Search results for: Wojciech Nitek

Items from 1 to 20 out of 62 results

article

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation

Gabriela Mazur, Katarzyna Pańczyk‐Straszak, Anna Rapacz, Jan Kiszela, more

Chemical Biology & Drug Design > 101 > 2 > 278 - 325

A series of 10 aminoalkanol derivatives of 5‐chloro‐2‐ or 5‐chloro‐4‐methylxanthone was synthetized and evaluated for anticonvulsant properties (MES test, mice, intraperitoneal) and compared with neurotoxicity rotarod test (NT, mice, i.p.). The best results both in terms of anticonvulsant activity and protective index value were obtained for 3: 5‐chloro‐2‐([4‐hydroxypiperidin‐1‐yl]methyl)‐9H‐xanthen‐9‐one...

article

A Porous Sulfonated 2D Zirconium Metal–Organic Framework as a Robust Platform for Proton Conduction

Monika Szufla, Aleksandra Choroś, Wojciech Nitek, Dariusz Matoga

Chemistry – A European Journal > 28 > 37 > n/a - n/a

By using the strategy of pre‐assembly chlorosulfonation applied to a linker precursor, the first sulfonated zirconium metal–organic framework (JUK‐14) with two‐dimensional (2D) structure, was synthesized. Single‐crystal X‐ray diffraction reveals that the material is built of Zr₆O₄(OH)₄(COO)₈ oxoclusters, doubly 4‐connected by angular dicarboxylates, and stacked in layers spaced 1.5 nm apart by the...

article

Pharmacophoric features for a very potent 5‐spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X‐ray analysis

Ewa Żesławska, Annamária Kincses, Gabriella Spengler, Wojciech Nitek, more

Chemical Biology & Drug Design > 93 > 5 > 844 - 853

In order to extend knowledge about pharmacophoric features responsible for ABCB1 inhibitory properties of imidazolidin‐2,4‐dione derivatives, 1′‐[4‐(4‐(o‐methoxyphenyl)‐piperazin‐1‐yl)butyl]‐3′‐methyl‐spiro(fluoren‐9,5′‐imidazolidine)‐2′,4′‐dione (3) and its salt (4) with rhodanine‐3‐acetic acid (RA) were prepared and investigated by X‐ray diffraction method, as well as their efflux modulating effects...

article

Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives

Iwona Stawoska, Waldemar Tejchman, Olga Mazuryk, Antonín Lyčka, more

Journal of Heterocyclic Chemistry > 54 > 5 > 2889 - 2897

Selected rhodanine‐3‐carboxylic acids derivatives were synthesized to determine the influence of the structure and the length of the linker between the carboxyl group and the nitrogen atom (N‐3) in the 2‐thioxo‐4‐thiazolidinone ring on their activity, monitored via interactions with human serum albumin. Based on fluorescence studies, we concluded that the length of the linker has a limited impact...

article

Physicochemical and biological evaluation of a cinnamamide derivative R,S‐(2E)‐1‐(3‐hydroxypiperidin‐1‐yl)‐3‐phenylprop‐2‐en‐1‐one (KM‐608) for nervous system disorders

Agnieszka Gunia‐Krzyżak, Ewa Żesławska, Florence M. Bareyre, Wojciech Nitek, more

Chemical Biology & Drug Design > 90 > 2 > 244 - 253

A cinnamamide scaffold has been successfully incorporated in several compounds possessing desirable pharmacological activities in central and peripheral nervous system such as anticonvulsant, antidepressant, neuroprotective, analgesic, anti‐inflammatory, muscle relaxant, and sedative/hypnotic properties. R,S‐(2E)‐1‐(3‐hydroxypiperidin‐1‐yl)‐3‐phenylprop‐2‐en‐1‐one (KM‐608), a cinnamamide derivative,...

article

Crystal structure, phase transitions and vibrations of H₂O molecules in [Ca(H₂O)₂](ReO₄)₂

Joanna Hetmańczyk, Łukasz Hetmańczyk, Wojciech Nitek

Journal of Thermal Analysis and Calorimetry > 2018 > 131 > 1 > 479-489

One reversible phase transition at $$T_{\text{c}}^{{\text{h}}}$$ T c h = 261.2 K (upon heating) was observed for [Ca(H₂O)₂](ReO₄)₂ in the 120–300 K range. Thermal hysteresis of the phase transition temperature T_C of ca. 30 K and heat flow anomaly sharpness suggest that the detected phase transition is of a first-order type. The entropy change value (ΔS ≈ 1.6 ± 0.08 J mol⁻¹ K⁻¹), associated...

