Search results for: Carlos Sebastian

Items from 1 to 20 out of 21 results

article

Light‐Induced Virtual Electrodes for Microfluidic Droplet Electro‐Coalescence

Riccardo Zamboni, Carlos Sebastián‐Vicente, Cornelia Denz, Jörg Imbrock

Advanced Functional Materials > 34 > 13 > n/a - n/a

Electro‐coalescence is the fusion phenomenon between a pair or more microfluidic droplets that are immersed in an immiscible medium under an electric field. This technique is frequently used to merge confined droplets in surfactant‐stabilized microfluidic emulsions using local electric fields. Despite the necessity of miniaturized electrodes, this method has proven highly successful in microfluidics...

article

Laparoscopic staged colon‐first resection for metastatic colorectal cancer: Perioperative and midterm outcomes from a single‐center experience

Juan Carlos Sebastián‐Tomás, Carlos Domingo‐del Pozo, Segundo Ángel Gómez‐Abril, Sergio Navarro‐Martínez, more

Journal of Surgical Oncology > 122 > 7 > 1453 - 1461

Introduction The present study aimed to evaluate the short‐ and mid‐term outcomes of laparoscopic colon‐first staged resection for colorectal cancer (CRC) and colorectal cancer liver metastases (CRCLM). Methods This study included patients with metastatic CRC who underwent laparoscopic surgical staged resection for the primary tumor and CRCLM between June 2013 and December 2018. Data collection...

article

High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction

María Del Rosario Bauzá, Carlos Sebastián Giménez, Paola Locatelli, Andrea De Lorenzi, more

Drug Delivery and Translational Research > 2019 > 9 > 5 > 935-944

In rodents with acute myocardial infarction (AMI), high mobility group box 1 (HMGB1) injection has produced controversial results. Given the lack of data in large mammals, we searched the dose that would promote angiogenesis and expression of specific regenerative genes in sheep with AMI (protocol 1) and, subsequently, use this dose to study long-term effects on infarct size and left ventricular (LV)...

article

Aligned ovine diaphragmatic myoblasts overexpressing human connexin-43 seeded on poly (l-lactic acid) scaffolds for potential use in cardiac regeneration

Carlos Sebastián Giménez, Paola Locatelli, Florencia Montini Ballarin, Alejandro Orlowski, more

Cytotechnology > 2018 > 70 > 2 > 651-664

Diaphragmatic myoblasts (DMs) are precursors of type-1 muscle cells displaying high exhaustion threshold on account that they contract and relax 20 times/min over a lifespan, making them potentially useful in cardiac regeneration strategies. Besides, it has been shown that biomaterials for stem cell delivery improve cell retention and viability in the target organ. In the present study, we aimed at...

article

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

Rafael M. Ioris, Mirco Galié, Giorgio Ramadori, Jason G. Anderson, more

Cell Reports > 2017 > 18 > 8 > 1858-1868

Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutations that activate phosphatidylinositol-3-kinase (PI3K) signaling, and overexpression of SIRT6 reduces growth, progression, and grade of breast cancer in a mouse...

article

The Various Metabolic Sources of Histone Acetylation

Carlos Sebastián, Raul Mostoslavsky

Trends in Endocrinology & Metabolism > 2017 > 28 > 2 > 85-87

Glucose-derived acetyl-CoA levels directly impact histone acetylation, linking the energetic status of the cell to its epigenome. Two recent reports showed that other carbon sources can contribute to the acetyl-CoA pool used for histone acetylation, highlighting the metabolic plasticity that allows cells to respond to nutrient availability.

article

Sox2 Suppresses Gastric Tumorigenesis in Mice

Abby Sarkar, Aaron J. Huebner, Rita Sulahian, Anthony Anselmo, more

Cell Reports > 2016 > 16 > 7 > 1929-1941

Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach homeostasis and disease. By using ChIP-seq analysis, we have found that the majority of Sox2 targets in gastric epithelial cells are tissue specific and related to functions such as endoderm development, Wnt signaling, and gastric cancer...

article

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

Sita Kugel, Carlos Sebastián, Julien Fitamant, Kenneth N. Ross, more

Cell > 2016 > 165 > 6 > 1401-1415

Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is known about how they control tumorigenesis. Here, we uncover an epigenetic program mediated by the NAD⁺-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppression of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies. SIRT6 inactivation accelerates PDAC progression...

chapter

Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance

Debra Toiber, Carlos Sebastian, Raul Mostoslavsky

Handbook of Experimental Pharmacology > Histone Deacetylases: the Biology and Clinical Implication > 189-224

Sirtuins are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. This group of enzymes relies on nicotinamide adenine dinucleotide (NAD⁺) as a cofactor linking their activity to the cellular metabolic status. Originally found in yeast, Sir2 was discovered as a silencing factor and has been shown to mediate the effects of calorie restriction on lifespan...

article

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

Sita Kugel, Jessica L. Feldman, Mark A. Klein, Dafne M. Silberman, more

Cell Reports > 2015 > 13 > 3 > 479-488

Chromatin factors have emerged as the most frequently dysregulated family of proteins in cancer. We have previously identified the histone deacetylase SIRT6 as a key tumor suppressor, yet whether point mutations are selected for in cancer remains unclear. In this manuscript, we characterized naturally occurring patient-derived SIRT6 mutations. Strikingly, all the mutations significantly affected either...

