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Abstract. Peroxisome proliferator activated receptor (PPAR) is a nuclear hormone receptor that has been shown to regulate differentiation and cell growth. Studies of the differentiative effects of PPAR agonists on several cancer cell lines led to the hypothesis that dysfunction of PPAR contributes to tumorigenesis. These functional observations were strengthened by genetic evidence: somatic loss-of-function...
Abstract. The glial-cell-line-derived neurotrophic factor (GDNF) family receptors alpha (GFR) are cell surface bound glycoproteins that mediate interactions of the GDNF ligand family with the RET receptor. These interactions are crucial to the development of the kidney and some peripheral nerve lineages. In humans, mutations of RET or RET ligands are associated with the congenital abnormality Hirschsprung...
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