Search results for: Andrzej Olczak

Items from 1 to 19 out of 19 results

article

Structural analysis and antimicrobial activity of 2[1H]-pyrimidinethione/selenone derivatives

Ewa Żesławska, Izabela Korona-Głowniak, Małgorzata Szczesio, Andrzej Olczak, more

Journal of Molecular Structure > 2017 > 1142 > C > 261-266

Four new crystal structures of sulfur and selenium analogues of 2[1H]-pyrimidinone derivatives were determined with the use of X-ray diffraction method. The molecular geometry and intermolecular interactions of the investigated molecules were analyzed in order to find the structural features and geometrical parameters, which can be responsible for antimicrobial activities. The influence of chalcogen...

article

Planarity of benzoyldithiocarbazate tuberculostatics. II. Diesters of benzoyldithiocarbazic acid

Małgorzata Szczesio, Andrzej Olczak, Katarzyna Gobis, Ida Mazerant, more

Acta Crystallographica Section C > 72 > 1 > 75 - 79

The emergence of drug‐resistant strains of Mycobacterium tuberculosis has intensified efforts to identify new lead tuberculostatics. Our earlier studies concluded that the planarity of a molecule correlates well with its tuberculostatic activity. According to our hypothesis, only derivatives whose molecules are capable of adopting a planar conformation may show tuberculostatic activity. The structures...

article

Synthesis and Biological Evaluation of New Bischromone Derivatives with Antiproliferative Activity

Agata Szulawska‐Mroczek, Marta Szumilak, Malgorzata Szczesio, Andrzej Olczak, more

Archiv der Pharmazie > 346 > 1 > 34 - 43

The synthesis of new bischromone derivatives (4a–c and 5a–c) as potential anticancer drugs is described. The difference in the reactivity between 4‐oxo‐4H‐chromene‐3‐carboxylic acid 2 (or its methyl ester 3) and 4‐oxo‐4H‐chromene‐3‐carbonyl chloride 1 with three different polyamines: 3,3′‐diamino‐N‐methyldipropylamine (a), 1,4‐bis(3‐aminopropyl)piperazine (b), 4,9‐dioxa‐1,12‐dodecanediamine (c) resulted...

article

Planarity of benzoylhydrazine–dithiocarbazoate tuberculostatics. I. N′‐Methyl‐substituted 3,4‐dichlorobenzoyl monoesters

Małgorzata Szczesio, Andrzej Olczak, Katarzyna Gobis, Henryk Foks, more

Acta Crystallographica Section C > 68 > 10 > o373 - o376

Methyl 2‐(3,4‐dichlorobenzoyl)‐1‐methylhydrazinecarbodithioate, C₁₀H₁₀Cl₂N₂OS₂, (F1), butyl 2‐(3,4‐dichlorobenzoyl)‐1‐methylhydrazinecarbodithioate, C₁₃H₁₆Cl₂N₂OS₂, (F2), and 3,4‐dichloro‐N‐(2‐sulfanylidene‐1,3‐thiazinan‐3‐yl)benzamide, C₁₁H₁₀Cl₂N₂OS₂, (F3), were studied by X‐ray diffraction to test our hypothesis that planarity of aryloylhydrazinedithiocarbazic acid esters is a prerequisite for tuberculostatic...

article

Planarity of heteroaryldithiocarbazic acid derivatives showing tuberculostatic activity. IV. Diesters of benzoylcarbonohydrazonodithioic acid

Małgorzata Szczesio, Andrzej Olczak, Katarzyna Gobis, Henryk Foks, more

Acta Crystallographica Section C > 68 > 3 > o99 - o103

Dimethyl (3,4‐dichlorobenzoyl)carbonohydrazonodithioate, C₁₀H₁₀Cl₂N₂OS₂, (D1), dibenzyl (3,4‐dichlorobenzoyl)carbonohydrazonodithioate, C₂₂H₁₈Cl₂N₂OS₂, (D2), dimethyl (3,4‐dichlorobenzoyl)‐1‐methylcarbonohydrazonodithioate, C₁₁H₁₂Cl₂N₂OS₂, (D3), 3,4‐dichloro‐N′‐(1,3‐dithiolan‐2‐ylidene)‐N‐methylbenzohydrazide, C₁₁H₁₀Cl₂N₂OS₂, (D4), were synthesized as potential tuberculostatics. Compound (D1) (with...

article

Synthesis, characterization, and tuberculostatic activity of novel 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid derivatives

Katarzyna Gobis, Henryk Foks, Ewa Augustynowicz-Kopec, Agnieszka Napiorkowska, more

Monatshefte für Chemie - Chemical Monthly > 2012 > 143 > 4 > 607-617

A series of novel S-esters of 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid and S,S′-diesters of (4-nitrobenzoyl)carbonohydrazonodithioic acid were synthesized by reaction of 4-nitrobenzohydrazide and N-methyl-4-nitrobenzohydrazide with carbon disulfide and alkyl halides in the presence of triethylamine. Novel 5-(4-nitrophenyl)-1,3,4-oxadiazoles were also obtained. The structures were confirmed by...

