Search results for: Patrick Adlercreutz

Items from 1 to 20 out of 101 results

article

Synthesis of glycophospholipid conjugates with mono‐ and disaccharides by enzymatic transphosphatidylation

Nikolina Barchan, Patrick Adlercreutz

European Journal of Lipid Science and Technology > 126 > 3 > n/a - n/a

Phospholipids, PLs, are interesting and highly abundant amphiphilic molecules, which self‐assemble into 3D nanostructures that have big interest as formulation excipients in, for example, pharma industry. However, the structures that are formed by naturally occurring PLs usually suffer from rigidity problems, and the nanostructures have to be modified in various ways for improved stability. One such...

article

Effects of Lipase Immobilization Conditions and Support Materials for the Production of Structured Triacylglycerols

Ariana Causevic, Kim Olofsson, Patrick Adlercreutz, Carl Grey

European Journal of Lipid Science and Technology > 125 > 2 > n/a - n/a

Structured triacylglycerols (STAG) with desired properties can be synthesized by transesterification using immobilized lipases. Herein, the effect of immobilization conditions and support material on the immobilization yield, specific activity and regioselectivity of lipases from Rhizomucor miehei (RML) and Rhizopus oryzae (ROL) in the production of STAG, are evaluated. Four different support materials...

article

Synthesis of novel oligomeric anionic alkyl glycosides using laccase/TEMPO oxidation and cyclodextrin glucanotransferase (CGTase)‐catalyzed transglycosylation

Ngoc T. N. Ngo, Javier A. Linares‐Pastén, Carl Grey, Patrick Adlercreutz

Biotechnology and Bioengineering > 118 > 7 > 2548 - 2558

Modification of alkyl glycosides, to alter their properties and widen the scope of potential applications, is of considerable interest. Here, we report the synthesis of new anionic alkyl glycosides with long carbohydrate chains, using two different approaches: laccase/2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) oxidation of a long‐carbohydrate‐chain alkyl glycoside and cyclodextrin glucanotransferase...

article

Polar Lipids Reduce In Vitro Duodenal Lipolysis Rate of Oat Oil and Liquid Oat Base Products

Jenny Lindberg Yilmaz, Patrick Adlercreutz, Cecilia Tullberg

European Journal of Lipid Science and Technology > 123 > 3 > n/a - n/a

Alternative ways for increased appetite control are today widely sought for due to the growing global health issues connected to obesity. In in vivo studies, oat has been proven an attractive candidate for inducing satiety. Oat is rich in polar lipids, of which the galactolipids are especially interesting, and a hypothesis is that these lipids play an important role for the ileal brake mechanism....

article

Endo-xylanases as tools for production of substituted xylooligosaccharides with prebiotic properties

Eva Nordberg Karlsson, Eva Schmitz, Javier A. Linares-Pastén, Patrick Adlercreutz

Applied Microbiology and Biotechnology > 2018 > 102 > 21 > 9081-9088

Xylan has a main chain consisting of β-1,4-linked xylose residues with diverse substituents. Endoxylanases cleave the xylan chain at cleavage sites determined by the substitution pattern and thus give different oligosaccharide product patterns. Most known endoxylanases belong to glycoside hydrolase (GH) families 10 and 11. These enzymes work well on unsubstituted xylan but accept substituents in certain...

article

β-Mannanase-catalyzed synthesis of alkyl mannooligosides

Johan Morrill, Anna Månberger, Anna Rosengren, Polina Naidjonoka, more

Applied Microbiology and Biotechnology > 2018 > 102 > 12 > 5149-5163

β-Mannanases catalyze the conversion and modification of β-mannans and may, in addition to hydrolysis, also be capable of transglycosylation which can result in enzymatic synthesis of novel glycoconjugates. Using alcohols as glycosyl acceptors (alcoholysis), β-mannanases can potentially be used to synthesize alkyl glycosides, biodegradable surfactants, from renewable β-mannans. In this paper, we investigate...

article

Arabinoxylanase from glycoside hydrolase family 5 is a selective enzyme for production of specific arabinoxylooligosaccharides

Peter Falck, Javier A. Linares-Pastén, Eva Nordberg Karlsson, Patrick Adlercreutz

