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Background: The collagenases are members of the family of zinc-dependent enzymes known as the matrix metalloproteinases (MMPs). They are the only proteinases that specifically cleave the collagen triple helix, and are important in a large number of physiological and pathological processes. Structures are known for the N-terminal ‘catalytic’ domain of collagenases MMP-1 and MMP-8 and of stromelysin...
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