Search results for: Iwona Buraczewska

Items from 1 to 10 out of 10 results

article

Rozpoznanie częściowego napromienienia ciała przy pomocy testu mikrojądrowego

Sylwester Sommer, Iwona Buraczewska, Marcin Kruszewski

Postępy Techniki Jądrowej > 2019 > z. 2 > 30--32

Dozymetria biologiczna oprócz oszacowania wysokości dawki powinna mieć możliwość rozpoznawania czy napromienione zostało całe ciało, czy tylko jego część. Bardzo dobrze sprawdza się tutaj test chromosomów dicentrycznych, jednak prowadzone są prace również z innymi testami dozymetrycznymi. Wyniki badań wskazują, że test mikrojądrowy nie pozwala jednoznacznie na rozpoznawanie częściowego napromienienia...

article

Biological effects of mixed-ion beams. Part 1: Effect of irradiation of the CHO-K1 cells with a mixed-ion beam containing the carbon and oxygen ions

Joanna Czub, Dariusz Banaś, Janusz Braziewicz, Iwona Buraczewska, more

Applied Radiation and Isotopes > 2018 > 139 > C > 304-309

Carbon and oxygen ions were accelerated simultaneously to estimate the effect of irradiation of living cells with the two different ions. This mixed ion beam was used to irradiate the CHO-K1 cells, and a survival test was performed. The type of the effect of the mixed ion beam on the cells was determined with the isobologram method, whereby survival curves for irradiations with individual ion beams...

article

The rapid interphase chromosome assay (RICA) implementation: comparison with other PCC methods

Sylwester Sommer, Iwona Buraczewska, Katarzyna Sikorska, Teresa Bartłomiejczyk, more

Nukleonika > 2015 > 60 > 4 > 933-941

A report is presented on the advantages of the rapid interphase chromosome assay (RICA) and the difficulties that may be met while implementing this method for application in biological dosimetry. The RICA test can be applied on unstimulated human lymphocytes; this is an advantage in comparison with the dicentric chromosomes or micronucleus tests. In the former two tests, stimulated lymphocytes are...

article

Investigation of the bystander effect in CHO-K1 cells

Urszula Kaźmierczak, Dariusz Banaś, Janusz Braziewicz, Iwona Buraczewska, more

Reports of Practical Oncology & Radiotherapy > 2014 > 19 > Supplement > S37-S41

Investigation of the bystander effect in Chinese Hamster Ovary cells (CHO-K1) co-cultured with cells irradiated in the dose range of 0.1–4Gy of high LET ¹² C ions and X-rays.The radiobiological effects of charged heavy particles on a cellular or molecular level are of fundamental importance in the field of biomedical applications, especially in hadron therapy and space radiation biology.A...

article

The yield of radiation-induced micronuclei in early and late-arising binucleated cells depends on radiation quality

Christian Johannes, Anne Dixius, Mareike Pust, Reinhard Hentschel, more

Mutation Research - Genetic Toxicology and Environmental Mutagenesis > 2010 > 701 > 1 > 80-85

There are conflicting data regarding the effect of culturing time of human peripheral blood lymphocytes on the yield of chromosomal aberrations induced by sparsely ionising radiation in the G ₀ phase of the cell cycle. While some authors find that the yield of aberrations does not change with time, others find increased frequencies of aberrations with harvesting time. The reasons for the conflicting...

article

Enhanced level of micronuclei in peripheral blood lymphocytes of patients treated for restenosis with 32P endovascular brachytherapy

Andrzej Wojcik, Iwona Buraczewska, Sylwester Sommer, Kinga Brzozowska, more

Cardiovascular Revascularization Medicine > 2008 > 9 > 3 > 149-155

Restenosis is the complete occlusion of the blood vessel leading to such complications as ischemia/angina, myocardial infarction, and death. It can be managed by endovascular brachytherapy with both gamma and beta sources. Endovascular brachytherapy is performed worldwide on several thousands of cases per year. The gamma-emitter ¹⁹² Ir as well as the beta-emitters ³² P and ⁹⁰ ...

