Search results for: Cinzia Domenicotti

Items from 1 to 20 out of 36 results

article

Glutathione and the switch of aerobic metabolism collaborate for multi-drug resistance of neuroblastoma

Cinzia Domenicotti, Andrea Speciale, Ombretta Garbarino, Alberto Izzotti, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S69

The availability of antioxidants is recognized as one of the critical factors able to make cancer cells resistant to chemotherapy. In this context, it has been demonstrated that many chemoresistant cancers display high levels of glutathione (GSH) and consequently, its depletion by L-buthionine sulfoximine (BSO), has been proposed as a chemosensitizing therapy. To investigate the role of GSH and of...

article

ATRA-induced neuronal differentiation reduces cell ability to adapt to oxidative stress: role of Nrf2 and HO-1

Sabrina Piras, Anna Lisa Furfaro, Cinzia Domenicotti, Nicola Traverso, more

Free Radical Biology and Medicine > 2016 > 96 > S1 > S49

article

Oxysterol mixture and, in particular, 27‐hydroxycholesterol drive M2 polarization of human macrophages

Barbara Marengo, Francesca Bellora, Roberta Ricciarelli, Chiara De Ciucis, more

BioFactors > 42 > 1 > 80 - 92

Macrophages play a crucial role in atherosclerosis progression. Classically activated M1 macrophages have been found in rupture‐prone atherosclerotic plaques whereas alternatively activated macrophages, M2, localize in stable plaque. Macrophage accumulation of cholesterol and of its oxidized derivatives (oxysterols) leads to the formation of foam cells, a hallmark of atherosclerotic lesions. In this...

article

A PHYSIOLOGICAL ROLE FOR AMYLOID BETA IN CYCLIC AMP-STIMULATED LONG TERM POTENTIATION

Ernesto Fedele, Daniela Puzzo, Olga Bruno, Elisa Canepa, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2014 > 10 > 4 Supplement > P328

article

A novel mechanism for cyclic adenosine monophosphate–mediated memory formation: Role of amyloid beta

Roberta Ricciarelli, Daniela Puzzo, Olga Bruno, Elisa Canepa, more

Annals of Neurology > 75 > 4 > 602 - 607

Cyclic adenosine monophosphate (cAMP) regulates long‐term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aβ levels, and that the modulatory...

article

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Anna Lisa Furfaro, Sabrina Piras, Mario Passalacqua, Cinzia Domenicotti, more

BBA - Molecular Basis of Disease > 2014 > 1842 > 4 > 613-622

High-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance. Considering the involvement of the nuclear factor-erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1) in the antioxidant and detoxifying ability of cancer cells, in this study we have investigated...

article

Short exposure of albumin to high concentrations of malondialdehyde does not mimic physiological conditions

Susanna Millanta, Anna Lisa Furfaro, Paolo Carlier, Bruno Tasso, more

Experimental and Molecular Pathology > 2013 > 94 > 1 > 270-276

Malondialdehyde (MDA), a major lipid peroxidation product, spontaneously binds to, and modifies proteins. In vivo, proteins are physiologically exposed to micromolar MDA concentrations for long periods. In order to mimic this process in vitro, protein modification is often performed by short exposure to millimolar MDA concentrations, also in order to generate antigenic structures for antibody production...

article

Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

Anna Lisa Furfaro, José Raúl Zumba Macay, Barbara Marengo, Mariapaola Nitti, more

Free Radical Biology and Medicine > 2012 > 52 > 2 > 488-496

Cancer cell survival is known to be related to the ability to counteract oxidative stress, and glutathione (GSH) depletion has been proposed as a mechanism to sensitize cells to anticancer therapy. However, we observed that GI-ME-N cells, a neuroblastoma cell line without MYCN amplification, are able to survive even if GSH-depleted by l-buthionine-(S,R)-sulfoximine (BSO). Here, we show that in GI-ME-N...

