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We have solved two families of crystal structures of the human Dicer “platform-PAZ-connector helix” cassette in complex with small interfering RNAs (siRNAs). The structures possess two adjacently positioned pockets: a 2 nt 3′-overhang-binding pocket within the PAZ domain (3′ pocket) and a phosphate-binding pocket within the platform domain (phosphate pocket). One family of complexes contains a knob-like...
Argonaute (Ago) proteins constitute a key component of the RNA-induced silencing complex (RISC). We report the crystal structure of Aquifex aeolicus Ago (Aa-Ago) together with binding and cleavage studies, which establish this eubacterial Ago as a bona fide guide DNA strand-mediated site-specific RNA endonuclease. We have generated a stereochemically robust model of the complex, where the guide DNA-mRNA...
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