Search results for: Agnieszka Gomułkiewicz

Items from 1 to 10 out of 10 results

article

Nogo‐B expression, in arterial intima, is impeded in the early stages of atherosclerosis in humans

Katarzyna Drożdż, Irmina Grzegorek, Magdalena Chmielewska, Agnieszka Gomułkiewicz, more

APMIS > 122 > 9 > 742 - 749

Nogo‐B (Reticulon 4B) is considered to be a novel vascular marker, which may have a protective role in injury‐induced neointima formation and atherosclerosis. Nogo A/B is found to be crucial for monocyte/macrophage recruitment in acute inflammation and it is expressed in CD68 + macrophages. We hypothesize that macrophage infiltration in atherosclerosis is not dependent on Nogo‐B expression in arterial...

article

Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients

Bozena Werynska, Bartosz Pula, Beata Muszczynska-Bernhard, Agnieszka Gomulkiewicz, more

Experimental and Molecular Pathology > 2013 > 94 > 1 > 301-308

Metallothioneins (MT) are intracellular, low molecular weight proteins (6–7kDa) involved in binding of metal ions, scavenging of free radicals, cell proliferation and apoptosis and resistance to certain chemotherapeutics. Four basic families of MT proteins are distinguished: MT-I, MT-II, MT-III, MT-IV, within each of them different isoforms occur. The study aimed at examining the expression level...

article

Impact of SOX18 expression in cancer cells and vessels on the outcome of invasive ductal breast carcinoma

Bartosz Pula, Mateusz Olbromski, Andrzej Wojnar, Agnieszka Gomulkiewicz, more

Cellular Oncology > 2013 > 36 > 6 > 469-483

Purpose SOX18 is a transcription factor known to be involved in hair follicle, blood and lymphatic vessel development, as well as wound healing processes (together with SOX7 and SOX17). In addition, it has been reported that SOX18 may affect the growth of cancer cells in vitro. Until now, the exact role of SOX18 expression in invasive ductal breast carcinoma (IDC) has remained unknown. Methods In...

article

Corrigendum to “Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber–CA3 pathway” [Molecular and Cellular Neuroscience 50/2 (2012) 147–159]

Grzegorz Wiera, Tomasz Wójtowicz, Katarzyna Lebida, Aleksandra Piotrowska, more

Molecular and Cellular Neuroscience > 2013 > 52 > Complete > 181-182

article

Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber — CA3 pathway

Grzegorz Wiera, Tomasz Wójtowicz, Katarzyna Lebida, Aleksandra Piotrowska, more

Molecular and Cellular Neuroscience > 2012 > 50 > 2 > 147-159

Matrix Metalloproteinases (MMPs) are a family of endopeptidases known to process extracellular proteins. In the last decade, studies carried out mainly on the Schaffer collateral — CA1 hippocampal projection have provided solid evidence that MMPs regulate synaptic plasticity and learning. Recently, our group has shown that MMP blockade disrupts LTP maintenance also in the mossy fiber-CA3 (mf-CA3)...

article

Podoplanin expression by cancer‐associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma

Bartosz Pula, Aleksandra Jethon, Aleksandra Piotrowska, Agnieszka Gomulkiewicz, more

Histopathology > 59 > 6 > 1249 - 1260

Pula B, Jethon A, Piotrowska A, Gomulkiewicz A, Owczarek T, Calik J, Wojnar A, Witkiewicz W, Rys J, Ugorski M, Dziegiel P & Podhorska‐Okolow M  (2011) Histopathology 59, 1249–1260  Podoplanin expression by cancer‐associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma Aims: It has recently been shown that podoplanin, a mucin‐type glycoprotein, is expressed by cancer cells...

article

Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures

Jan Magdalan, Aleksandra Piotrowska, Agnieszka GomuŁkiewicz, Tomasz Sozański, more

Experimental and Toxicologic Pathology > 2011 > 63 > 4 > 311-315

High mortality rate in Amanita phalloides (death cap) intoxications is a result of the acute liver failure following hepatocyte damage due to hepatocellular uptake of amatoxins. α-Amanitin (α-AMA), the major amatoxin, blocks a RNA polymerase II, which results in inhibition of transcription of DNA and protein synthesis processes and leads to hepatocyte death. α-AMA is also a strong apoptosis inductor...

article

Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Experimental and Toxicologic Pathology > 2010 > 62 > 4 > 367-373

Fatalities due to mushroom poisonings are increasing worldwide, with high mortality rate resulting from ingestion of amanitin-producing species. Intoxications caused by amanitin-containing mushrooms represent an unresolved problem in clinical toxicology since no specific and fully efficient antidote is available. The objective of this study was a comparative evaluation of benzylpenicillin (BPCN),...

article

Comparative antidotal efficacy of benzylpenicillin, ceftazidime and rifamycin in cultured human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Archives of Toxicology > 2009 > 83 > 12 > 1091-1096

The most often used antidote to treat poisoning caused by amanitin-containing mushrooms is benzylpenicillin (BPCN). However, a very few reports suggest that other antibiotics such as ceftazidime (CEFT) and rifamycin SV (RIFSV) show better antidote activity against amanitins than BPCN. Given this, there is an ongoing debate as which of three antidotes is optimal for treatment of such poisonings. In...

article

Effects of adaptive exercise on apoptosis in cells of rat renal tubuli

Marzena Podhorska-Okolow, Piotr Dziegiel, Eugenia Murawska-Cialowicz, Jolanta Saczko, more

European Journal of Applied Physiology > 2007 > 99 > 3 > 217-226

Regular exercise is known to improve physiological and functional capacity of many organs due to adaptive processes. We have previously shown that acute exercise in untrained rats results in apoptosis of renal tubular cells and that the apoptotic process seems to be associated with stimulation of angiotensin II, AT1 and AT2 receptors. In this study, we examined the influence of regular training on...

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Search results for: Agnieszka Gomułkiewicz

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