Search results for: Alex T. Vesey

Items from 1 to 8 out of 8 results

article

Ferumoxytol magnetic resonance angiography: a dose-finding study in patients with chronic kidney disease

Sokratis Stoumpos, Martin Hennessy, Alex T. Vesey, Aleksandra Radjenovic, more

European Radiology > 2019 > 29 > 7 > 3543-3552

Objectives Ferumoxytol is an alternative to gadolinium-based compounds as a vascular contrast agent for magnetic resonance angiography (MRA), particularly for patients with chronic kidney disease (CKD). However, dose-related efficacy data are lacking. We aimed to determine the optimal (minimum effective) dose of ferumoxytol for MRA in patients with CKD. Methods Ferumoxytol-enhanced MRA (FeMRA) was...

article

18F–Sodium Fluoride Uptake in Abdominal Aortic Aneurysms

Rachael O. Forsythe, Marc R. Dweck, Olivia M.B. McBride, Alex T. Vesey, more

Journal of the American College of Cardiology > 2018 > 71 > 5 > 513-523

Fluorine-18–sodium fluoride (¹⁸F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque.In patients with abdominal aortic aneurysm (AAA), the authors assessed whether ¹⁸F-NaF positron emission tomography (PET) and computed tomography (CT) predicts AAA growth and clinical outcomes.In prospective case-control (n = 20 per group) and longitudinal cohort...

article

Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis

Calvin W.L. Chin, Russell J. Everett, Jacek Kwiecinski, Alex T. Vesey, more

JACC: Cardiovascular Imaging > 2017 > 10 > 11 > 1320-1333

Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic stenosis, as well as their association with other measures of left ventricular decompensation and mortality.Progressive myocardial fibrosis drives the transition from hypertrophy to heart failure in aortic stenosis. Diffuse fibrosis is associated with extracellular...

article

End stage renal disease‐induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived‐matrix vesicles

Lin Cui, Nabil A. Rashdan, Dongxing Zhu, Elspeth M. Milne, more

Journal of Cellular Physiology > 232 > 11 > 2985 - 2995

Patients with end‐stage renal disease (ESRD) have elevated circulating calcium (Ca) and phosphate (Pi), and exhibit accelerated progression of calcific aortic valve disease (CAVD). We hypothesized that matrix vesicles (MVs) initiate the calcification process in CAVD. Ca induced rat valve interstitial cells (VICs) calcification at 4.5 mM (16.4‐fold; p < 0.05) whereas Pi treatment alone had no effect...

article

Ferumoxytol-enhanced magnetic resonance angiography for the assessment of potential kidney transplant recipients

Sokratis Stoumpos, Martin Hennessy, Alex T. Vesey, Aleksandra Radjenovic, more

European Radiology > 2018 > 28 > 1 > 115-123

Objectives Traditional contrast-enhanced methods for scanning blood vessels using magnetic resonance imaging (MRI) or CT carry potential risks for patients with advanced kidney disease. Ferumoxytol is a superparamagnetic iron oxide nanoparticle preparation that has potential as an MRI contrast agent in assessing the vasculature. Methods Twenty patients with advanced kidney disease requiring aorto-iliac...

article

MR Imaging of Coronary Arteries and Plaques

Marc R. Dweck, Valentina O. Puntmann, Alex T. Vesey, Zahi A. Fayad, more

JACC: Cardiovascular Imaging > 2016 > 9 > 3 > 306-316

Cardiac magnetic resonance offers the promise of radiation-free imaging of the coronary arteries, providing information with respect to luminal stenosis, plaque burden, high-risk plaque characteristics, and disease activity. In combination, this would provide a comprehensive, individualized assessment of coronary atherosclerosis that could be used to improve patient risk stratification and to guide...

article

Valvular 18F-Fluoride and 18F-Fluorodeoxyglucose Uptake Predict Disease Progression and Clinical Outcome in Patients With Aortic Stenosis

William S.A. Jenkins, Alex T. Vesey, Anoop S.V. Shah, Tania A. Pawade, more

Journal of the American College of Cardiology > 2015 > 66 > 10 > 1200-1201

article

18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial

Nikhil V Joshi, Alex T Vesey, Michelle C Williams, Anoop S V Shah, more

The Lancet > 2014 > 383 > 9918 > 705-713

The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and high-risk atherosclerotic plaques using the radioactive tracers ¹⁸F-sodium fluoride (¹⁸F-NaF) and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG). In this prospective...

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Search results for: Alex T. Vesey

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