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To investigate changes in bone structure, turnover, and articular cartilage localized in subchondral bone cyst (SBC) regions associated with knee osteoarthritis (OA).Tibial plateaus (n = 97) were collected from knee OA patients during total knee arthroplasty (TKA). SBCs were identified using micro-computed tomography, and the specimens were divided into non-cyst (n = 25) and bone cyst (n = 72) groups...
The widespread clinical implementation of hamstring tendon (HT) autografts for anterior cruciate ligament (ACL) reconstruction is currently limited by the unpredictable integration of the graft with subchondral bone and a lack of devices that are capable of promoting biological fixation of HT grafts to bone. The site of HT graft fixation within the bone tunnel has been identified as the weak point...
Age-related changes in the microstructure of trabecular bone, such as decreases in trabecular number and trabecular thickness, lead to reductions in mechanical properties, such as Young's modulus and strength. Current drug therapy, such as bisphosphonate or parathyroid hormone, improves the mechanical properties of bone mainly by increasing the trabecular thickness, but not increasing the trabecular...
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