article

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3

Agnieszka Gunia-Krzyżak, Dorota Żelaszczyk, Anna Rapacz, Ewa Żesławska, more

Bioorganic & Medicinal Chemistry > 2017 > 25 > 2 > 471-482

A series of twenty two (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH₃ or 2-CH₃ was designed, synthesized and evaluated for anticonvulsant activity in rodent models of seizures: maximal electroshock (MES) test, subcutaneous pentylenetetrazole (scPTZ) test, and 6-Hz test. There were identified three most active compounds: S-(2E)-N-(1-hydroxypropan-2-yl)-3-(2-methylphenyl)prop-2-enamide...

article

Solvatomagnetic Studies on Cyano‐Bridged Bimetallic Chains Based on [Mn(cyclam)]³⁺ and Hexacyanometallates

Beata Nowicka, Michał Heczko, Michał Rams, Mateusz Reczyński, more

European Journal of Inorganic Chemistry > 2017 > 1 > 99 - 106

Structures and solvatomagnetic properties of two 1D CN‐bridged assemblies based on the complex [Mn(cyclam)]³⁺ (cyclam = 1,4,8,11‐tetraazacyclotetradecane) were characterised. The isostructural {[Mn(cyclam)][Cr(CN)₆]·6H₂O}_n (1·6H₂O) and {[Mn(cyclam)][Fe(CN)₆]·6H₂O}_n (2·6H₂O) chains crystallise in the space group C2/m. When dried in air at a slightly elevated temperature the hexahydrates undergo irreversible...

article

Structure dependent charge transfer in bipyrimidinium–octacyanotungstate ion pairs

Beata Nowicka, Wojciech Nitek, Piotr Pietrzyk, Barbara Sieklucka

Polyhedron > 2016 > 119 > C > 1-6

Two solid state forms of the {(bpymH₂)²⁺,[W^IV(CN)₈]⁴⁻} charge-transfer ion pair have been obtained in the reaction between 2,2′-bipyrimidine (bpym) and octacyanotungstate(IV) in acidic solution and characterised in terms of structure and spectroscopic properties: (bpymH₂)₂[W^IV(CN)₈]·4H₂O (1) and (PPh₄)₂(bpymH₂)[W^IV(CN)₈]·10H₂O (2). In contrast to the yellow potassium salt, compound 1 is red and shows...

article

Cobalt(II) compounds with acetone isonicotinoyl hydrazone tautomers: Syntheses and crystal structures of complexes with free donor atoms

Kornel Roztocki, Dariusz Matoga, Wojciech Nitek

Inorganica Chimica Acta > 2016 > 448 > C > 86-92

Complexes with free donor atoms, as potential metalloligands, are important building blocks in crystal engineering of coordination polymers and metal organic frameworks. In this work, the possibility of formation of cobalt(II) complexes with free N-donor atoms based on acetone isonicotinoyl hydrazone (Hisn), is verified. Syntheses, X-ray crystal structures and spectroscopic properties of two new cobalt(II)...

article

The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies

Ewa Żesławska, Annamária Kincses, Gabriella Spengler, Wojciech Nitek, more

Bioorganic & Medicinal Chemistry > 2016 > 24 > 12 > 2815-2822

A series of arylpiperazine derivatives of hydantoin-3-acetate, including previously obtained 5,5-diphenylhydantoin (1–7) and new-synthesized spirofluorene-hydantoin derivatives (8–12), were investigated in the search for new inhibitors of the tumour multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp, ABCB1) overexpressed in mouse T-lymphoma cells. Synthesis of new compounds (8–12) was performed...

article

Anticonvulsant Activity of Enantiomeric N‐trans‐Cinnamoyl Derivatives of 2‐Aminopropan‐1‐ols and 2‐Aminobutan‐1‐ols

Agnieszka Gunia‐Krzyżak, Ewa Żesławska, Wojciech Nitek, Justyna Popiół, more

Chirality > 28 > 6 > 482 - 488

Epilepsy, one of the most frequent neurological disorders, is still insufficiently treated in about 30% of patients. As a consequence, identification of novel anticonvulsant agents is an important issue in medicinal chemistry. In the present article we report synthesis, physicochemical, and pharmacological evaluation of N‐trans‐cinnamoyl derivatives of R and S‐2‐aminopropan‐1‐ol, as well as R and...

article

Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols

Agnieszka Gunia-Krzyżak, Ewa Żesławska, Karolina Słoczyńska, Paulina Koczurkiewicz, more

European Journal of Medicinal Chemistry > 2016 > 107 > Complete > 26-37

Adequate control of seizures remains an unmet need in epilepsy. In order to identify new anticonvulsant agents, a series of N-trans-cinnamoyl derivatives of selected aminoalkanols was synthetized. The compounds were obtained in the reaction of N-acylation carried out in a two-phase system. The substances were tested in animal models of seizures induced either electrically (maximal electroshock – MES;...