article

The role of mammalian sirtuins in cancer metabolism

Carlos Sebastián, Raul Mostoslavsky

Seminars in Cell & Developmental Biology > 2015 > 43 > C > 33-42

Metabolic reprogramming has recently emerged as a key feature of cancer cells, which need to rewire their cellular metabolism in order to sustain their faster proliferation and growth. New insight into the molecular mechanisms governing this metabolic reprogramming has implicated mammalian sirtuins as important regulators of cancer metabolism. Sirtuins are NAD⁺-dependent protein deacylases involved...

article

Aorto‐right atrial fistula secondary to rupture of an occluded old saphenous venous graft to right coronary artery

Carlos Sebastian Balestrini, José Federico Saaibi, Santiago Navas Ortiz

Catheterization and Cardiovascular Interventions > 84 > 3 > 513 - 518

We report a case of an acquired aorta–right atrial fistula, secondary to a ruptured proximal anastomosis of an old saphenous vein graft 12 years after a coronary artery bypass surgery, in a 57 year old patient with multiple cardiovascular risk factors. On admission, he presented with congestive heart failure and on examination a continuous murmur was detected on the right parasternal border. Catheterization...

article

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

Selma Masri, Paul Rigor, Marlene Cervantes, Nicholas Ceglia, more

Cell > 2014 > 158 > 3 > 659-672

Circadian rhythms are intimately linked to cellular metabolism. Specifically, the NAD ⁺ -dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to clock function. Whereas SIRT1 exhibits diversity in deacetylation targets and subcellular localization, SIRT6 is the only constitutively chromatin-associated sirtuin and is prominently present at transcriptionally active...

article

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

Debra Toiber, Fabian Erdel, Karim Bouazoune, Dafne M. Silberman, more

Molecular Cell > 2013 > 51 > 4 > 454-468

DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration, and aging. Little is known about the role of chromatin accessibility in DNA repair. Here, we find that the deacetylase sirtuin 6 (SIRT6) is one of the earliest factors recruited to double-strand breaks (DSBs). SIRT6 recruits the chromatin remodeler SNF2H to DSBs and focally deacetylates histone H3K56. Lack of SIRT6...

article

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Carlos Sebastián, Bernadette M.M. Zwaans, Dafne M. Silberman, Melissa Gymrek, more

Cell > 2012 > 151 > 6 > 1185-1199

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells. Importantly, loss of SIRT6 leads to tumor formation without activation of known oncogenes, whereas transformed...

article

SIRT3 in Calorie Restriction: Can You Hear Me Now?

Carlos Sebastian, Raul Mostoslavsky

Cell > 2010 > 143 > 5 > 667-668

Caloric restriction decreases oxidative damage and extends life span in many organisms. Someya et al. (2010) show that the sirtuin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promoting the mitochondrial antioxidant system through the regulation of isocitrate dehydrogenase 2 (Idh2).

article

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Lei Zhong, Agustina D'Urso, Debra Toiber, Carlos Sebastian, more

Cell > 2010 > 140 > 2 > 280-293

SIRT6 is a member of a highly conserved family of NAD ⁺ -dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the...

article

Narrow QRS tachycardia with long R–P

Carlos Sebastian Ribas, Adrian Baranchuk, Stuart J. Connolly, Carlos A. Morillo

International Journal of Cardiology > 2008 > 127 > 2 > e57-e60

Appropriate ECG diagnosis of a narrow complex tachycardia can be sometimes challenging. We present a case of palpitations and an electrocardiogram showing a long RP relationship. The ECG characteristics and the differential diagnosis and mechanisms documented during electrophysiology testing are discussed.

article

Applying physical input–output tables of energy to estimate the energy ecological footprint (EEF) of Galicia (NW Spain)

Adolfo Carballo Penela, Carlos Sebastián Villasante

Energy Policy > 2008 > 36 > 3 > 1148-1163

Nowadays, the achievement of sustainable development constitutes an important constraint in the design of energy policies, being necessary the development of reliable indicators to obtain helpful information about the use of energy resources.The ecological footprint (EF) provides a referential framework for the analysis of human demand for bioproductivity, including energy issues. In this article,...

article

Interpretation of radiotracer experiments in an industrial battery of desanders with simultaneous stochastic and non-stochastic flows

Jean-Pierre Leclerc, Raphael Mesnier, Carlos Sebastian Calvo, Gerardo Maghella, more

Applied Radiation and Isotopes > 2007 > 65 > 11 > 1208-1214

Radiotracer experiments have been conducted in an industrial battery of twelve desanders located at the water treatment plant of Lima. The flow behavior is complex because it includes the superposition of a stochastic flow, which is intrinsic to the process itself, and of a non-stochastic flow induced by local strong currents at the surface. These currents are non-stochastic because they are different...

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INFONA - science communication portal

Search results for: Carlos Sebastian

Light‐Induced Virtual Electrodes for Microfluidic Droplet Electro‐Coalescence

Laparoscopic staged colon‐first resection for metastatic colorectal cancer: Perioperative and midterm outcomes from a single‐center experience

High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction

Aligned ovine diaphragmatic myoblasts overexpressing human connexin-43 seeded on poly (l-lactic acid) scaffolds for potential use in cardiac regeneration

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

The Various Metabolic Sources of Histone Acetylation

Sox2 Suppresses Gastric Tumorigenesis in Mice

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

The role of mammalian sirtuins in cancer metabolism

Aorto‐right atrial fistula secondary to rupture of an occluded old saphenous venous graft to right coronary artery

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

SIRT3 in Calorie Restriction: Can You Hear Me Now?

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Narrow QRS tachycardia with long R–P

Applying physical input–output tables of energy to estimate the energy ecological footprint (EEF) of Galicia (NW Spain)

Interpretation of radiotracer experiments in an industrial battery of desanders with simultaneous stochastic and non-stochastic flows

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