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Background: A recent genome-wide study (GWAS) has identified GPC5 as a promising susceptibility gene for Lung cancer in never smokers (LCINS). However, the most significant single nucleotide polymorphism (SNP) in this GWAS, rs2352028, has yielded controversial results. The aim of this study was to clarify the relationship between rs2352028 and LCINS. Considering that rs2352028 might be largely marker-SNP...
Polymorphisms in DNA repair and apoptotic pathways may cause variations in chemosensitivity of non‐small‐cell lung cancer (NSCLC) through complex gene–gene and gene–environment interactions. A total of 200 advanced NSCLC patients who received platinum‐based chemotherapies were recruited. The short‐term clinical outcomes were classified as chemosensitive group, including complete remission (CR) and...
BACKGROUND:Matrix metalloproteinase‐1 (MMP‐1), an interstitial collagenase, plays an important role in the breakdown of extracellular matrix and mediates pathways of apoptosis, angiogenesis, and immunity. It has been demonstrated that the overexpression of this enzyme is associated with tumor initiation, invasion, and metastasis. The −1607 single guanine (1G)‐to‐2G polymorphism (reference single nucleotide...
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