article

Cholesterol and amyloid-beta: Evidence for a cross-talk between astrocytes and neuronal cells

Elisa Canepa, Roberta Borghi, Jose Viña, Nicola Traverso, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2011 > 7 > 4 Supplement > S382-S383

article

PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation

Mariapaola Nitti, Anna Lisa Furfaro, Claudia Cevasco, Nicola Traverso, more

Cellular Signalling > 2010 > 22 > 5 > 828-835

The role of reactive oxygen species (ROS) in the regulation of signal transduction processes has been well established in many cell types and recently the fine tuning of redox signalling in neurons received increasing attention. With regard to this, the involvement of NADPH oxidase (NOX) in neuronal pathophysiology has been proposed but deserves more investigation. In the present study, we used SH-SY5Y...

article

Processing of the amyloid precursor protein: Role of protein kinase C and myosin IIB

Francesca Argellati, Cinzia Domenicotti, Maria A. Pronzato, Umberto M. Marinari, more

Alzheimer's & Dementia > 2009 > 5 > 4(S) > P493

article

Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma

Barbara Marengo, Chiara De Ciucis, Daniela Verzola, Vito Pistoia, more

Free Radical Biology and Medicine > 2008 > 44 > 3 > 474-482

Glutathione (GSH) depletion is widely used to sensitize cells to anticancer treatment inducing the progression of programmed cell death and overcoming chemoresistance. It has been reported that neuroblastoma cells with MYCN amplification are unable to start TRAIL-dependent death and MYCN, in concert with cytotoxic drugs, efficiently induces the mitochondrial pathway of apoptosis through oxidative...

article

PKC signaling in oxidative hepatic damage

Mariapaola Nitti, Maria A. Pronzato, Umberto M. Marinari, Cinzia Domenicotti

Molecular Aspects of Medicine > 2008 > 29 > 1-2 > 36-42

Protein kinase C (PKC) is a family of isoenzymes differently involved in cell response to injury and many studies describe their role as “stress sensors”. Oxidative stress is strictly involved in the pathogenesis of chronic liver diseases including alcohol- or drug-induced hepatotoxicity, iron overload, hepatitis and hepatocarcinoma development, but molecular mechanisms are not really defined. A crucial...

article

Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-β deposition in N2a cells

Sara Massone, Francesca Argellati, Mario Passalacqua, Andrea Armirotti, more

Biochemical and Biophysical Research Communications > 2007 > 362 > 3 > 633-638

The Alzheimer’s disease (AD) brain pathology is characterized by extracellular deposits of amyloid-β (Aβ) peptides and intraneuronal fibrillar structures. These pathological features may be functionally linked, but the mechanism by which Aβ accumulation relates to neuronal degeneration is still poorly understood. Aβ peptides are fragments cleaved from the amyloid precursor protein (APP), a transmembrane...

article

Vitamin E and neurodegenerative diseases

Roberta Ricciarelli, Francesca Argellati, Maria A. Pronzato, Cinzia Domenicotti

Molecular Aspects of Medicine > 2007 > 28 > 5-6 > 591-606

Vitamin E is essential for neurological function. This fact, together with a growing body of evidence indicating that neurodegenerative processes are associated with oxidative stress, lead to the convincing idea that several neurological disorders may be prevented and/or cured by the antioxidant properties of vitamin E.In this review, some aspects related to the role of vitamin E against Alzheimer’s...

article

PKC delta and NADPH oxidase in AGE-induced neuronal death

Mariapaola Nitti, Anna L. Furfaro, Nicola Traverso, Patrizio Odetti, more

Neuroscience Letters > 2007 > 416 > 3 > 261-265

Advanced glycation end product (AGE) accumulation in brain is believed to contribute to neuronal death in several neurodegenerative diseases. Neurons exposed to AGEs undergo oxidative stress, but the molecular mechanisms able to induce ROS generation and cell death are not yet clear. In this work, we exposed SH-SY5Y neuroblastoma cells to glycated albumin, as a model of AGE-modified protein, and we...

