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Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and gp130. Here, we show that IL-11 signaling via IL-11R1/2:gp130 complexes occurs on both the apical and basolateral sides of polarized cells, whereas...
The heterodimeric cytokine Interleukin 23 (IL-23), which consists of the unique subunit p19 and the shared subunit p40, is important for the differentiation and maintenance of TH17 cells. TH17 cells produce the pro-inflammatory cytokine IL-17 and mediate the clearance of pathogens during infections. IL-23 plays a crucial role in autoimmune diseases and tumor development. IL-23 signalling occurs via...
Interleukin (IL-)23 is a central cytokine controlling TH17 development. Overshooting IL-23 signaling contribute to autoimmune diseases. Moreover, GWAS studies have identified several SNPs within the IL-23 receptor, which are associated with autoimmune diseases. IL-23 is a member of the IL-12-type cytokine family and consists of IL-23p19 and p40. Within the IL-12 family, IL-12 and IL-23 share the p40...
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