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A series of new pyrimido[5,4-c]quinolin-4(3H)-ones with variable length of the spacer between amide and 4-arylpiperazine moiety were prepared to further explore the role of a terminal portion in the serotonergic activity. The majority of compounds demonstrated high in vitro affinity for 5-HT 1A receptor, and moderate-to-low affinity for 5-HT 2A and 5-HT 7 receptors. X-ray analysis,...
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