Search results for: Florence M. Bareyre

Items from 1 to 6 out of 6 results

article

Physicochemical and biological evaluation of a cinnamamide derivative R,S‐(2E)‐1‐(3‐hydroxypiperidin‐1‐yl)‐3‐phenylprop‐2‐en‐1‐one (KM‐608) for nervous system disorders

Agnieszka Gunia‐Krzyżak, Ewa Żesławska, Florence M. Bareyre, Wojciech Nitek, more

Chemical Biology & Drug Design > 90 > 2 > 244 - 253

A cinnamamide scaffold has been successfully incorporated in several compounds possessing desirable pharmacological activities in central and peripheral nervous system such as anticonvulsant, antidepressant, neuroprotective, analgesic, anti‐inflammatory, muscle relaxant, and sedative/hypnotic properties. R,S‐(2E)‐1‐(3‐hydroxypiperidin‐1‐yl)‐3‐phenylprop‐2‐en‐1‐one (KM‐608), a cinnamamide derivative,...

article

Neuronal repair and replacement in spinal cord injury

Florence M. Bareyre

Journal of the Neurological Sciences > 2008 > 265 > 1-2 > 63-72

Spinal cord injury (SCI) often induces loss of motor and/or sensory function below the level of injury. While deficits persist in complete lesions, partial lesions of the spinal cord can be followed by spontaneous functional recovery. In this review we address the mechanisms underlying spontaneous recovery in the adult CNS. We argue that the adult brain and spinal cord are able to spontaneously respond...

article

Targeting Experimental Autoimmune Encephalomyelitis Lesions to a Predetermined Axonal Tract System Allows for Refined Behavioral Testing in an Animal Model of Multiple Sclerosis

Martin Kerschensteiner, Christine Stadelmann, Bigna S. Buddeberg, Doron Merkler, more

The American Journal of Pathology > 2004 > 164 > 4 > 1455-1469

In multiple sclerosis (MS) the structural damage to axons determines the persistent clinical deficit patients acquire during the course of the disease. It is therefore important to test therapeutic strategies that can prevent or reverse this structural damage. The conventional animal model of MS, experimental autoimmune encephalomyelitis (EAE), typically shows disseminated inflammation in the central...

article

Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays

Florence M. Bareyre, Martin E. Schwab

Trends in Neurosciences > 2003 > 26 > 10 > 555-563

GeneChip ⁽ R) microarrays have recently been introduced to the field of neurobiology to identify and monitor the expression levels of thousands of genes simultaneously. This powerful technique is now used for studying the pathophysiology of CNS injuries including spinal cord lesions. Early stages after injury are characterized by the strong upregulation of genes involved in transcription and...

article

Effects of underwater sound exposure on neurological function and brain histology

Helmut L. Laurer, Andrew N. Ritting, Andrew B. Russ, Florence M. Bareyre, more

Ultrasound in Medicine & Biology > 2002 > 28 > 7 > 965-973

To evaluate the safety of sonar exposure from a neurological perspective, the vulnerability of the central nervous system to underwater exposure with high-intensity, low-frequency sound (HI-LFS) was experimentally examined. Physiological, behavioral and histological parameters were measured in anesthetized, ventilated rats exposed to brief (5 min), underwater HI-LFS. Exposure to 180 dB sound pressure...

article

Postinjury Magnesium Treatment Attenuates Traumatic Brain Injury-Induced Cortical Induction of p53 mRNA in Rats

Judith K. Muir, Ramesh Raghupathi, Dana L. Emery, Florence M. Bareyre, more

Experimental Neurology > 1999 > 159 > 2 > 584-593

Administration of magnesium has been shown to be neuroprotective in experimental models of traumatic brain injury (TBI). The present study examined the effect of magnesium on posttraumatic regional induction of p53, a gene associated with induction of cell death. Male Sprague–Dawley rats (350–400 g, n=26) were anesthetized with sodium pentobarbital and subjected to either lateral fluid percussion...

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Search results for: Florence M. Bareyre

Physicochemical and biological evaluation of a cinnamamide derivative R,S‐(2E)‐1‐(3‐hydroxypiperidin‐1‐yl)‐3‐phenylprop‐2‐en‐1‐one (KM‐608) for nervous system disorders

Neuronal repair and replacement in spinal cord injury

Targeting Experimental Autoimmune Encephalomyelitis Lesions to a Predetermined Axonal Tract System Allows for Refined Behavioral Testing in an Animal Model of Multiple Sclerosis

Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays

Effects of underwater sound exposure on neurological function and brain histology

Postinjury Magnesium Treatment Attenuates Traumatic Brain Injury-Induced Cortical Induction of p53 mRNA in Rats

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