article

Sirtuin inhibition increases the rate of non-homologous end-joining of DNA double strand breaks

Maria Wojewódzka, Marcin Kruszewski, Iwona Buraczewska, Weizheng Xu, more

Acta Biochimica Polonica > 2007 > 54 > 1 > 63-69

Sirtuins (type III histone deacetylases) are an important member of a group of enzymes that modify chromatin conformation. We investigated the role of sirtuin inhibitor, GPI 19015, in double strand break (DSB) repair in CHO-K1 wt and xrs-6 mutant cells. The latter is defective in DNA-dependent protein kinase (DNA-PK)-mediated non-homologous end-joining (D-NHEJ). DSB were estimated by the neutral comet...

article

Radiosensitizing properties of novel hydroxydicarboxylatoplatinum(II) complexes with high or low reactivity with thiols: two modes of action

Iwona Grądzka, Iwona Buraczewska, Janina Kuduk-Jaworska, Anna Romaniewska, more

Chemico-Biological Interactions > 2003 > 146 > 2 > 165-177

We examined radiosensitizing properties of two novel platinum complexes (ethylenediamine(l-malato)platinum(II)), Pt1 and bis(1-ethylimidazole(l-malato)platinum(II)), Pt4. Initial double strand break (DSB) level and DSB rejoining were measured, using pulse field gel electrophoresis (PFGE) in human G1 phase lymphocytes subjected to Pt complex treatment alone and in combination with 10Gy of X-rays. Effects...

article

A modified neutral comet assay: elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody

Maria Wojewódzka, Iwona Buraczewska, Marcin Kruszewski

Mutation Research - Genetic Toxicology and Environmental Mutagenesis > 2002 > 518 > 1 > 9-20

Comet assay under neutral conditions allows the detection of DNA double-strand breaks (DSB), considered to be the biologically relevant radiation-induced lesion. In this report, we describe modifications of the neutral comet method, which simplify and facilitate its use for estimation of DNA DSB in X-irradiated mammalian cells in culture. The analysis carried out according to this protocol takes less...

article

Differential anti-proliferative properties of novel hydroxydicarboxylatoplatinum(II) complexes with high or low reactivity with thiols

Iwona Buraczewska, Elżbieta Boużyk, Janina Kuduk-Jaworska, Katarzyna Waszkiewicz, more

Chemico-Biological Interactions > 2000 > 129 > 3 > 297 - 315

We have examined the anti-proliferative effect of 13 recently synthesised platinum dicarboxylate complexes, very similar in their chemical, structural and kinetic properties to carboplatin. We used the L5178Y model: two murine lymphoma sublines, which differ in nucleotide excision repair ability and hence, in sensitivity to those platinum complexes that react with DNA. The anti-proliferative effect...

Filter options

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Iwona Buraczewska

Rozpoznanie częściowego napromienienia ciała przy pomocy testu mikrojądrowego

Biological effects of mixed-ion beams. Part 1: Effect of irradiation of the CHO-K1 cells with a mixed-ion beam containing the carbon and oxygen ions

The rapid interphase chromosome assay (RICA) implementation: comparison with other PCC methods

Investigation of the bystander effect in CHO-K1 cells

The yield of radiation-induced micronuclei in early and late-arising binucleated cells depends on radiation quality

Enhanced level of micronuclei in peripheral blood lymphocytes of patients treated for restenosis with 32P endovascular brachytherapy

Sirtuin inhibition increases the rate of non-homologous end-joining of DNA double strand breaks

Radiosensitizing properties of novel hydroxydicarboxylatoplatinum(II) complexes with high or low reactivity with thiols: two modes of action

A modified neutral comet assay: elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody

Differential anti-proliferative properties of novel hydroxydicarboxylatoplatinum(II) complexes with high or low reactivity with thiols

Filter options

Publication date

Publication language

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Iwona Buraczewska

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Publication language

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options