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The reaction of the sulfhydryl groups in metallothionein with hydrogen peroxide was examined in HL-60 cells. Partial purification of cell cytosol using Sephadex G-75 chromatography showed that zinc-metallothionein (Zn-MT) was induced by 24-h treatment with 100 μMZnCl2, but the cellular glutathione content and glutathione peroxidase and catalase activities were unaffected. The ratio of H2O2concentrations...
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