article

Molybdenum Complexes as Catalysts for the Oxidation of Cycloalkanes with Molecular Oxygen

Anna Szymańska, Wojciech Nitek, Marcin Oszajca, Wiesław Łasocha, more

Catalysis Letters > 2016 > 146 > 5 > 998-1010

A group of new polymolybdates was synthesized and tested in the catalytic oxidation of cycloalkanes. Investigated compounds exhibit broad structural diversity including polymolybdates with isolated anionic clusters (0-dim), polymeric anions (1-dim), Mo–O layers (2-dim) as well as hexagonal and orthorhombic molybdenum oxides (3-dim). All studied molybdenum complexes were found to be active in the reaction...

article

Crystal structures of 1,8‐bis(dimethylamino)naphthalene (DMAN) and dicarboxylic acids complexes determined from single‐crystal and powder diffraction data

Marcin Oszajca, Wojciech Nitek, Alicja Rafalska‐Łasocha, Wiesław Łasocha

Crystal Research and Technology > 50 > 9-10 > 781 - 790

New complexes of DMAN proton sponge with 3 dicarboxylic acids (dca): glutaric {1}, suberic {2} and dodecanedioic acid {3} were obtained. The structures of the complexes {1,2} were solved on the basis of laboratory powder data, while the structure of {3} was solved using single crystal methods. The additional goal of the study was to test some new approaches to organic crystal structure solution from...

article

N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols—their physicochemical and anticonvulsant properties

Anna M. Waszkielewicz, Marek Cegła, Ewa Żesławska, Wojciech Nitek, more

Bioorganic & Medicinal Chemistry > 2015 > 23 > 15 > 4197-4217

Twenty four new N-[(dimethylphenoxy)alkyl]aminoalkanols have been synthesized and evaluated for anticonvulsant activity in a series of in vivo tests: the maximum electroshock (MES), 6Hz, and subcutaneous metrazole (ScMet). The compounds were also evaluated for possible neurotoxicity in the rotarod test. The majority of the achieved compounds exhibit quantified anticonvulsant activity. The most active...

article

Synthesis, structural characterization and spectroscopy studies of new oxovanadium(IV, V) complexes with hydrazone ligands

Patrycja Paciorek, Janusz Szklarzewicz, Anna Jasińska, Bartosz Trzewik, more

Polyhedron > 2015 > 87 > Complete > 226-232

The reaction of vanadyl acetoacetonate, VO(acac) ₂ , with 2-hydroxybenzaldehyde hydrazone in ethanol gave the mononuclear oxovanadium(IV) complex [VO(salh ₁ ) ₂ ] (1). However, when the hydrazides 3-hydroxy-2-naphthoic acid hydrazide (h ₂ ) and 5-phenylisoxazole-3-carboxylicacidhydrazide (h ₃ ) were used, the mononuclear oxoethoxovanadium(V) complexes [VO(acanh...

article

N-substituted monodentate alcohols as ligands modifying structure, properties and thermal stability of Mo(IV) complexes

Anna Jurowska, Janusz Szklarzewicz, Maciej Hodorowicz, Monika Tomecka, more

Journal of Molecular Structure > 2015 > 1081 > Complete > 6-13

The reaction of N-substituted alcohols (2-aminoethanol, 3-amino-1-propanol and 2-hydroxyethylhydrazine) with K ₃ Na[Mo(CN) ₄ O ₂ ]⋅6H ₂ O in water–ethanol solution results in isolation of three new complexes of formulae: (PPh ₄ ) ₂ [Mo(CN) ₄ O(amet)]⋅3H ₂ O (1), (amet=2-aminoethanol), (PPh ₄ ) ₂ [Mo(CN) ₄ O(ampro)]⋅3H...

article

The Synthesis and Crystal Structures of the Homologues of Epalrestat

Ewa Żesławska, Wojciech Nitek, Waldemar Tejchman

Journal of Chemical Crystallography > 2015 > 45 > 3 > 151-157

Two homologues of epalrestat were synthesized and characterized by IR, MS, elemental analysis, ¹ H NMR, ¹³ C NMR and their crystal structures were determined by X-ray diffraction method. The crystals of both compounds belong to the triclinic centrosymmetric space group. In both crystal structures the carboxyl groups are involved in the strong O–H···O hydrogen bonds....

article

Mixed-valence VIV/VV tetrametallate core {V4N2O14} cluster containing tris(hydroxymethyl)aminomethane and acetylacetone

Piotr Zabierowski, Mariusz Radoń, Janusz Szklarzewicz, Wojciech Nitek

Inorganic Chemistry Communications > 2014 > 41 > Complete > 72-75

Reported is a mixed-valence V ^IV /V ^V tetrametallate cluster, which is charge neutral and stable in solution. The complex is characterized by single-crystal X-ray diffraction analysis, IR and UV–VIS–NIR absorption spectroscopy, cyclic voltammetry, room temperature magnetic susceptibility measurements and quantum chemical calculations.

