Search results for: Mario Passalacqua

Items from 1 to 20 out of 36 results

article

Toxicity and inflammatory potential of mineral fibres: The contribute of released soluble metals versus cell contact direct effects

Vanessa Almonti, Stefania Vernazza, Serena Mirata, Sara Tirendi, more

Journal of Applied Toxicology > 44 > 8 > 1166 - 1183

Asbestos fibres have been considered an environmental hazard for decades. However, little is known about the attempts of circulating immune cells to counteract their toxicity. We addressed the early effects of fibre‐released soluble factors (i.e. heavy metals) in naïve immune cells, circulating immediately below the alveolar/endothelial cell layer. By comparison, the direct fibre effects on endotheliocytes...

article

Near‐infrared laser photons induce glutamate release from cerebrocortical nerve terminals

Andrea Amaroli, Manuela Marcoli, Arianna Venturini, Mario Passalacqua, more

Journal of Biophotonics > 11 > 11 > n/a - n/a

Although photons have been repeatedly shown to affect the functioning of the nervous system, their effects on neurotransmitter release have never been investigated. We exploited in vitro models that allow effects involving neuron‐astrocyte network functioning to be detected (mouse cerebrocortical slices) and dissected these effects at cerebrocortical nerve endings and astrocyte processes. Infrared...

article

Homocysteine and A2A-D2 Receptor-Receptor Interaction at Striatal Astrocyte Processes

Chiara Cervetto, Arianna Venturini, Diego Guidolin, Guido Maura, more

Journal of Molecular Neuroscience > 2018 > 65 > 4 > 456-466

The interaction between adenosine A2A and dopamine D2 receptors in striatal neurons is a well-established phenomenon and has opened up new perspectives on the molecular mechanisms involved in Parkinson’s disease. However, it has barely been investigated in astrocytes. Here, we show by immunofluorescence that both A2A and D2 receptors are expressed in adult rat striatal astrocytes in situ, and investigate...

article

Presynaptic GLP‐1 receptors enhance the depolarization‐evoked release of glutamate and GABA in the mouse cortex and hippocampus

Claudia Rebosio, Matilde Balbi, Mario Passalacqua, Roberta Ricciarelli, more

BioFactors > 44 > 2 > 148 - 157

Glucagon‐like peptide‐1 receptors (GLP‐1Rs) have been shown to mediate cognitive‐enhancing and neuroprotective effects in the central nervous system. However, little is known about their physiological roles on central neurotransmission, especially at the presynaptic level. Using purified synaptosomal preparations and immunofluorescence techniques, here we show for the first time that GLP‐1Rs are localized...

article

Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells

Elisa Calcagno, Francesca Caudano, Mario Passalacqua, Maria A. Pronzato, more

Mechanisms of Ageing and Development > 2017 > 166 > C > 1-5

Long-term potentiation (LTP) and the process of memory formation require activation of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) pathways. Notably, recent evidence indicated that both cyclic nucleotides boost the production of amyloid-beta (Aβ) peptides. In particular, cAMP was shown to favor hippocampal LTP by stimulating the synthesis of the amyloid precursor...

article

Glutathione and the switch of aerobic metabolism collaborate for multi-drug resistance of neuroblastoma

Cinzia Domenicotti, Andrea Speciale, Ombretta Garbarino, Alberto Izzotti, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S69

The availability of antioxidants is recognized as one of the critical factors able to make cancer cells resistant to chemotherapy. In this context, it has been demonstrated that many chemoresistant cancers display high levels of glutathione (GSH) and consequently, its depletion by L-buthionine sulfoximine (BSO), has been proposed as a chemosensitizing therapy. To investigate the role of GSH and of...

article

Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

Sabrina Piras, Lorenzo Brondolo, Anna Lisa Furfaro, Mario Passalacqua, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S80

Neuronal adaptation to oxidative stress is crucial to prevent degenerative diseases. The role of the Nrf2/HO-1 system in cell response to hydrogen peroxide (H₂O₂) has been investigated using SH-SY5Y neuroblastoma cells as undifferentiated or after differentiation with all-trans retinoic acid (ATRA). We showed that undifferentiated cells resisted to oxidative stimulus and up-regulated HO-1 which was...

article

A2A‐D2 receptor–receptor interaction modulates gliotransmitter release from striatal astrocyte processes