Food Chemistry > 2018 > 242 > C > 579-584

An arabinose specific xylanase from glycoside hydrolase family 5 (GH5) was used to hydrolyse wheat and rye arabinoxylan, and the product profile showed that it produced arabinose substituted oligosaccharides (AXOS) having 2–10 xylose residues in the main chain but no unsubstituted xylooligosaccharides (XOS). Molecular modelling showed that the active site has an open structure and that the hydroxyl...

article

Xylo- and arabinoxylooligosaccharides from wheat bran by endoxylanases, utilisation by probiotic bacteria, and structural studies of the enzymes

Sindhu Mathew, Anna Aronsson, Eva Nordberg Karlsson, Patrick Adlercreutz

Applied Microbiology and Biotechnology > 2018 > 102 > 7 > 3105-3120

Xylooligosaccharides (XOS) and arabinoxylooligosaccharides (AXOS) were produced from the insoluble arabinoxylan fraction of pretreated wheat bran by endoxylanases. The glycoside hydrolase (GH) family 10 xylanases GsXyn10A from Geobacillus stearothermophilus and RmXyn10A-CM from Rhodothermus marinus produced the AXOS A³X, A²XX and A^2 + 3XX in addition to XOS. RmXyn10A-CM also produced XA^2 + 3XX due...

article

Exploring substrate specificities of a recombinant Rhizopus oryzae lipase in biodiesel synthesis

Albert Canet, M. Dolors Benaiges, Francisco Valero, Patrick Adlercreutz

New Biotechnology > 2017 > 39 > PA > 59-67

The alcoholysis of triolein was used to explore the specific features of a recombinant Rhizopus oryzae lipase (rROL) for biodiesel synthesis. For this purpose, different acylglycerols were compared as substrates in lipase-catalysed transesterification. rROL was shown to exhibit a higher specificity towards 1-monoolein than triolein compared to other R. oryzae lipases, being more than 4-fold more specific;...

article

Extraction of soluble arabinoxylan from enzymatically pretreated wheat bran and production of short xylo-oligosaccharides and arabinoxylo-oligosaccharides from arabinoxylan by glycoside hydrolase family 10 and 11 endoxylanases

Sindhu Mathew, Eva Nordberg Karlsson, Patrick Adlercreutz

Journal of Biotechnology > 2017 > 260 > C > 53-61

The enzymatic, ecofriendly pretreatment of wheat bran with α-amylase from Bacillus amyloliquifaciens or B. licheniformis at 90°C for 1.5h followed by Neutrase at 50°C for 4h, aqueous liquefaction at 121°C for 15h and ethanol precipitation enabled the production of soluble arabinoxylan (AX) with purity of 70.9% and 68.4% (w/w) respectively. Process alternatives tried, to simplify the process and curtail...

article

Application of iterative robust model‐based optimal experimental design for the calibration of biocatalytic models

Timothy Van Daele, Krist V. Gernaey, Rolf H. Ringborg, Tim Börner, more

Biotechnology Progress > 33 > 5 > 1278 - 1293

The aim of model calibration is to estimate unique parameter values from available experimental data, here applied to a biocatalytic process. The traditional approach of first gathering data followed by performing a model calibration is inefficient, since the information gathered during experimentation is not actively used to optimize the experimental design. By applying an iterative robust model‐based...

article

Three‐dimensional structures and functional studies of two GH43 arabinofuranosidases from Weissella sp. strain 142 and Lactobacillus brevis

Javier A. Linares‐Pastén, Peter Falck, Khalil Albasri, Sven Kjellström, more

The FEBS Journal > 284 > 13 > 2019 - 2036

Arabinofuranosidases degrade arabinose‐containing oligo and polysaccharides, releasing l‐arabinose, which is a potentially useful sugar, shown to reduce glycemic response under certain conditions. Arabinofuranosidases (Arafs) are frequently found in GH43, one of the most common GH‐families encoded in genomes in gut microbiota, and hence it is of interest to increase understanding of the function...

article

Development of in situ product removal strategies in biocatalysis applying scaled‐down unit operations

Søren Heintz, Tim Börner, Rolf H. Ringborg, Gustav Rehn, more

Biotechnology and Bioengineering > 114 > 3 > 600 - 609

An experimental platform based on scaled‐down unit operations combined in a plug‐and‐play manner enables easy and highly flexible testing of advanced biocatalytic process options such as in situ product removal (ISPR) process strategies. In such a platform, it is possible to compartmentalize different process steps while operating it as a combined system, giving the possibility to test and characterize...

