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Objective: To evaluate the pharmacodynamic effects of a novel intrauterine drug delivery system, FibroPlant-levonorgestrel (LNG), on the endometrium in 24 postmenopausal women using estrogen substitution therapy (EST) to suppress climacteric symptoms. Design: A 3-year non-comparative prospective clinical trial. Subjects: The treatment with the FibroPlant-LNG intrauterine system (IUS), releasing 14μg...