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PLZF is a gene disrupted in patients with t(11;17)-associated APL. PLZF encodes a sequence specific DNA binding transcriptional repressor that PLZF interacts with a transcriptional repression complex that includes co-repressors and histone deacetylases (HDACs). ETO, involved in the (8;21) AML-M2 translocation, associates with the same transcriptional repression complex. Using the yeast-two-hybrid...
The purpose of the present study was to develop a technique to identify, isolate and partially purify these membrane bound compartments for further characterizations of their Ca 2+ transport and storage mechanisms. We 45 Ca 2+ -loaded the agonist-sensitive Ca 2+ stores in rat pancreatic acini. The loading was accomplished by first depleting the stores...
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