Search results for: Malgorzata Polz-Dacewicz

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Aktywność przeciwdrobnoustrojowa ekstraktów z robinii akacjowej (Robinia pseudoacacia L.) otrzymanych w warunkach nadkrytycznych

Agnieszka Grzegorczyk, Anna Biernasiuk, Magdalena Iwan, Agnieszka Korga, more

Przemysł Chemiczny > 2019 > T. 98, nr 6 > 989-992

Badano aktywność przeciwbakteryjną i przeciwgrzybiczą wyciągów otrzymanych metodą ekstrakcji ditlenkiem węgla w stanie nadkrytycznym z młodych pędów Robinia pseudoacacia L.uzyskanych z udziałem czystego CO₂ (ekstrakty CO₂) i z udziałem wody jako współrozpuszczalnika (ekstrakty CO₂+H₂O, 1% mas.). Oznaczano najmniejsze stężenie hamujące (MIC), najmniejsze stężenie bakteriobójcze (MBC) oraz najmniejsze...

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Design, synthesis, structure elucidation and in vitro antiviral and antimicrobial evaluation

Anna Pachuta-Stec, Barbara Rajtar, Anna Biernasiuk, Zbigniew Karczmarzyk, more

Journal of the Iranian Chemical Society > 2018 > 15 > 4 > 839-853

In this study, we described the synthesis of the derivatives of thiosemicarbazide, dicarboximide, 1,2,4-triazole-5-thione and 4-oxo-1,3-thiazolidine. Two different dicarboxylic acid anhydrides reacted with 4-substituted-3-thiosemicarbazide, and derivatives of thiosemicarbazide and dicarboximide were obtained. Next, cyclization reaction of dicarboximide derivatives in alkaline media was used to prepare...

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Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections

Barbara Rajtar, Krystyna Skalicka-Woźniak, Łukasz Świątek, Agnieszka Stec, more

Food and Chemical Toxicology > 2017 > 109 > P2 > 1026-1031

The dichloromethane extract from fruits of Angelica archangelica L. was separated by the modern high-performance countercurrent chromatography (HPCCC). The extract and five pure compounds: xanthotoxin, bergapten, imperatorin, phellopterin and isoimperatorin, and the mixture of imperatorin and phellopterin, have been studied as the potential antiviral agents against Herpes simplex virus type l and...

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Biological activity and safety profile of the essential oil from fruits of Heracleum mantegazzianum Sommier & Levier (Apiaceae)

Krystyna Skalicka-Woźniak, Agnieszka Grzegorczyk, Łukasz Świątek, Magdalena Walasek, more

Food and Chemical Toxicology > 2017 > 109 > P2 > 820-826

A composition of essential oils obtained from Heracleum mantegazzianum (Apiaceae) was examined using a GC-MS method. n-Octyl acetate (19.92%), n-hexyl-2-methylbutanoate (10.84%), n-octanol (10.13%), n-octyl butanoate (8.88%), n-octyl-2-methylbutanoate (8.01%), n-hexyl acetate (7.11%), n-octyl isobutanoate (5.5%) and n-hexyl isobutanoate (5.43%) were the main compounds. The high-performance counter-current...

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Serum EBV antibodies and LMP-1 in Polish patients with oropharyngeal and laryngeal cancer

Sylwia Fołtyn, Małgorzata Strycharz-Dudziak, Bartłomiej Drop, Anastazja Boguszewska, more

Infectious Agents and Cancer > 2017 > 12 > 1 > 1-6

Background The association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polish patients with oropharyngeal and laryngeal cancer compared to 40 healthy individuals. Methods Frozen tumor tissue fragments were tested using nested PCR assay for EBV DNA detection...

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Carrot seed essential oil—Source of carotol and cytotoxicity study

Elwira Sieniawska, Łukasz Świątek, Barbara Rajtar, Ewelina Kozioł, more

Industrial Crops and Products > 2016 > 92 > C > 109-115

Carrot seed essential oil is a common fragrance component in cosmetics and perfumes and a flavor ingredient in different categories of food products. It is also a major source of sesquiterpene alcohol carotol. In this work we aimed to compare carotol content in commercially available (Moroccan and French) and hydrodistilled (Polish) wild carrot seed essential oils (Daucus carota L. ssp. carota) and...

