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Previous evidence suggests that a homeostatic germinal center (GC) response may limit bortezomib desensitization therapy. We evaluated the combination of costimulation blockade with bortezomib in a sensitized non‐human primate kidney transplant model. Sensitized animals were treated with bortezomib, belatacept, and anti‐CD40 mAb twice weekly for a month (n = 6) and compared to control animals (n = 7)...
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