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CHOP, a member of the C/EBP family of the transcriptional factor, showed a tumor suppressor activity by binding to TCF and inhibiting the Wnt signaling pathway. In this study, to determine whether genetic alterations of CHOP gene are involved in the development and/or progression of the gastric cancers, we have screened a set of 47 gastric adenoma and 81 sporadic gastric cancers for mutations and...
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