article

Synthesis and structural investigation of some pyrimido[5,4-c]quinolin-4(3H)-one derivatives with a long-chain arylpiperazine moiety as potent 5-HT1A/2A and 5-HT7 receptor ligands

Wieslawa Lewgowd, Andrzej J. Bojarski, Malgorzata Szczesio, Andrzej Olczak, more

European Journal of Medicinal Chemistry > 2011 > 46 > 8 > 3348-3361

A series of new pyrimido[5,4-c]quinolin-4(3H)-ones with variable length of the spacer between amide and 4-arylpiperazine moiety were prepared to further explore the role of a terminal portion in the serotonergic activity. The majority of compounds demonstrated high in vitro affinity for 5-HT _1A receptor, and moderate-to-low affinity for 5-HT _2A and 5-HT ₇ receptors. X-ray analysis,...

article

Planarity of heteroaryldithiocarbazic acid derivatives showing tuberculostatic activity. III. Mono‐ and diesters of 3‐(pyrazin‐2‐ylcarbonyl)dithiocarbazic acid

Małgorzata Szczesio, Andrzej Olczak, Jolanta Gołka, Katarzyna Gobis, more

Acta Crystallographica Section C > 67 > 7 > o235 - o240

Methyl 2‐(pyrazin‐2‐ylcarbonyl)hydrazinecarbodithioate, C₇H₈N₄OS₂, (E1), N′‐[bis(methylsulfanyl)methylidene]pyrazine‐2‐carbohydrazide, C₈H₁₀N₄OS₂, (F1), N′‐[bis(methylsulfanyl)methylidene]‐6‐methoxypyrazine‐2‐carbohydrazide, C₉H₁₂N₄O₂S₂, (F2), and methyl 1‐methyl‐2‐(pyrazin‐2‐ylcarbonyl)hydrazinecarbodithioate, C₈H₁₀N₄OS₂, (G1), can be considered as derivatives of classical (thio)amide‐type tuberculostatics,...

article

Comment on Probability density functions of the average and difference intensities of Friedel opposites by Shmueli & Flack (2010)

Andrzej Olczak

Acta Crystallographica Section A > 67 > 3 > 315 - 317

A comment is made on the discussion of probability density functions (p.d.f.s) and simulations of Friedel intensity differences in Shmueli & Flack [Acta Cryst. (2010), A66, 669675].

article

Planarity of heteroaryldithiocarbazic acid derivatives showing tuberculostatic activity. II. Crystal structures of 3‐[amino(pyrazin‐2‐yl)methylidene]‐2‐methylcarbazic acid esters

Andrzej Olczak, Małgorzata Szczesio, Jolanta Gołka, Czesława Orlewska, more

Acta Crystallographica Section C > 67 > 1 > o37 - o42

Four compounds showing moderate antituberculostatic activity have been studied to test the hypothesis that the planarity of the 2‐[amino(pyrazin‐2‐yl)methylidene]dithiocarbazate fragment is crucial for activity. N′‐Anilinopyrazine‐2‐carboximidamide, C₁₁H₁₁N₅, D1, and diethyl 2,2′‐[({[amino(pyrazin‐2‐yl)methylidene]hydrazinylidene}methylidene)bis(sulfanediyl)]diacetate, C₁₄H₁₉N₅O₄S₂, B1, maintain planarity...

article

Synthesis, structure, and tuberculostatic activity of dimethyl benzoylcarbonohydrazonodithioates

Katarzyna Gobis, Henryk Foks, Zofia Zwolska, Ewa Augustynowicz-Kopeć, more

Monatshefte für Chemie - Chemical Monthly > 2011 > 142 > 11 > 1137-1142

New dimethyl benzoylcarbonohydrazonodithioates were obtained by CS₂ addition to arylcarboxylic acid hydrazides and methylation of the formed adduct. The new derivatives were tested for their activity against Mycobacterium tuberculosis. Some compounds exhibited high activity toward sensitive and resistant strains. Graphical abstract

article

Structure of the two-subsite β-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane

Joseph S. Brunzelle, Douglas B. Jordan, Darrell R. McCaslin, Andrzej Olczak, more

Archives of Biochemistry and Biophysics > 2008 > 474 > 1 > 157-166

The three-dimensional structure of the catalytically efficient β-xylosidase from Selenomonas ruminantium in complex with competitive inhibitor 1,3-bis[tris(hydroxymethyl)methylamino]propane (BTP) was determined by using X-ray crystallography (1.3Å resolution). Most H bonds between inhibitor and protein occur within subsite −1, including one between the carboxyl group of E186 and an N group of BTP...

article

Is planarity of pyridin-2-yl- and pyrazin-2-yl-formamide thiosemicarbazones related to their tuberculostatic activity? X-ray structures of two pyrazine-2-carboxamide-N′-carbonothioyl-hydrazones