article

Comparison of lipases and glycoside hydrolases as catalysts in synthesis reactions

Patrick Adlercreutz

Applied Microbiology and Biotechnology > 2017 > 101 > 2 > 513-519

Lipases and glycoside hydrolases have large similarities concerning reaction mechanisms. Acyl-enzyme intermediates are formed during lipase-catalyzed reactions and in an analogous way, retaining glycoside hydrolases form glycosyl-enzyme intermediates during catalysis. In both cases, the covalent enzyme intermediates can react with water or other nucleophiles containing hydroxyl groups. Simple alcohols...

article

Acyl migration in enzymatic interesterification of triacylglycerols: Effects of lipases from Thermomyces lanuginosus and Rhizopus oryzae, support material, and water activity

Xi Cao, Juan Mangas‐Sánchez, Fengqin Feng, Patrick Adlercreutz

European Journal of Lipid Science and Technology > 118 > 10 > 1579 - 1587

The enzymatic interesterification of a solvent‐free, equimolar mixture of trilaurin and 1,3‐palmitin‐2‐olein was studied using three immobilized lipase preparations as catalysts. Analysis of triacylglycerol (TAG) content and fatty acid (FA) distribution monitored the lipase‐catalyzed interesterification in sn‐1,3 positions and FA exchange in the sn‐2 position caused by acyl migration. Lipase from...

article

Eliminating hydrolytic activity without affecting the transglycosylation of a GH1 β-glucosidase

Pontus Lundemo, Eva Nordberg Karlsson, Patrick Adlercreutz

Applied Microbiology and Biotechnology > 2017 > 101 > 3 > 1121-1131

Unveiling the determinants for transferase and hydrolase activity in glycoside hydrolases would allow using their vast diversity for creating novel transglycosylases, thereby unlocking an extensive toolbox for carbohydrate chemists. Three different amino acid substitutions at position 220 of a GH1 β-glucosidase from Thermotoga neapolitana caused an increase of the ratio of transglycosylation to hydrolysis...

article

Standardized method for the Holmen pellet tester (NHP100) as a tool for evaluating the physical quality of fish feed

Julia Wolska, Olle Holst, Patrick Adlercreutz, Jan Jonkers

Aquaculture Research > 47 > 6 > 1790 - 1796

The fish feed production industry requires reliable methods measuring the physical quality of feed before it is being released to the customer. The Holmen pellet tester (NHP 100) could be adapted for this purpose, but the special characteristics of fish feed require particular care during testing. The aim of the study was to determine the standardized conditions for using the Holmen tester as a tool...

article

Combination of modern plant breeding and enzyme technology to obtain highly enriched erucic acid from Crambe oil

Natalia Volkova, Xueyuan Li, Li-Hua Zhu, Patrick Adlercreutz

Sustainable Chemical Processes > 2016 > 4 > 1 > 1-5

Background Fatty acids from vegetable oils are useful building blocks for industrial materials. The purpose of this work was to prepare erucic acid with high purity from a vegetable oil. High purity erucic acid is used for the production of erucamide with applications in plastics manufacturing. A newly developed transgenic Crambe line produces seed oil with 68 % erucic acid compared to 53 % in the...

article

An improved process for biocatalytic asymmetric amine synthesis by in situ product removal using a supported liquid membrane

Gustav Rehn, Bianca Ayres, Patrick Adlercreutz, Carl Grey

Journal of Molecular Catalysis. B, Enzymatic > 2016 > 123 > Complete > 1-7

Chiral amines are important building blocks in the pharmaceutical industry, and the biocatalytic synthesis of these compounds using ω-transaminases has been increasingly studied in recent years. In principal, asymmetric synthesis of chiral amines from a prochiral ketone is the preferable route, but it is often hampered by an unfavourable equilibrium position and product inhibition. An effective method...

article

Enzymatic preparation of oligosaccharides by transglycosylation: A comparative study of glucosidases

Juan Mangas-Sánchez, Patrick Adlercreutz

Journal of Molecular Catalysis B: Enzymatic > 2015 > 122 > C > 51-55

Five glucosidases were studied with respect to their ability to catalyse the transglycosylation of maltose or cellobiose. Experiments were carried out at high substrate concentrations to increase the ratio between transglycosylation and hydrolysis. The properties of the enzymes were quite different, and as a simple descriptor of transglycosylation ability we suggest the use of the acceptor concentration...