Chiara Cervetto, Arianna Venturini, Mario Passalacqua, Diego Guidolin, more

Journal of Neurochemistry > 140 > 2 > 268 - 279

Evidence for striatal A2A‐D2 heterodimers has led to a new perspective on molecular mechanisms involved in schizophrenia and Parkinson's disease. Despite the increasing recognition of astrocytes’ participation in neuropsychiatric disease vulnerability, involvement of striatal astrocytes in A2A and D2 receptor signal transmission has never been explored. Here, we investigated the presence of D2 and...

article

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse

Chiara Cervetto, Laura Vergani, Mario Passalacqua, Milena Ragazzoni, more

NeuroMolecular Medicine > 2016 > 18 > 1 > 50-68

Transgenic mice overexpressing spermine oxidase (SMO) in the cerebral cortex (Dach-SMO mice) showed increased vulnerability to excitotoxic brain injury and kainate-induced epileptic seizures. To investigate the mechanisms by which SMO overexpression leads to increased susceptibility to kainate excitotoxicity and seizure, in the cerebral cortex of Dach-SMO and control mice we assessed markers for astrocyte...

article

Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes

Chiara Cervetto, Daniela Frattaroli, Arianna Venturini, Mario Passalacqua, more

Neuropharmacology > 2015 > 99 > C > 396-407

The Bergmann glia is equipped with Ca²⁺-permeable AMPA receptors for glutamate, indispensable for structural and functional relations between the Bergmann glia and parallel/climbing fibers-Purkinje cell synapses. To better understand roles for the Bergmann AMPA receptors, herein we investigate on gliotransmitter release and Ca²⁺ signals in isolated Bergmann glia processes obtained from adult rat cerebellum...

article

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics

Giovanna Sociali, Lauretta Galeno, Marco Daniele Parenti, Alessia Grozio, more

European Journal of Medicinal Chemistry > 2015 > 102 > C > 530-539

The NAD⁺-dependent sirtuin SIRT6 is highly expressed in human breast, prostate, and skin cancer where it mediates resistance to cytotoxic agents and prevents differentiation. Thus, SIRT6 is an attractive target for the development of new anticancer agents to be used alone or in combination with chemo- or radiotherapy. Here we report on the identification of novel quinazolinedione compounds with inhibitory...

article

Sural nerve biopsy and functional studies support the pathogenic role of a novel MPZ mutation

Valeria Prada, Simona Capponi, Giulia Ursino, Antonia Alberti, more

Neuropathology > 35 > 3 > 254 - 259

Our patient is a 65‐year‐old woman presenting with bilateral pes cavus, pronounced distal muscle wasting, weakness and areflexia. Electrophysiological findings included diffuse unrecordable motor and sensory responses. While the CMT phenotype was evident, the lack of family history and the severe, but unspecific electrophysiological impairment, was a challenge for genetic diagnosis. A sural nerve...

article

Monomeric Aβ1–42 and RAGE: key players in neuronal differentiation

Sabrina Piras, Anna L. Furfaro, Alessandra Piccini, Mario Passalacqua, more

Neurobiology of Aging > 2014 > 35 > 6 > 1301-1308

The aggregation of amyloid-β (Aβ) peptides plays a crucial role in the onset and progression of Alzheimer's disease. Monomeric form of Aβ, indeed, could exert a physiological role. Considering the anti-oligomerization property of all-trans retinoic acid (ATRA), the involvement of monomeric Aβ1–42 in ATRA-induced neuronal differentiation has been investigated. Four-day ATRA treatment increases β-secretase...

article

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Anna Lisa Furfaro, Sabrina Piras, Mario Passalacqua, Cinzia Domenicotti, more

BBA - Molecular Basis of Disease > 2014 > 1842 > 4 > 613-622

High-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance. Considering the involvement of the nuclear factor-erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1) in the antioxidant and detoxifying ability of cancer cells, in this study we have investigated...

article

IGF-IR internalizes with CAVEOLIN-1 and PTRF/CAVIN in HACAT cells

Barbara Salani, Mario Passalacqua, Sara Maffioli, Lucia Briatore, more

Nutrition, Metabolism and Cardiovascular Diseases > 2013 > 23 > Supplement 1 > S53

article

The 2-arachidonoylglycerol effect on myosin light chain phosphorylation in human platelets