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Salivary and serum IL-10, TNF-α, TGF-β, VEGF levels in oropharyngeal squamous cell carcinoma and correlation with HPV and EBV infections

Małgorzata Polz-Dacewicz, Małgorzata Strycharz-Dudziak, Jakub Dworzański, Agnieszka Stec, more

Infectious Agents and Cancer > 2016 > 11 > 1 > 1-8

Background Each year approximately 6,000 new cases of head and neck cancer are registered in Poland. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been associated with tumour formation. Cytokines have been shown to play an important role both in inflammation and carcinogenesis and they can be detected in saliva and serum with ELISA assays. Salivary biomarkers may be used as markers...

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Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids

Tomasz Plech, Barbara Kaproń, Agata Paneth, Urszula Kosikowska, more

European Journal of Medicinal Chemistry > 2015 > 97 > Complete > 94-103

A series of 1,2,4-triazole-based compounds was designed as potential antibacterial agents using molecular hybridization approach. The target compounds (23–44) were synthesized by Mannich reaction of 1,2,4-triazole-3-thione derivatives with ciprofloxacin (CPX) and formaldehyde. Their potent antibacterial effect on Gram-positive bacteria was accompanied by similarly strong activity against Gram-negative...

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Prevalence of Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in oral and oropharyngeal squamous cell carcinoma in south-eastern Poland

Dorota Polz-Gruszka, Kamal Morshed, Agnieszka Stec, Małgorzata Polz-Dacewicz

Infectious Agents and Cancer > 2015 > 10 > 1 > 1-7

Objective The aim of this study was to analyze the prevalence of HPV and EBV in oral and oropharyngeal squamous cell carcinoma in south-eastern Poland. The correlation between viral infection, OSCC, alcohol use, tobacco smoking, demographic data (gender, age, place of residence), anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. Methods...

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Prevalence of Polyomaviruses in Polish patients

Marzena Badura, Jakub Dworzanski, Anna Polz, Malgorzata Polz-Dacewicz

Current Issues in Pharmacy and Medical Sciences > 2014 > 27 > 4 > 250-252

The aim of our study was to investigate the prevalence of new polyomaviruses KIPyV and WUPyV in the Polish population in the Lublin region. In it, we demonstrated that the prevalence of this viruses is low - 1.1% WU and 3.4% KI. The viruses are most commonly detected in materials from the respiratory tract, both in children and the elderly. Polyomaviruses KI and WU in co-infection, often occur with...

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Human Papillomavirus (HPV) – Structure, epidemiology and pathogenesis

Kamal Morshed, Dorota Polz-Gruszka, Marcin Szymański, Małgorzata Polz-Dacewicz

Otolaryngologia Polska > 2014 > 68 > 5 > 213-219

The number of cancers is constantly increasing. An important role in the etiology of many of them is played by the viral factor, by oncogenic viruses, such as the Human Papillomavirus. The article shows current epidemiological situation and describes the structure of the virus and modes of transmission. It also explains the role of HPV infection in cancer with particular emphasis on oropharynx and...

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The prevalence of enteroviruses that cause respiratory infections in patients with influenzavirus A/H1N1 hospitalized in the Lublin province

Adrian Jarzynski, Agata Dubas, Malgorzata Polz-Dacewicz

Current Issues in Pharmacy and Medical Sciences > 2014 > 27 > 3 > 199-201

Viruses that cause respiratory tract infections are the most common agents of infectious diseases in humans throughout the world. A virus that infects the respiratory system, may induce various clinical symptoms. What is more, the same symptoms may be caused by different viruses. The aim of the study was to analyze the prevalence of enteroviruses that cause respiratory infections in patients with...

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Prevalence of hepatitis A virus antibodies in Central-Eastern Poland – a comparative study (1990-2012)

Dariusz Pachnia, Dorota Polz-Gruszka, Pawel Macielag, Malgorzata Polz-Dacewicz

Current Issues in Pharmacy and Medical Sciences > 2014 > 27 > 1 > 17-19

Hepatitis A virus (HAV) is an hepatotropic human picornavirus that is associated only with acute infection of liver. This pathogen is mainly transmitted through the faecal-oral route, by person-to-person contact, and also contaminated drinking water and food. This reserach presenting the comparative seroepidemiological study (1990/1999/2012) on HAV infection was carried out in population from south-eastern...

