Anna Lisa Furfaro

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HO-1 down-regulation increases the efficacy of BRAFV600E inhibition-based therapy in primary melanoma cells

Anna Lisa Furfaro, Gabriella Pietra, Irene Cossu, Umberto M. Marinari, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S64

Heme oxygenase 1 (HO-1) plays a key role in maintaining cell redox balance. Under stress conditions, HO-1 is up-regulated and generates bilirubin, ferritin and carbon monoxide, with antioxidant, antiapoptotic and anti-inflammatory properties [Jozkowicz et al., 2007]. HO-1 induction favors cancer progression [Furfaro et al., 2016] and its involvement in tumor resistance to therapy [Was et al., 2006]...

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Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

Sabrina Piras, Lorenzo Brondolo, Anna Lisa Furfaro, Mario Passalacqua, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S80

Neuronal adaptation to oxidative stress is crucial to prevent degenerative diseases. The role of the Nrf2/HO-1 system in cell response to hydrogen peroxide (H₂O₂) has been investigated using SH-SY5Y neuroblastoma cells as undifferentiated or after differentiation with all-trans retinoic acid (ATRA). We showed that undifferentiated cells resisted to oxidative stimulus and up-regulated HO-1 which was...

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HO-1 Down-Regulation Increases the Efficacy of BRAFV600E Inhibition-Based Therapy in Primary Melanoma Cells

Anna Lisa Furfaro, Gabriella Pietra, Umberto Maria Marinari, Lorenzo Moretta, more

Free Radical Biology and Medicine > 2016 > 100 > S > S122

The inducible enzyme heme oxygenase 1 (HO-1) plays a crucial role in maintaining redox balance. Under stress conditions, HO-1 is up-regulated leading to the generation of bilirubin, ferritin and carbon monoxide, with antioxidant, antiapoptotic and anti-inflammatory properties [1]. The induction of HO-1 is involved in the gain of resistance to oxidation-based therapies and favors cancer progression...

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Neuroblastoma Cell Response to Oxidative Stress Is Impaired by Retinoic Acid-Induced Differentiation: Role of HO-1

Mariapaola Nitti, Sabrina Piras, Anna Lisa Furfaro, Lorenzo Brondolo, more

Free Radical Biology and Medicine > 2016 > 100 > S > S106-S107

The modulation of redox balance is able to drive different cell functions, from differentiation to proliferation. In a previous work, we showed that all-trans retinoic acid (ATRA) induced differentiation of SH-SY5Y neuroblastoma (NB) cells through the generation of reactive oxygen species (ROS) [Nitti et al Cell Signal 2010]. However, ATRA-differentiated NB cells resulted more sensitive to the further...

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ATRA-induced neuronal differentiation reduces cell ability to adapt to oxidative stress: role of Nrf2 and HO-1

Sabrina Piras, Anna Lisa Furfaro, Cinzia Domenicotti, Nicola Traverso, more

Free Radical Biology and Medicine > 2016 > 96 > S1 > S49

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Heme oxygenase-1-derived bilirubin protects endothelial cells against high glucose-induced damage

Meihua He, Mariapaola Nitti, Sabrina Piras, Anna Lisa Furfaro, more

Free Radical Biology and Medicine > 2015 > 89 > C > 91-98

Hyperglycemia and diabetes are associated with endothelial cell dysfunction arising from enhanced oxidative injury, leading to the progression of diabetic vascular pathologies. The redox-sensitive transcription factor nuclear factor-E2-related factor 2 (Nrf2) is a master regulator of antioxidant genes, such as heme oxygenase-1 (HO-1), involved in cellular defenses against oxidative stress. We have...

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HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Anna Lisa Furfaro, Sabrina Piras, Mario Passalacqua, Cinzia Domenicotti, more

BBA - Molecular Basis of Disease > 2014 > 1842 > 4 > 613-622

High-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance. Considering the involvement of the nuclear factor-erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1) in the antioxidant and detoxifying ability of cancer cells, in this study we have investigated...

