role orchestrating reproductive...

article

Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology

Crisalejandra Rivera-Perez, Marcela Nouzova, Ivanna Lamboglia, Fernando G. Noriega

Insect Biochemistry and Molecular Biology > 2014 > 51 > Complete > 1-9

Juvenile hormone (JH) regulates reproductive maturation in insects; therefore interruption of JH biosynthesis has been considered as a strategy for the development of target-specific insecticides. The corpora allata (CA) from mosquitoes is highly specialized to supply variable levels of JH, which are linked to ovarian developmental stages and influenced by nutritional signals. However, very little...

article

Sublethal metal stress response of larvae of Aedes aegypti

Mario H. Perez, Fernando G. Noriega

Physiological Entomology > 39 > 2 > 111 - 119

Aedes aegypti (Diptera: Culicidae) has adapted to urban environments. The urbanization process provides suitable habitats for this disease vector, subsequently increasing the probability of the transmission of pathogens in high‐density environments. Urban environments provide metal‐stressed larval habitats. However, little is known about the physiological cost of metal stress or how this might affect...

article

Male Aedes aegypti mosquitoes use JH III transferred during copulation to influence previtellogenic ovary physiology and affect the reproductive output of female mosquitoes

Mark E. Clifton, Stefano Correa, Crisalejandra Rivera-Perez, Marcela Nouzova, more

Journal of Insect Physiology > 2014 > 64 > Complete > 40-47

The effect of male accessory gland substances on female reproductive physiology has been previously described as “activating” egg development. However, no mechanism has been described that can explain how male mosquitoes are able to influence egg development in female mosquitoes. To investigate how male mosquitoes are able to influence ovarian physiology and reproductive output we explored three main...

article

Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes

Crisalejandra Rivera-Perez, Marcela Nouzova, Mark. E. Clifton, Elena Martin Garcia, more

Insect Biochemistry and Molecular Biology > 2013 > 43 > 8 > 675-682

The juvenile hormones (JHs) play a central role in insect reproduction, development and behavior. Interrupting JH biosynthesis has long been considered a promising strategy for the development of target-specific insecticides. Using a combination of RNAi, in vivo and in vitro studies we characterized the last unknown biosynthetic enzyme of the JH pathway, a fatty aldehyde dehydrogenase (AaALDH3) that...

article

The insulin/TOR signal transduction pathway is involved in the nutritional regulation of juvenile hormone synthesis in Aedes aegypti

Meritxell Pérez-Hedo, Crisalejandra Rivera-Perez, Fernando G. Noriega

Insect Biochemistry and Molecular Biology > 2013 > 43 > 6 > 495-500

Juvenile hormone (JH) levels must be modulated to permit the normal progress of development and reproductive maturation in mosquitoes. JH is part of a transduction system that assesses nutritional information and controls reproduction in mosquitoes. Adult female Aedes aegypti show nutritionally-dependent dynamic changes in corpora allata (CA) JH biosynthetic activities. A coordinated expression of...

article

Aedes aegypti pharate 1st instar quiescence: A case for anticipatory reproductive plasticity

Mario H. Perez, Fernando G. Noriega

Journal of Insect Physiology > 2013 > 59 > 3 > 318-324

Aedes aegypti mosquitoes use pharate 1st instar quiescence to cope with fluctuations in water availability hosting a fully developed 1st instar larvae within the chorion. The duration of this quiescence has been shown to affect larval fitness. This study sought to determine if an extended egg quiescence can elicit a plastic response resulting in an adult phenotype distinct from adults reared from...

article

FUNCTIONAL ANALYSIS OF A MOSQUITO SHORT‐CHAIN DEHYDROGENASE CLUSTER

Jaime G. Mayoral, Kate T. Leonard, Marcela Nouzova, Fernando G. Noriega, more

Archives of Insect Biochemistry and Physiology > 82 > 2 > 96 - 115

The short‐chain dehydrogenases (SDR) constitute one of the oldest and largest families of enzymes with over 46,000 members in sequence databases. About 25% of all known dehydrogenases belong to the SDR family. SDR enzymes have critical roles in lipid, amino acid, carbohydrate, hormone, and xenobiotic metabolism as well as in redox sensor mechanisms. This family is present in archaea, bacteria, and eukaryota, emphasizing their versatility and fundamental importance for metabolic processes. We identified a cluster of eight SDRs in the mosquito Aedes aegypti (AaSDRs). Members of the cluster differ in tissue specificity and developmental expression. Heterologous expression produced recombinant proteins that had diverse substrate specificities, but distinct from the conventional insect alcohol (ethanol) dehydrogenases. They are all NADP...

article

Characterization of an isopentenyl diphosphate isomerase involved in the juvenile hormone pathway in Aedes aegypti

Miguel E. Diaz, Jaime G. Mayoral, Horacio Priestap, Marcela Nouzova, more

Insect Biochemistry and Molecular Biology > 2012 > 42 > 10 > 751-757

Isopentenyl diphosphate isomerase (IPPI) is an enzyme involved in the synthesis of juvenile hormone (JH) in the corpora allata (CA) of insects. IPPI catalyzes the conversion of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP); afterward IPP and DMAPP condense in a head-to-tail manner to produce geranyl diphosphate (GPP), this head-to-tail condensation can be repeated, by the...

