Search results for: Katarzyna Wójcik-Pszczoła

Items from 1 to 7 out of 7 results

article

Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug—Minireview of in vitro studies

Paulina Koczurkiewicz, Katarzyna Klaś, Karolina Grabowska, Kamil Piska, more

Phytotherapy Research > 33 > 9 > 2141 - 2151

Triterpene saponins (saponosides) are found in higher plants and display a wide range of biological and pharmacological activities. The antitumor effects of saponins have been proved by their cytotoxic, cytostatic, proapoptotic, and anti‐invasive effects in many cellular models. Saponins hold great potential for being developed into chemopreventive and chemotherapeutic drugs. A promising way of reducing...

article

Correction to: Fibroblast-to-myofibroblast transition in bronchial asthma

Marta Michalik, Katarzyna Wójcik-Pszczoła, Milena Paw, Dawid Wnuk, more

Cellular and Molecular Life Sciences > 2019 > 76 > 1 > 209-209

In the original publication, funding information was inadvertently omitted.

article

Fibroblast-to-myofibroblast transition in bronchial asthma

Marta Michalik, Katarzyna Wójcik-Pszczoła, Milena Paw, Dawid Wnuk, more

Cellular and Molecular Life Sciences > 2018 > 75 > 21 > 3943-3961

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling plays a significant role. This phenomenon is related to enhanced proliferation of airway smooth muscle cells, elevated extracellular matrix protein secretion and an increased number of myofibroblasts. Phenotypic fibroblast-to-myofibroblast transition represents one of the primary mechanisms by which myofibroblasts...

article

Piperlongumine (piplartine) as a lead compound for anticancer agents – Synthesis and properties of analogues: A mini-review

Kamil Piska, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz, Katarzyna Wójcik-Pszczoła, more

European Journal of Medicinal Chemistry > 2018 > 156 > C > 13-20

Piperlongumine, also known as piplartine, is an amide alkaloid of Piper longum L. (long piper), a medical plant known from Ayurvedic medicine. Although was discovered well over fifty years ago, its pharmacological properties have been uncovered in the past decade. In particular, piperlongumine has been most extensively studied as a potential anticancer agent. Piperlongumine has exhibited cytotoxicity...

article

Biotransformation of 4‐fluoro‐N‐(1‐{2‐[(propan‐2‐yl)phenoxy]ethyl}‐8‐azabicyclo[3.2.1]octan‐3‐yl)‐benzenesulfonamide, a novel potent 5‐HT₇ receptor antagonist with antidepressant‐like and anxiolytic properties: In vitro and in silico approach

Karolina Słoczyńska, Katarzyna Wójcik‐Pszczoła, Vittorio Canale, Paweł Żmudzki, more

Journal of Biochemical and Molecular Toxicology > 32 > 5 > n/a - n/a

The aim of the study was to investigate the metabolism of 4‐fluoro‐N‐(1‐{2‐[(propan‐2‐yl)phenoxy]ethyl}‐8‐azabicyclo[3.2.1]octan‐3‐yl)‐benzenesulfonamide (PZ‐1150), a novel 5‐HT₇ receptor antagonist with antidepressant‐like and anxiolytic properties, by the following three ways: in vitro with microsomes; in vitro employing Cunninghamella echinulata, and in silico using MetaSite. Biotransformation...

article

Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents

Kamil Piska, Paulina Koczurkiewicz, Adam Bucki, Katarzyna Wójcik-Pszczoła, more

Investigational New Drugs > 2017 > 35 > 3 > 375-385

Summary Anthracycline antibiotics (ANT), such as doxorubicin or daunorubicin, are a class of anticancer drugs that are widely used in oncology. Although highly effective in cancer therapy, their usefulness is greatly limited by their cardiotoxicity. Possible mechanisms of ANT cardiotoxicity include their conversion to secondary alcohol metabolites (i.e. doxorubicinol, daunorubicinol) catalyzed by...

article

Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition

Katarzyna Wójcik-Pszczoła, Kinga Hińcza, Dawid Wnuk, Dominika Kądziołka, more

Acta Biochimica Polonica > 2016 > 63 > 3 > 437-442

Bronchial asthma is characterized by persistent airway inflammation and airway wall remodeling. Among many different cells and growth factors triggering changes in bronchi structure, transforming growth factor β1-induced fibroblast to myofibroblast transition is believed to be very important. The aim of this study was to evaluate whether theophylline (used in asthma therapy) and two other methylxanthines...

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Search results for: Katarzyna Wójcik-Pszczoła

Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug—Minireview of in vitro studies

Correction to: Fibroblast-to-myofibroblast transition in bronchial asthma

Fibroblast-to-myofibroblast transition in bronchial asthma

Piperlongumine (piplartine) as a lead compound for anticancer agents – Synthesis and properties of analogues: A mini-review

Biotransformation of 4‐fluoro‐N‐(1‐{2‐[(propan‐2‐yl)phenoxy]ethyl}‐8‐azabicyclo[3.2.1]octan‐3‐yl)‐benzenesulfonamide, a novel potent 5‐HT7 receptor antagonist with antidepressant‐like and anxiolytic properties: In vitro and in silico approach

Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents

Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition

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Biotransformation of 4‐fluoro‐N‐(1‐{2‐[(propan‐2‐yl)phenoxy]ethyl}‐8‐azabicyclo[3.2.1]octan‐3‐yl)‐benzenesulfonamide, a novel potent 5‐HT₇ receptor antagonist with antidepressant‐like and anxiolytic properties: In vitro and in silico approach