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Detecting morphological changes in the brain is important for a better understanding of normal aging and brain disorders. Growing and Adaptive MEshes (GAMEs) is a multi-dimensional method for modeling complex brain structures and highlight significant differences between groups, such as healthy subjects versus patients with Alzheimer disease (AD). In this work, we have extended the functionalities...
Multivariate statistics are a powerful tool to analyze morphological changes in three-dimensional brain structures. The Hotelling's T2 (HT2) statistic has previously been used to this purpose. HT2 is a parametric test which assumes normal distribution of the data: when this does not hold, as often happens for shape analysis, the test can still be used as basis for nonparametric permutation tests (PT)...
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