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The recent development of ultrafast ultrasound localization microscopy (Errico et al., Nature, 2015) provides new opportunities for imaging the vasculature with sub-diffraction resolution. However, the large number of images to be recorded requires acquisitions lasting several minutes. Therefore, physiological motion far larger than the achievable resolution presents challenges for moving tissues...
Angelman syndrome (AS) is a rare neuro-genetic disorder caused by loss of expression of the maternal copy of UBE3A in the brain inducing severe mental and physical impairments. Due to brain-specific genetic imprinting, the paternal UBE3A is silenced by a long antisense transcript. Inhibition of the antisense transcript could lead to unsilencing of paternal UBE3A, thus providing a therapeutic approach...
In our paper we will report the first step of a new method for changing the diffraction limited point spread function through the utilization of the plasma dispersion effect of silicon coated gold nanoparticles to achieve sub wavelength resolution. The plasma dispersion effect can change the optical coefficients of the silicon, under illumination with a focused laser beam. This laser illumination...
The temporal flickering of contrast agents that labels a biological sample is a unique modality for cellular imaging with single molecule sensitivity. It improves the signal‐to‐noise ratio statistics associated with the noisy in vivo environment and has promising applications in single particle tracking and super‐resolution microscopy techniques. The flickering can be triggered either statistically...
We have developed a technological platform that can be used for remote sensing of nano-vibrations which can be used for biomedical parameters estimation as well as for establishing a directional communication channel. The technology is based upon illuminating a surface with a laser and then using an imaging camera to perform temporal and spatial tracking of secondary speckle patterns in order to have...
Localization of a single fluorescent particle with sub-diffraction limit accuracy is a key merit in fluorescence microscopy. Implementation of nonlinear filtering algorithms prior the localization process can improve the localization accuracy of standard existing methods and also enable the localization of overlapping particles, allowing the use of increased fluorophore activation density, and thereby...
The low-temperature bonding of lithium-niobate to silicon and of indium-phosphide to silicon is reported. The bonding technique is based on modifications to the surfaces of the substrates to-be-bonded, through the deposition of self-assembled, single layers of organic molecules. Chemical functionalization of the monolayers promotes the subsequent formation of bonds across the interface between the...
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