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Thioacetamide (TA) is a model hepatotoxin that undergoes metabolic activation via two successive S‐oxidations. The ultimate toxic metabolite thioacetamide S,S‐dioxide, or its tautomer acetimidoyl sulfinic acid CH3C(NH)SO2H, then acylates lysine side chains on cellular proteins leading to cellular dysfunction or death. To identify individual target proteins, quantitate the extent of their modification...
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