article

Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication

Stefania Patriarca, Anna Lisa Furfaro, Luana Cosso, Elena Pesce Maineri, more

Biogerontology > 2007 > 8 > 3 > 365-372

Heme oxygenase 1 (HO-1) expression is recognized as a marker of cellular response to oxidative stress; since ageing is believed to be related to oxidative “wear and tear”, HO-1 may represent a candidate biomarker of ageing. In our study, the hepatic expression of HO-1 mRNA, evaluated by RT-PCR in 2.5–24 month-old rats, was higher at 6 months than at 2.5 months of age, but thereafter increased no further:...

article

Inactivation of PEMT2 in hepatocytes initiated by DENA in fasted/refed rats

Barbara Marengo, Consuelo Bottini, C.A.M. La Porta, Cinzia Domenicotti, more

Biochemical and Biophysical Research Communications > 2006 > 346 > 1 > 234-241

Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine. We have previously shown that PEMT suppressed hepatoma growth by triggering apoptosis. We investigate whether PEMT controlled cell death and cell proliferation triggered by fasting/refeeding and whether it is a marker of early preneoplastic lesions. The induction...

article

Reactive oxygen species: Biological stimuli of neuroblastoma cell response

Barbara Marengo, Lizzia Raffaghello, Vito Pistoia, Damiano Cottalasso, more

Cancer Letters > 2005 > 228 > 1-2 > 111-116

Reactive oxygen species play a critical role in differentiation, proliferation and apoptosis acting as ‘second messengers’ able to regulate sulphydryl groups in signaling molecules as protein kinase C, a family of isoenzymes involved in many cellular responses and implicated in cell transformation. Neuroblastoma is characterised by the production of oxygen intermediates and l-buthionine-S,R-sulfoximine,...

article

Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress

Stefania Patriarca, Anna Lisa Furfaro, Cinzia Domenicotti, Patrizio Odetti, more

BBA - Molecular Basis of Disease > 2005 > 1741 > 1-2 > 48-54

Rats were rendered diabetic with streptozotocin and supplemented or not with N-acetylcysteine (NAC) and taurine (TAU). The liver was examined for the quantity of glutathione (GSH), both total and oxidised (GSSG), by HPLC assay. Moreover, the liver expression of gamma-glutamyl-cysteine synthetase, cysteine dioxygenase and heme oxygenase 1 was evaluated. Streptozotocin-diabetic rats showed decreased...

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INFONA - science communication portal

Search results for: Cinzia Domenicotti

Glutathione and the switch of aerobic metabolism collaborate for multi-drug resistance of neuroblastoma

ATRA-induced neuronal differentiation reduces cell ability to adapt to oxidative stress: role of Nrf2 and HO-1

Oxysterol mixture and, in particular, 27‐hydroxycholesterol drive M2 polarization of human macrophages

A PHYSIOLOGICAL ROLE FOR AMYLOID BETA IN CYCLIC AMP-STIMULATED LONG TERM POTENTIATION

A novel mechanism for cyclic adenosine monophosphate–mediated memory formation: Role of amyloid beta

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Short exposure of albumin to high concentrations of malondialdehyde does not mimic physiological conditions

Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

Cholesterol and amyloid-beta: Evidence for a cross-talk between astrocytes and neuronal cells

PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation

Processing of the amyloid precursor protein: Role of protein kinase C and myosin IIB

Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma

PKC signaling in oxidative hepatic damage

Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-β deposition in N2a cells

Vitamin E and neurodegenerative diseases

PKC delta and NADPH oxidase in AGE-induced neuronal death

Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication

Inactivation of PEMT2 in hepatocytes initiated by DENA in fasted/refed rats

Reactive oxygen species: Biological stimuli of neuroblastoma cell response

Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress

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