Andrzej Olczak, Marek L. Główka, Jolanta Gołka, Małgorzata Szczesio, more

Journal of Molecular Structure > 2007 > 830 > 1-3 > 171-175

Crystal structures of two title compounds and several their relatives known earlier reveal conservative and characteristic features, which may be related to their tuberculostatic activity. The molecules are predominantly planar due to conjugation through five successive bonds in the zwitterionic fragment S ⁻ –C(sp ² )–N–NH ⁺ –C(sp ² )–NH ₂ and intramolecular...

article

Stereochemistry of 1-hydroxyphosphonate–phosphate rearrangement. Retention of configuration at the phosphorus atom

Stefan Jankowski, Justyna Marczak, Andrzej Olczak, Marek L. Główka

Tetrahedron Letters > 2006 > 47 > 20 > 3341-3344

1-Hydroxyphosphonate 1 in the presence of triethylamine in acetonitrile solution undergoes irreversible rearrangement to phosphate 2 and reversible retro-phospho-aldol (retro-Abramov) reaction. The X-ray structures for 1 and 2 revealed that the phosphonate–phosphate rearrangement occurs with retention of configuration at the phosphorus atom.

article

Planarity of N′-(amino-2-pyridylmethylene)-hydrazide carbodithioic acid frame and crystal structure of its methyl ester dihydrate

Marek L. Główka, Dariusz Martynowski, Andrzej Olczak, Czesława Orlewska, more

Journal of Chemical Crystallography > 2005 > 35 > 6 > 477-480

The title compound exists in a dipolar form both in the solvent-free and in the dihydrate crystal. Unit cell dimensions: 23.303(5), 7.3100(10), 15.030(3) Å, β = 101.78(3)^∘; space group C2/c (monoclinic) with Z = 8. The molecule is flat due to extended conjugation in the central N=C(pyr)–N(3)H–N=C–S– fragment and three assisted intramolecular hydrogen bonds, one of them between the pyridine N atom...

article

Intramolecular hydrogen bond between 4-oxo and 3-carboxylic groups in quinolones and their analogs. Crystal structures of 7-methyl- and 6-fluoro-1,4-dihydro-4-oxocinnoline-3-carboxylic acids

Marek L. Gl̷ówka, Dariusz Martynowski, Andrzej Olczak, Joanna Bojarska, more

Journal of Molecular Structure > 2003 > 658 > 1-2 > 43-50

Crystal structures of two cinnoline analogs of quinolones and statistics on quinolones molecular forms observed in the crystal state have been determined. It has been shown that common quinolones may be divided into two main types, depending on presence of proton acceptor, usually aliphatic amine group, capable of protonation under mild conditions. Quinolones lacking amine group or having one(s) bound...

article

Structural consequences of hindered rotation of tolyl substituent in 2,2,4,4,6,6-hexamethyl-1,3,5-tritolylcyclotrisilazanes. Crystal structures of o-, m- and p-tolyl derivatives

Marek L. Gl̷ówka, Andrzej Olczak, Dariusz Martynowski, Krystyna Kozl̷owska, more

Journal of Molecular Structure > 2002 > 613 > 1-3 > 145-151

Crystal structures of 2,2,4,4,6,6-hexamethyl-1,3,5-tritolylcyclotrisilazanes revealed similar arrangements of molecules and statistical disorder in ortho and meta derivatives. Tolyl rings are nearly perpendicular to the mean cyclotrisilazane ring, which is in a boat or a distorted boat conformation. Due to asymmetry of o- and m-tolyl rings and their hindered rotation, two distinct rotamers of the...

article

Structure of 1,4-dihydro-1-ethyl-4-iminecinnoline-3-carboxylic acids, classical isosters of quinolone antibacterials: Crystal structures of hydrochlorides of 7-chloro and 7-methyl derivatives

Marek L. Główka, Dariusz Martynowski, Alina Napieraj, Andrzej Olczak, more

Journal of Chemical Crystallography > 1999 > 29 > 6 > 687-693

Crystal structures of hydrochlorides of 7-chloro- and 7-methyl-4-iminecinnoline analogs of antibacterial quinolones have been determined by X-ray diffraction methods. The cell parameters for the 7-chloro (1) analog in the space group P2₁/c are a = 9.061(1), b = 19.062(1), c = 7.310(1)Å, β = 104.92(1)°, Z = 4, and D _calc = 1.569 g/cm³ and for the 7-methyl (2) analog in the space group P ...

article

Geometry of lidocaine-like molecules: 2. Crystal structures of 2-benzyl-2-(1-piperidinyl)-N-(2,6-dimethylphenyl) acetamide and its hydrochloride hemihydrate

Marek L. Główka, Andrzej Olczak

Journal of Chemical Crystallography > 1999 > 29 > 6 > 695-700

The title compounds both crystallize in the monoclinic space group P2₁ (Z = 4), with a = 12.574(1), b = 9.653(1) c = 16.483(1) Å, and β = 91.84(1)° for the free base and a = 10.991(2), b = 16.864(3), c = 12.030(2) Å, β = 99.35(3)° for the hydrochloride. The most important factors affecting conformation of the molecules are: ortho-substitution of the benzene ring in the acetanilide system and substitution...

Filter options

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Andrzej Olczak

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options