Publication date

Last year (1)
Last 3 years (2)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Content availability

Available (89)
None (12)

Keywords

Data set

Elsevier (64)
Springer (19)
Wiley (16)
ACS (2)

Journal

Enzyme and Microbial Technology (14)
Journal of Molecular Catalysis. B, Enzymatic (10)
European Journal of Lipid Science and Technology (9)
Journal of Biotechnology (9)
Biotechnology Letters (7)
Applied Microbiology and Biotechnology (5)
Chemistry and Physics of Lipids (4)
Process Biochemistry (4)
BBA - Proteins and Proteomics (3)
Biotechnology and Bioengineering (3)
Food Chemistry (3)
Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology (2)
Bioorganic & Medicinal Chemistry (2)
Bioresource Technology (2)
Journal of Agricultural and Food Chemistry (2)
Journal of the American Oil Chemists' Society (2)
Sustainable Chemical Processes (2)
Aquaculture Research (1)
Biochemical Engineering Journal (1)
Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism (1)
Biotechnology Progress (1)
Biotechnology Techniques (1)
Biotechnology for Biofuels (1)
Carbohydrate Polymers (1)
FEBS Letters (1)
FEMS Microbiology Letters (1)
Industrial Crops & Products (1)
Journal of Chromatography B (1)
Journal of Molecular Catalysis B: Enzymatic (1)
LWT - Food Science and Technology (1)
Lipids (1)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis (1)
New Biotechnology (1)
Phytochemistry (1)
The FEBS Journal (1)
more

INFONA - science communication portal

Search results for: Patrick Adlercreutz

Synthesis of glycophospholipid conjugates with mono‐ and disaccharides by enzymatic transphosphatidylation

Effects of Lipase Immobilization Conditions and Support Materials for the Production of Structured Triacylglycerols

Synthesis of novel oligomeric anionic alkyl glycosides using laccase/TEMPO oxidation and cyclodextrin glucanotransferase (CGTase)‐catalyzed transglycosylation

Polar Lipids Reduce In Vitro Duodenal Lipolysis Rate of Oat Oil and Liquid Oat Base Products

Endo-xylanases as tools for production of substituted xylooligosaccharides with prebiotic properties

β-Mannanase-catalyzed synthesis of alkyl mannooligosides

Arabinoxylanase from glycoside hydrolase family 5 is a selective enzyme for production of specific arabinoxylooligosaccharides

Xylo- and arabinoxylooligosaccharides from wheat bran by endoxylanases, utilisation by probiotic bacteria, and structural studies of the enzymes

Exploring substrate specificities of a recombinant Rhizopus oryzae lipase in biodiesel synthesis

Extraction of soluble arabinoxylan from enzymatically pretreated wheat bran and production of short xylo-oligosaccharides and arabinoxylo-oligosaccharides from arabinoxylan by glycoside hydrolase family 10 and 11 endoxylanases

Application of iterative robust model‐based optimal experimental design for the calibration of biocatalytic models

Three‐dimensional structures and functional studies of two GH43 arabinofuranosidases from Weissella sp. strain 142 and Lactobacillus brevis

Development of in situ product removal strategies in biocatalysis applying scaled‐down unit operations

Comparison of lipases and glycoside hydrolases as catalysts in synthesis reactions

Acyl migration in enzymatic interesterification of triacylglycerols: Effects of lipases from Thermomyces lanuginosus and Rhizopus oryzae, support material, and water activity

Eliminating hydrolytic activity without affecting the transglycosylation of a GH1 β-glucosidase

Standardized method for the Holmen pellet tester (NHP100) as a tool for evaluating the physical quality of fish feed

Combination of modern plant breeding and enzyme technology to obtain highly enriched erucic acid from Crambe oil

An improved process for biocatalytic asymmetric amine synthesis by in situ product removal using a supported liquid membrane

Enzymatic preparation of oligosaccharides by transglycosylation: A comparative study of glucosidases

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Patrick Adlercreutz

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options