article

The fate of follicles after a blood meal is dependent on previtellogenic nutrition and juvenile hormone in Aedes aegypti

Mark E. Clifton, Fernando G. Noriega

Journal of Insect Physiology > 2012 > 58 > 7 > 1007-1019

Juvenile hormone (JH) mediates the relationship between fecundity and nutrition during the gonotrophic cycle of the mosquito in three ways: (1) by regulating initial previtellogenic development, (2) by mediating previtellogenic resorption of follicles and (3) by altering intrinsic previtellogenic follicle “quality”, physiology, and competitiveness thereby predetermining the fate of follicles after...

article

Aedes aegypti pharate 1st instar quiescence affects larval fitness and metal tolerance

Mario H. Perez, Fernando G. Noriega

Journal of Insect Physiology > 2012 > 58 > 6 > 824-829

The eggs of the mosquito Aedes aegypti possess the ability to undergo an extended quiescence hosting a fully developed 1st instar larvae within the chorion. As a result of this life history trait pharate larvae can withstand months of quiescence inside the egg where they depend on stored maternal reserves. A. aegypti mosquitoes are frequently associated with urban habitats that may contain significant...

article

Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes

Marcela Nouzova, Anne Brockhoff, Jaime G. Mayoral, Marianne Goodwin, more

Peptides > 2012 > 34 > 1 > 201-208

Allatotropin is an insect neuropeptide with pleiotropic actions on a variety of different tissues. In the present work we describe the identification, cloning and functional and molecular characterization of an Aedes aegypti allatotropin receptor (AeATr) and provide a detailed quantitative study of the expression of the AeATr gene in the adult mosquito. Analysis of the tissue distribution of AeATr...

article

A coordinated expression of biosynthetic enzymes controls the flux of juvenile hormone precursors in the corpora allata of mosquitoes

Marcela Nouzova, Marten J. Edwards, Jaime G. Mayoral, Fernando G. Noriega

Insect Biochemistry and Molecular Biology > 2011 > 41 > 9 > 660-669

Juvenile hormone (JH) is a key regulator of metamorphosis and ovarian development in mosquitoes. Adult female Aedes aegypti mosquitoes show developmental and dynamically regulated changes of JH synthesis. Newly emerged females have corpora allata (CA) with low biosynthetic activity, but they produce high amounts of JH a day later; blood feeding results in a striking decrease in JH synthesis, but the...

article

Nutrient limitation results in juvenile hormone-mediated resorption of previtellogenic ovarian follicles in mosquitoes

Mark E. Clifton, Fernando G. Noriega

Journal of Insect Physiology > 2011 > 57 > 9 > 1274-1281

Juvenile hormone (JH) is a central hormonal regulator of previtellogenic development in female Aedes aegypti mosquitoes. JH levels are low at eclosion and increase during the first day after adult emergence. This initial rise in JH is essential for female reproductive maturation. After previtellogenic maturation is complete, the mosquito enters a ‘state-of-arrest’ during which JH synthesis continues...

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Search results for: Fernando G. Noriega

How micronutrients influence the physiology of mosquitoes

Fast, ultra-trace detection of juvenile hormone III from mosquitoes using mass spectrometry

20-hydroxyecdysone stimulation of juvenile hormone biosynthesis by the mosquito corpora allata

A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity

Allatostatin-C reversibly blocks the transport of citrate out of the mitochondria and inhibits juvenile hormone synthesis in mosquitoes

Coordinated changes in JH biosynthesis and JH hemolymph titers in Aedes aegypti mosquitoes

Ecdysis triggering hormone ensures proper timing of juvenile hormone biosynthesis in pharate adult mosquitoes

Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology

Sublethal metal stress response of larvae of Aedes aegypti

Male Aedes aegypti mosquitoes use JH III transferred during copulation to influence previtellogenic ovary physiology and affect the reproductive output of female mosquitoes

Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes

The insulin/TOR signal transduction pathway is involved in the nutritional regulation of juvenile hormone synthesis in Aedes aegypti

Aedes aegypti pharate 1st instar quiescence: A case for anticipatory reproductive plasticity

FUNCTIONAL ANALYSIS OF A MOSQUITO SHORT‐CHAIN DEHYDROGENASE CLUSTER

Characterization of an isopentenyl diphosphate isomerase involved in the juvenile hormone pathway in Aedes aegypti

The fate of follicles after a blood meal is dependent on previtellogenic nutrition and juvenile hormone in Aedes aegypti

Aedes aegypti pharate 1st instar quiescence affects larval fitness and metal tolerance

Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes

A coordinated expression of biosynthetic enzymes controls the flux of juvenile hormone precursors in the corpora allata of mosquitoes

Nutrient limitation results in juvenile hormone-mediated resorption of previtellogenic ovarian follicles in mosquitoes

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