Maria Grazia Signorello, Enrica Giacobbe, Mario Passalacqua, Giuliana Leoncini

Biochimie > 2013 > 95 > 8 > 1620-1628

In human platelets the endocannabinoid 2-arachidonoylglycerol (2-AG) stimulates some important pathways leading to thromboxane B ₂ formation, calcium intracellular elevation, ATP secretion and actin polymerisation. The aim of the present study was to examine the 2-AG effect on myosin light chain (MLC) phosphorylation and to investigate the mechanisms involved. We demonstrated that 2-AG induced...

article

The P2X7 receptor as a route for non‐exocytotic glutamate release: dependence on the carboxyl tail

Chiara Cervetto, Susanna Alloisio, Daniela Frattaroli, Maria Chiara Mazzotta, more

Journal of Neurochemistry > 124 > 6 > 821 - 831

P2X7 receptors trigger Ca²⁺‐dependent exocytotic glutamate release, but also function as a route for non‐exocytotic glutamate release from neurons or astrocytes. To gain an insight into the mechanisms involving the P2X7 receptor as a direct pathway for glutamate release, we compared the behavior of a full‐length rat P2X7 receptor, a truncated rat P2X7 receptor in which the carboxyl tail had been deleted,...

article

Gain of glycosylation: A new pathomechanism of myelin protein zero mutations

Valeria Prada, Mario Passalacqua, Maria Bono, Paola Luzzi, more

Annals of Neurology > 71 > 3 > 427 - 431

We report the first case of a missense mutation in MPZ causing a gain of glycosylation in myelin protein zero, the main protein of peripheral nervous system myelin. The patient was affected by a severe demyelinating neuropathy caused by a missense mutation, D32N, that created a new glycosylation sequence. We confirmed that the mutant protein is hyperglycosylated, is partially retained into the Golgi...

article

The anandamide effect on NO/cGMP pathway in human platelets

Maria Grazia Signorello, Enrica Giacobbe, Mario Passalacqua, Giuliana Leoncini

Journal of Cellular Biochemistry > 112 > 3 > 924 - 932

In this study the effect of the endocannabinoid anandamide on platelet nitric oxide (NO)/cGMP pathway was investigated. Data report that anandamide in a dose‐and time‐dependent manner increased NO and cGMP levels and stimulated endothelial nitric oxide synthase (eNOS) activity. These parameters were significantly reduced by LY294002, selective inhibitor of PI3K and by MK2206, specific inhibitor of...

article

Cell–cell bond modulates vascular smooth muscle cell responsiveness to Angiotensin II

Chiara Barisione, Marzia Mura, Silvano Garibaldi, Patrizia Fabbi, more

Biochemical and Biophysical Research Communications > 2009 > 388 > 3 > 523-528

Cell attachment is provided by cell–matrix and cell–cell bonds, and acts as a regulator of vascular smooth muscle cell (VSMC) survival, activity and homeostasis, as well as of VSMCs response to pathogenic stimuli. In this work we elicited an exclusive cell–cell contact by culturing A7r5 VSMCs on agarose-coated wells to form floating cell clusters, and we demonstrated that a steady state with a reduced...

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INFONA - science communication portal

Search results for: Mario Passalacqua

Toxicity and inflammatory potential of mineral fibres: The contribute of released soluble metals versus cell contact direct effects

Near‐infrared laser photons induce glutamate release from cerebrocortical nerve terminals

Homocysteine and A2A-D2 Receptor-Receptor Interaction at Striatal Astrocyte Processes

Presynaptic GLP‐1 receptors enhance the depolarization‐evoked release of glutamate and GABA in the mouse cortex and hippocampus

Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells

Glutathione and the switch of aerobic metabolism collaborate for multi-drug resistance of neuroblastoma

Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

A2A‐D2 receptor–receptor interaction modulates gliotransmitter release from striatal astrocyte processes

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse

Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics

Sural nerve biopsy and functional studies support the pathogenic role of a novel MPZ mutation

Monomeric Aβ1–42 and RAGE: key players in neuronal differentiation

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

IGF-IR internalizes with CAVEOLIN-1 and PTRF/CAVIN in HACAT cells

The 2-arachidonoylglycerol effect on myosin light chain phosphorylation in human platelets

The P2X7 receptor as a route for non‐exocytotic glutamate release: dependence on the carboxyl tail

Gain of glycosylation: A new pathomechanism of myelin protein zero mutations

The anandamide effect on NO/cGMP pathway in human platelets

Cell–cell bond modulates vascular smooth muscle cell responsiveness to Angiotensin II

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