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Ein beschleunigter Transport von Cas9/sgRNA in Zellen beruht auf funktionalisierten Nanomotoren mit Ultraschallantrieb. In ihrer Zuschrift auf S. 2687 zeigen J. Wang, L. Zhang et al., dass diese akustischen Nanomotoren schnell die Membran GFP‐exprimierender Zellen durchdringen. Einmal in die Zelle gelangt, wird die Cas9/sgRNA‐Fracht unter Einwirkung der reduzierenden Umgebung in das Zytosol freigesetzt,...
Direct and rapid intracellular delivery of a functional Cas9/sgRNA complex using ultrasound‐powered nanomotors is reported. The Cas9/sgRNA complex is loaded onto the nanomotor surface through a reversible disulfide linkage. A 5 min ultrasound treatment enables the Cas9/sgRNA‐loaded nanomotors to directly penetrate through the plasma membrane of GFP‐expressing B16F10 cells. The Cas9/sgRNA is released...
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