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The pulmonary epithelial lining fluid (ELF) contains substrates, e.g., ascorbic acid (AH 2 ), uric acid (UA), glutathione (GSH), proteins, and unsaturated lipids, which undergo facile reaction with inhaled ozone (O 3 ). Reactions near the ELF gas/liquid interface likely provide the driving force for O 3 absorption (“reactive absorption”) and constrain O 3 diffusion...