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Cyclosporine A (CsA), a potent immunosuppressive agent, has several adverse effects on different organs including the spleen. Fucoidan is a sulfated polysaccharide extracted from marine algae and it has numerous biological activities. The present study aimed to investigate the adverse effects of CsA on the spleen of rats and to evaluate the role of fucoidan, as immune-modulator and antioxidant substance,...