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Retinoic acid and its synthetic derivatives are considered as potential agents in cancer therapy because of its pharmacological effect to promote differentiation and to inhibit proliferation of cancer cells. However, clinical trials are greatly hindered by the side effect of retinoic acid with pharmacological dose and limited knowledge of retinoic acid functionalizing exerted on entire cells. Here,...
Neurodegeneration has been recognized as the main cause for neuronal diseases. Much effort has been paid to investigate the process of neurodegeneration from the viewpoint of molecular biology. However, the mechanisms of some processes are still unclear. Here we use a new means to study neurodegeneration using atomic force microscopy (AFM) from the aspect of cellular integrity. The morphological information...
Physiological conditions of biological samples are regulated by many different parameters including mechanical and biochemical factors etc. Single-cell studies of these parameters are challenging by using conventional bioanalysis methods. However, with the recent advancement in nanotechnology, single-molecule and single-cell analysis is much more accessible. Understanding the changes of neuroblastoma...
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