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Curcumin (CCM; diferuoylmethane) is a dietary pigment in curry with known antineoplastic and anti-inflammatory effects. The immunosuppressive effects of CCM were studied in (1) rat heterotopic cardiac transplant models, using Brown-Norway (BN, RT1 n ) hearts to WKY (RT1 u ) hosts or Buffalo (BUF, RT1 b ) hearts to Wistar-Furth (WF, RT1 u ) hosts, (2) reverse transcriptase-polymerase...