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During the subacute phase of ischemia, electrophysiological alterations and cellular uncoupling set the stage for reentry. In the present work, we have developed a computational model of a fiber and a ring composed by Purkinje cells coupled to a ventricular fiber, which includes a 1B ischemic zone, a border zone and a normal zone. Simulations have been conducted to analyze the effects of cellular...
A computer model has been developed to study the electrical activity of a Purkinje fiber of 1.5 cm coupled to a regionally 1B ischemic ventricular fiber of 3 cm through a Purkinje-muscle resistance (Rpvj). The ventricular fiber was composed of a 1B ischemic zone, a border zone and a normal zone of 1 cm each. To simulate ischemia, we altered several electrophysiological parameters of the Luo-Rudy action...
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