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Small Animal Screening
In article number 2200319, Hang Lu and co‐workers develop a droplet‐based microfluidic platform for the screening of dynamic phenotypes in small animals. The microfluidic liquid exchanger unit illustrated here allows switching of the chemical environment of an animal encapsulated in a droplet. This method represents an efficient way of altering the chemical or biological environment...
Screening functional phenotypes in small animals is important for genetics and drug discovery. Multiphase microfluidics has great potential for enhancing throughput but has been hampered by inefficient animal encapsulation and limited control over the animal's environment in droplets. Here, a highly efficient single‐animal encapsulation unit, a liquid exchanger system for controlling the droplet chemical...
Cell and islet microencapsulation in synthetic hydrogels provides an immunoprotective and cell‐supportive microenvironment. A microfluidic strategy for the genaration of biofunctionalized, synthetic microgel particles with precise control over particle size and molecular permeability for cell and protein delivery is presented. These engineered capsules support high cell viability and function of encapsulated...
We report here on an original “glass-PDMS-glass” electrochemiluminescence optofluidic device that integrates 32 electrodes on a large surface. This organic electrically powered light source has been integrated on chip using an alternative process based on a photopatternable silicone resist. Under a continuous flow rate, this device allows electrogenerated chemiluminescence for several minutes which...
An original method based on a microfluidic dye laser has been investigated to carry out optical analysis of microfluidic droplets. Droplets that have been the subject of extensive works over the last five years appear as the best tool to manipulate subnanoliter volumes for a lot of applications in both chemistry and biology. We have designed a device that combines a microfluidic dye laser and a droplet...
An original method is investigated to carry out optic analysis of microfluidic droplets using emission of a microfluidic dye laser. Multicoulour laser lines are obtained by controlling the flow rate of a dye mixture which allows to achieve a wavelength on-demand system for absorption analysis of biochemical samples in droplets.
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