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Following our pilot study, we measured gonadotropin release in response to naloxone challenge in 17 female and 19 male neuroleptic-free, physically well, psychotic patients and compared them with age, sex and menstrual cycle phase matched controls. A total of six 10ml blood samples were taken at 20 min intervals via a peripheral intravenous cannula. Two baseline samples were followed by administration...
Researchers analysing gender differences in the pharmacodynamics and pharmacokinetics of neuroleptic drugs have reported better overall improvement of psychosis in women compared with men and generally higher drug plasma levels in female patients. (Yonkers et al. 1992) * .In this study, Brief Psychiatric Rating Scale (BPRS) data on 19 male and 21 female psychotic patients was correlated with...
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