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Short exposure of albumin to high concentrations of malondialdehyde does not mimic physiological conditions

Susanna Millanta, Anna Lisa Furfaro, Paolo Carlier, Bruno Tasso, more

Experimental and Molecular Pathology > 2013 > 94 > 1 > 270-276

Malondialdehyde (MDA), a major lipid peroxidation product, spontaneously binds to, and modifies proteins. In vivo, proteins are physiologically exposed to micromolar MDA concentrations for long periods. In order to mimic this process in vitro, protein modification is often performed by short exposure to millimolar MDA concentrations, also in order to generate antigenic structures for antibody production...

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Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

Anna Lisa Furfaro, José Raúl Zumba Macay, Barbara Marengo, Mariapaola Nitti, more

Free Radical Biology and Medicine > 2012 > 52 > 2 > 488-496

Cancer cell survival is known to be related to the ability to counteract oxidative stress, and glutathione (GSH) depletion has been proposed as a mechanism to sensitize cells to anticancer therapy. However, we observed that GI-ME-N cells, a neuroblastoma cell line without MYCN amplification, are able to survive even if GSH-depleted by l-buthionine-(S,R)-sulfoximine (BSO). Here, we show that in GI-ME-N...

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PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation

Mariapaola Nitti, Anna Lisa Furfaro, Claudia Cevasco, Nicola Traverso, more

Cellular Signalling > 2010 > 22 > 5 > 828-835

The role of reactive oxygen species (ROS) in the regulation of signal transduction processes has been well established in many cell types and recently the fine tuning of redox signalling in neurons received increasing attention. With regard to this, the involvement of NADPH oxidase (NOX) in neuronal pathophysiology has been proposed but deserves more investigation. In the present study, we used SH-SY5Y...

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Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication

Stefania Patriarca, Anna Lisa Furfaro, Luana Cosso, Elena Pesce Maineri, more

Biogerontology > 2007 > 8 > 3 > 365-372

Heme oxygenase 1 (HO-1) expression is recognized as a marker of cellular response to oxidative stress; since ageing is believed to be related to oxidative “wear and tear”, HO-1 may represent a candidate biomarker of ageing. In our study, the hepatic expression of HO-1 mRNA, evaluated by RT-PCR in 2.5–24 month-old rats, was higher at 6 months than at 2.5 months of age, but thereafter increased no further:...

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Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress

Stefania Patriarca, Anna Lisa Furfaro, Cinzia Domenicotti, Patrizio Odetti, more

BBA - Molecular Basis of Disease > 2005 > 1741 > 1-2 > 48-54

Rats were rendered diabetic with streptozotocin and supplemented or not with N-acetylcysteine (NAC) and taurine (TAU). The liver was examined for the quantity of glutathione (GSH), both total and oxidised (GSSG), by HPLC assay. Moreover, the liver expression of gamma-glutamyl-cysteine synthetase, cysteine dioxygenase and heme oxygenase 1 was evaluated. Streptozotocin-diabetic rats showed decreased...

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Anti malondialdehyde-adduct immunological response as a possible marker of successful aging

Nicola Traverso, Stefania Patriarca, Emanuela Balbis, Anna Lisa Furfaro, more

Experimental Gerontology > 2003 > 38 > 10 > 1129-1135

Contrasting results have been obtained by various researchers about oxidative markers of aging. In this study, a healthy over-90-year-old population was examined for various plasma oxidative biomarkers and compared with a healthy population of blood donors (age range 23-66). Plasma malondialdehyde (MDA), evaluated by means of the thiobarbituric acid test, was significantly higher in the over-90-year-old...

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Search results for: Anna Lisa Furfaro

HO-1 down-regulation increases the efficacy of BRAFV600E inhibition-based therapy in primary melanoma cells

Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

HO-1 Down-Regulation Increases the Efficacy of BRAFV600E Inhibition-Based Therapy in Primary Melanoma Cells

Neuroblastoma Cell Response to Oxidative Stress Is Impaired by Retinoic Acid-Induced Differentiation: Role of HO-1

ATRA-induced neuronal differentiation reduces cell ability to adapt to oxidative stress: role of Nrf2 and HO-1

Heme oxygenase-1-derived bilirubin protects endothelial cells against high glucose-induced damage

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Short exposure of albumin to high concentrations of malondialdehyde does not mimic physiological conditions

Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation

Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication

Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress

Anti malondialdehyde-adduct immunological response as a possible marker of successful aging

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