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Epitope reactivity of multiple sclerosis (MS) plasma antibodies against the Epstein–Barr virus protein EBNA-1 and its association with HLA DRB1⁎1501 status was investigated in a case-referent study. Based on EBNA-1 fragment reactivity and the effect of peptide blocking, four 29–36 amino acid long EBNA-1 fragments were selected for detailed studies. MS cases had increased antibody reactivity against...
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