Search results for: Paulina Koczurkiewicz

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Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug—Minireview of in vitro studies

Paulina Koczurkiewicz, Katarzyna Klaś, Karolina Grabowska, Kamil Piska, more

Phytotherapy Research > 33 > 9 > 2141 - 2151

Triterpene saponins (saponosides) are found in higher plants and display a wide range of biological and pharmacological activities. The antitumor effects of saponins have been proved by their cytotoxic, cytostatic, proapoptotic, and anti‐invasive effects in many cellular models. Saponins hold great potential for being developed into chemopreventive and chemotherapeutic drugs. A promising way of reducing...

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Photostability of Terbinafine Under UVA Irradiation: The Effect of UV Absorbers

Agata Kryczyk‐Poprawa, Paweł Żmudzki, Paulina Koczurkiewicz, Elżbieta Pękala, more

Photochemistry and Photobiology > 95 > 4 > 911 - 923

The photostability of drugs administered topically on unprotected skin is a complex phenomenon that could be connected with the loss of activity or, rather rarely, the occurrence of toxic degradation products. In this study, an in‐depth investigation of the photostability of terbinafine, in both solutions and formulations, was conducted, taking into account the presence of UV absorbers such as TiO...

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Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities

Agnieszka Zagórska, Anna Partyka, Adam Bucki, Marcin Kołaczkowski, more

Chemical Biology & Drug Design > 93 > 4 > 511 - 521

A series of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione has been synthesized in an attempt to discover a new class of psychotropic agents. Compounds were evaluated for their in vitro affinity for serotonin 5‐HT_1A, 5‐HT₇, and phosphodiesterases PDE4 and PDE10. The most potent compound 2‐pyrimidinyl‐1‐piperazinyl‐butyl‐imidazo[2,1‐f]purine‐2,4‐dione (4b) behaved...

article

Correction to: Fibroblast-to-myofibroblast transition in bronchial asthma

Marta Michalik, Katarzyna Wójcik-Pszczoła, Milena Paw, Dawid Wnuk, more

Cellular and Molecular Life Sciences > 2019 > 76 > 1 > 209-209

In the original publication, funding information was inadvertently omitted.

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Fibroblast-to-myofibroblast transition in bronchial asthma

Marta Michalik, Katarzyna Wójcik-Pszczoła, Milena Paw, Dawid Wnuk, more

Cellular and Molecular Life Sciences > 2018 > 75 > 21 > 3943-3961

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling plays a significant role. This phenomenon is related to enhanced proliferation of airway smooth muscle cells, elevated extracellular matrix protein secretion and an increased number of myofibroblasts. Phenotypic fibroblast-to-myofibroblast transition represents one of the primary mechanisms by which myofibroblasts...

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Piperlongumine (piplartine) as a lead compound for anticancer agents – Synthesis and properties of analogues: A mini-review

Kamil Piska, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz, Katarzyna Wójcik-Pszczoła, more

European Journal of Medicinal Chemistry > 2018 > 156 > C > 13-20

Piperlongumine, also known as piplartine, is an amide alkaloid of Piper longum L. (long piper), a medical plant known from Ayurvedic medicine. Although was discovered well over fifty years ago, its pharmacological properties have been uncovered in the past decade. In particular, piperlongumine has been most extensively studied as a potential anticancer agent. Piperlongumine has exhibited cytotoxicity...

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The impact of ZnO and TiO2 on the stability of clotrimazole under UVA irradiation: Identification of photocatalytic degradation products and in vitro cytotoxicity assessment

Agata Kryczyk, Paweł Żmudzki, Paulina Koczurkiewicz, Joanna Piotrowska, more

Journal of Pharmaceutical and Biomedical Analysis > 2017 > 145 > C > 283-292

In order to ensure the safe and effective use of pharmaceutical products especially for topical administration photostability testing is necessary. The current paper presents an in-depth analysis of the stability of one of the most common antifungal agents, namely clotrimazole. Clotrimazole has proven to be stable under UVA irradiation in applied experimental conditions, but the presence of catalysts...

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Usnic acid and atranorin exert selective cytostatic and anti-invasive effects on human prostate and melanoma cancer cells

Agnieszka Galanty, Paulina Koczurkiewicz, Dawid Wnuk, Milena Paw, more

Toxicology in Vitro > 2017 > 40 > C > 161-169

Lichens are an interesting source of potential anti-tumor compounds, among which usnic acid and atranorin seem to be the most promising, but their impact on invasive potential of tumor cells has not yet been comprehensively addressed. The aim of the study was focused on the impact of the two lichen metabolites, on the viability (by Trypan blue test and fluoresceine diacetate and ethidium bromide assay),...