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CRYSTAL STRUCTURE (12)
CINNAMAMIDE (4)
PHASE TRANSITIONS (4)
X-RAY CRYSTAL STRUCTURE (4)
ANTICONVULSANT (3)
ANTICONVULSANT ACTIVITY (3)
CRYOGENIC SOLUTIONS (3)
CYANIDE (3)
CYANIDES (3)
FILTRATION METHOD (3)
HYDRAZONE (3)
HYDROCARBONS (3)
LIQUID ARGON (3)
LIQUID NITROGEN (3)
MAGNETIC PROPERTIES (3)
MANGANESE (3)
PHYSICOCHEMICAL PROPERTIES (3)
SOLUBILITY (3)
CALORIMETRY (2)
CHARGE TRANSFER (2)
COMPLEX (2)
COPPER (2)
DIFFERENTIAL SCANNING CALORIMETRY (2)
DSC (2)
HOST–GUEST SYSTEMS (2)
IMPURITIES (2)
MAGNETISCHE EIGENSCHAFTEN (2)
MANGAN (2)
MES (2)
MUTAGENICITY (2)
NEUTRON POWDER DIFFRACTION (2)
NIOB (2)
NIOBIUM (2)
NMR (2)
OCTACYANOTUNGSTATE (2)
PHASE TRANSITION (2)
REORIENTATIONAL MOTIONS (2)
STRUCTURAL CHANGES (2)
THERMAL DECOMPOSITION (2)
TRIS(PYRAZOLYL)BORATO COMPLEXES (2)
VANADIUM (2)
WIRT‐GAST‐SYSTEME (2)
X-RAY DIFFRACTION (2)
X-RAY SINGLE CRYSTAL DIFFRACTION (2)
XRD (2)
1-HEXENE (1)
1-HEXYNE (1)
2,3-DICYANOPYRAZINE (1)
2,3-DIMETHYLBUTANE (1)
2-METHYLPENTANE (1)
2-PYRIDINECARBONITRILE (1)
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6-HZ (1)
6HZ (1)
A. INORGANIC COMPOUNDS (1)
AMES TEST (1)
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AMINOALKANOL (1)
AMINOALKANOLS (1)
AMODIAQUINE (1)
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Search results for: Wojciech Nitek

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation

A Porous Sulfonated 2D Zirconium Metal–Organic Framework as a Robust Platform for Proton Conduction

Pharmacophoric features for a very potent 5‐spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X‐ray analysis

Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives

Physicochemical and biological evaluation of a cinnamamide derivative R,S‐(2E)‐1‐(3‐hydroxypiperidin‐1‐yl)‐3‐phenylprop‐2‐en‐1‐one (KM‐608) for nervous system disorders

Crystal structure, phase transitions and vibrations of H₂O molecules in [Ca(H₂O)₂](ReO₄)₂

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3

Solvatomagnetic Studies on Cyano‐Bridged Bimetallic Chains Based on [Mn(cyclam)]³⁺ and Hexacyanometallates

Structure dependent charge transfer in bipyrimidinium–octacyanotungstate ion pairs

Cobalt(II) compounds with acetone isonicotinoyl hydrazone tautomers: Syntheses and crystal structures of complexes with free donor atoms

The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies

Anticonvulsant Activity of Enantiomeric N‐trans‐Cinnamoyl Derivatives of 2‐Aminopropan‐1‐ols and 2‐Aminobutan‐1‐ols

Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols

Molybdenum Complexes as Catalysts for the Oxidation of Cycloalkanes with Molecular Oxygen

Crystal structures of 1,8‐bis(dimethylamino)naphthalene (DMAN) and dicarboxylic acids complexes determined from single‐crystal and powder diffraction data

N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols—their physicochemical and anticonvulsant properties

Synthesis, structural characterization and spectroscopy studies of new oxovanadium(IV, V) complexes with hydrazone ligands

N-substituted monodentate alcohols as ligands modifying structure, properties and thermal stability of Mo(IV) complexes

The Synthesis and Crystal Structures of the Homologues of Epalrestat

Mixed-valence VIV/VV tetrametallate core {V4N2O14} cluster containing tris(hydroxymethyl)aminomethane and acetylacetone

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