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Little is known whether and how chronic exposure to dopaminergic treatment alters physiological mechanisms in Parkinson’s disease (PD).Two clinically similar groups of PD patients, one consisting of drug-naïve patients and another of patients already on chronic dopaminergic medication (when off medication), were compared to each other and to a control group. Plasticity and excitability of the hand...
Background and purposeTo screen for glucocerebrosidase (GBA) mutations in a Serbian Parkinson's disease (PD) population.
MethodsGlucocerebrosidase exons 8–11 harbouring the most common mutations were sequenced in 360 patients with PD and 348 controls from Serbia. Haplotype analysis was performed for the N370S mutation and compared with German and Ashkenazi Jewish carriers.
ResultsGlucocerebrosidase...
The gait disturbances in Parkinson's disease (PD) patients occur occasionally and intermittently, appearing in a random, inexplicable manner. These disturbances include festinations, shuffling, and complete freezing of gait (FOG). Alternation of walking pattern decreases the quality of life and may result in falls. In order to recognize disturbances during walking in PD patients, we recorded gait...
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