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Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents

Kamil Piska, Paulina Koczurkiewicz, Adam Bucki, Katarzyna Wójcik-Pszczoła, more

Investigational New Drugs > 2017 > 35 > 3 > 375-385

Summary Anthracycline antibiotics (ANT), such as doxorubicin or daunorubicin, are a class of anticancer drugs that are widely used in oncology. Although highly effective in cancer therapy, their usefulness is greatly limited by their cardiotoxicity. Possible mechanisms of ANT cardiotoxicity include their conversion to secondary alcohol metabolites (i.e. doxorubicinol, daunorubicinol) catalyzed by...

article

Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy

Anna Rapacz, Krzysztof Kamiński, Jolanta Obniska, Paulina Koczurkiewicz, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2017 > 390 > 6 > 567-579

The purpose of the present study was to examine the analgesic activity of six novel hybrid molecules, which demonstrated in the previous research anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure (scPTZ) tests in mice. The antinociceptive properties were estimated in three models of pain in mice—the hot plate test, the formalin test, and...

article

Two new triterpenoid saponins from the leaves of Impatiens parviflora DC. and their cytotoxic activity

Karolina Grabowska, Irma Podolak, Agnieszka Galanty, Paweł Żmudzki, more

Industrial Crops and Products > 2017 > 96 > C > 71-79

Two new triterpene saponins, camelliagenin A derivatives, were isolated from the leaves of Impatiens parviflora DC. (Balsaminaceae). Their structures were determined based on a combination of one- and two-dimensional nuclear magnetic resonance (NMR) techniques, and mass spectrometry, as 3-O-{[β-d-glucopyranosyl-(1→3)-]-[β-d-glucopyranosyl-(1→2)]}- β-d-glucuronopyranoside 16-O-acetyl-3β,22α,28-trihydroxy-olean-12-ene...

article

Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols

Agnieszka Gunia-Krzyżak, Ewa Żesławska, Karolina Słoczyńska, Paulina Koczurkiewicz, more

European Journal of Medicinal Chemistry > 2016 > 107 > Complete > 26-37

Adequate control of seizures remains an unmet need in epilepsy. In order to identify new anticonvulsant agents, a series of N-trans-cinnamoyl derivatives of selected aminoalkanols was synthetized. The compounds were obtained in the reaction of N-acylation carried out in a two-phase system. The substances were tested in animal models of seizures induced either electrically (maximal electroshock – MES;...

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Growth and motility of human skin fibroblasts on multilayer strong polyelectrolyte films

Magdalena Wytrwal, Paulina Koczurkiewicz, Karol Zrubek, Wiktor Niemiec, more

Journal of Colloid and Interface Science > 2016 > 461 > C > 305-316

Polyelectrolyte multilayers (PEMs) have found application in modifying material surfaces to make them adhesive or non-adhesive for animal cells. However, PEMs made of strong polyelectrolytes are not fully recognized in the literature. This study focuses on the interplay between the properties of PEM assembled from strong polyelectrolytes and cell adhesion and motility. Strong polycations (with quaternary...

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Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition

Katarzyna Wójcik-Pszczoła, Kinga Hińcza, Dawid Wnuk, Dominika Kądziołka, more

Acta Biochimica Polonica > 2016 > 63 > 3 > 437-442

Bronchial asthma is characterized by persistent airway inflammation and airway wall remodeling. Among many different cells and growth factors triggering changes in bronchi structure, transforming growth factor β1-induced fibroblast to myofibroblast transition is believed to be very important. The aim of this study was to evaluate whether theophylline (used in asthma therapy) and two other methylxanthines...

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Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies

Paulina Koczurkiewicz, Jarosław Czyż, Irma Podolak, Katarzyna Wójcik, more

Acta Biochimica Polonica > 2015 > 62 > 3 > 383-393

Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations...

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Synthesis of strong polycations with improved biological properties

Magdalena Wytrwal, Paulina Koczurkiewicz, Kinga Wójcik, Marta Michalik, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 102 > 3 > 721 - 731

Poly(allylamine hydrochloride) (PAH) has found many applications both in biotechnology and biomedical fields. However, its high toxicity toward various mammalian cells significantly limits its effective usage. This study focuses on improving the biological properties of PAH by its modification to strong polyelectrolytes. The strong polycations were prepared by the direct quaternization of PAH amino...

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Triterpene saponosides from Lysimachia ciliata differentially attenuate invasive potential of prostate cancer cells

Paulina Koczurkiewicz, Irma Podolak, Joanna Skrzeczyńska-Moncznik, Michał Sarna, more

Chemico-Biological Interactions > 2013 > 206 > 1 > 6-17

Neither androgen ablation nor chemotherapeutic agents are effective in reducing the risk of prostate cancer progression. On the other hand, multifaceted effects of phytochemicals, such as triterpene saponins, on cancer cells have been suggested. A promising safety and tolerability profile indicate their possible application in the treatment of advanced prostate cancers. We analyzed the specificity,...

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A new cytotoxic triterpene saponin from Lysimachia nummularia L.

Irma Podolak, Paulina Koczurkiewicz, Marta Michalik, Agnieszka Galanty, more

Carbohydrate Research > 2013 > 375 > Complete > 16-20

A new glycosylated triterpene 1 (named nummularoside) was isolated from the underground parts of Lysimachia nummularia L. Its chemical structure was elucidated as 3-O-β-{{[β-d-xylopyranosyl-(1→2)]-[β-d-xylopyranosyl-(1→4)]-β-d-glucopyranosyl-(1→4)}-[β-d-glucopyranosyl-(1→2)-]-α-l-arabinopyranosyl]}, protoprimulagenin A on the basis of extensive NMR and MS spectral data. The saponin showed significant...

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Cytotoxic triterpene saponins from the underground parts of six Lysimachia L. species

Irma Podolak, Paulina Koczurkiewicz, Agnieszka Galanty, Marta Michalik

Biochemical Systematics and Ecology > 2013 > 47 > Complete > 116-120

► Saponins from underground parts of six Lysimachia L. species were investigated. ► Four isolated compounds were reported in genus Lysimachia for the first time. ► Saponins with 13β,28-epoxy-bridge could be a chemotaxonomic marker of Lysimachia. ► Antiproliferative activity against cancer and normal cell lines is discussed.

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Lclet 4 enhances pro-apoptotic and anti-invasive effects of mitoxantrone on human prostate cancer cells - in vitro study

Paulina Koczurkiewicz, Irma Podolak, Katarzyna Wójcik, Agnieszka Galanty, more

Acta Biochimica Polonica > 2013 > 60 > 3 > 331-338

Triterpene saponosides are widely distributed plant secondary metabolites characterized by relatively low systemic cytotoxicity and a range of biological activities. These include anti-inflammatory, antimicrobial, vasoprotective and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs opened perspectives for their application in combined...

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Keywords

APOPTOSIS (3)
CELL MOTILITY (3)
CYTOTOXICITY (3)
TRITERPENE SAPONINS (3)
POLY(ALLYLAMINE HYDROCHLORIDE) (2)
PROLIFERATION (2)
ACTIN CYTOSKELETON (1)
ANTHRACYCLINES (1)
ANTIBACTERIAL POLYMERS (1)
ANTICANCER AGENTS (1)
ANTICONVULSANT ACTIVITY (1)
ANTIDEPRESSANTS (1)
ANXIOLYTICS (1)
ASTHMA (1)
ATOMIC FORCE MICROSCOPY (AFM) (1)
ATRANORIN (1)
AYURVEDA (1)
BINDING STUDIES (1)
BUSPIRONE (1)
CAMELLIAGENIN A (1)
CANCER CELLS (1)
CARDIOTOXICITY (1)
CELL ELASTICITY (1)
CHEMOTHERAPEUTICS (1)
CHEMOTHERAPY (1)
CINNAMAMIDE (1)
CLOTRIMAZOLE (1)
COMBINED THERAPY (1)
CONTACT ANGLE (1)
CRYSTAL STRUCTURE (1)
CYTOTOXIC (1)
CYTOTOXIC ACTIVITY (1)
DRUG METABOLISM (1)
FIBROBLAST-TO-MYOFIBROBLAST TRANSITION (1)
FIBROSIS (1)
FORMALIN (1)
HEPATOTOXICITY (1)
HOT PLATE (1)
HUMAN SKIN FIBROBLASTS (1)
HYBRID COMPOUNDS (1)
IMPATIENS PARVIFLORA (1)
INORGANIC UV FILTERS (1)
INVASIVENESS (1)
LAYER-BY-LAYER (LBL) (1)
LISOFYLLINE (1)
LUNGS (1)
LYSIMACHIA NUMMULARIA (1)
LYSIMACHIA SP. (1)
MECHANICAL FORCES (1)
METASTASIS (1)
MUTAGENIC ACTIVITY (1)
MUTAGENICITY (1)
MYRSINACEAE (1)
NATURAL PRODUCT COMPOUNDS (1)
OXALIPLATIN (1)
PDE INHIBITORS (1)
PENTOXIFYLLINE (1)
PHARMACOKINETICS (1)
PHOTOCATALYTIC DEGRADATION STUDIES (1)
PIPERLONGUMINE (1)
PIPLARTINE (1)
POLYELECTROLYTE MULTILAYER (PEM) (1)
POLYELECTROLYTES (1)
PRO-FIBROTIC AGENTS (1)
PROSTATE CANCER (1)
PSYCHOMOTOR SEIZURES (1)
RESISTANCE (1)
SAR (1)
SEROTONIN RECEPTORS LIGANDS (1)
STRONG POLYELECTROLYTE (1)
TGF-Β-SIGNALLING (1)
THEOPHYLLINE (1)
TRANSFORMING GROWTH FACTOR TYPE Β (1)
TRITERPENE SAPONIN (1)
TRITERPENE SAPONOSIDES (1)
TRITERPENE SAPONOSIDES (LCLET 4); MITOXANTRONE; COMBINED THERAPY; PROSTATE CANCER; APOPTOSIS; INVASIVENESS. (1)
TRITERPENOID SAPONINS (1)
UPLC–MS/MS (1)
USNIC ACID (1)
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Data set

Elsevier (9)
Springer (4)
Wiley (4)
PSJD (3)

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Search results for: Paulina Koczurkiewicz

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