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Prevalence of hepatitis A virus antibodies in Central-Eastern Poland – a comparative study (1990-2012)

Dariusz Pachnia, Dorota Polz-Gruszka, Pawel Macielag, Malgorzata Polz-Dacewicz

Current Issues in Pharmacy and Medical Sciences > 2014 > 27 > 1 > 17-19

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Inhibitory effect of N-ethyl-3-amino-5-oxo-4-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide on Haemophilus spp. planktonic or biofilm-forming cells

Urszula Kosikowska, Anna Malm, Monika Pitucha, Barbara Rajtar, more

Medicinal Chemistry Research > 2014 > 23 > 2 > 1057-1066

During this study, we have investigated in vitro activity of N-substituted-3-amino-5-oxo-4-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide derivatives with N-ethyl, N-(4-metoxyphenyl) and N-cyclohexyl substituents against Gram-negative Haemophilus influenzae and H. parainfluenzae bacteria. A spectrophotometric assay was used in order to determine the bacterial growth and biofilm formation using a...

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Cytotoxicity, antioxidant activity and an effect on CYP3A4 and CYP2D6 of Mutellina purpurea L. extracts

Elwira Sieniawska, Tomasz Baj, Jarosław Dudka, Renata Gieroba, more

Food and Chemical Toxicology > 2013 > 52 > Complete > 188-192

Mutellina purpurea is an aromatic Apiaceae plant known as Alpine lovage. Its polar extracts consist of phenolic acids, tannins and flavonoids. The cytotoxic effect of methanolic and aqueous extracts from M. purpurea was studied on the most frequently used cell lines: HeLa and BHK-21. Taking into account that the natural products are often used with other medicines there is a risk of reciprocal interaction...

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Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria

Tomasz Plech, Monika Wujec, Urszula Kosikowska, Anna Malm, more

European Journal of Medicinal Chemistry > 2013 > 60 > C > 128-134

A series of novel 1,2,4-triazole-ciprofloxacin hybrids was designed, synthesised and evaluated in vitro against drug-susceptible and drug-resistant bacteria. A significant part of the compounds obtained showed antibacterial activity higher than the activity of ciprofloxacin, both towards Gram-positive and Gram-negative species. Despite relatively small number of synthesised derivatives, it was possible...

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Synthesis and Antibacterial Activity of Novel Fused 1,3‐Thiazoles and 1,3‐Thiazines Incorporating a 2,4‐Dihydroxyphenyl Residue

Joanna Matysiak, Renata Los, Anna Malm, Monika M. Karpińska, more

Archiv der Pharmazie > 345 > 4 > 302 - 313

In an attempt to find a new class of antimicrobial agents, a series of benzothiazoles, 1,3‐thiazolo[5,4‐b]pyridines, 4H‐3,1‐benzothiazines, naphtho[2,3‐d][1,3]thiazole‐4,9‐diones and other related compounds containing a 2,4‐dihydroxyphenyl moiety were prepared. They were obtained via the reaction of aryl‐modified sulfinyl[bis(2,4‐dihydroxyphenylmethanethione)]s with appropriate commercial chemical...

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Ekspresja białka P53 i obecności wirusa brodawczaka ludzkiego (HPV) w raku krtani. Korelacja pomiędzy obecnością wirusa brodawczaka ludzkiego i ekspresją białka P53

Kamal Morshed, Marcin Szymański, Małgorzata Polz-Dacewicz, Marek Zadrożniak, more

Otolaryngologia Polska > 2011 > 65 > 3 Supplement > 19-25

The aim of this study was to determine the expression of p53 and prevalence of HPV infection in laryngeal squamous cell carcinoma, and to analyze relationship between HPV infection and P53 expression.The immunohistochemistry (IHC) staining was used to detect the HPV prevalence and P53 expression in 130 specimens of laryngeal squamous cell carcinoma.P53 nuclear expression was detected in 83 (63.8%)...

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Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation

Kamal Morshed, Małgorzata Polz-Dacewicz, Marcin Szymański, Dorota Polz

European Archives of Oto-Rhino-Laryngology > 2008 > 265 > 1 > 89-96

The aim of the study was to determine the prevalence and genotypes of HPV infection in laryngeal cancer specimens, normal mucosa obtained from the surgical margin and laryngeal nodules using a novel high sensitive and specific SPF₁₀ HPV DNA test, PCR/DEIA method and INNO-LiPA genotyping assay. The correlation between HPV presence and clinico-pathological features was analyzed. Tissue samples were...

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Search results for: Malgorzata Polz-Dacewicz

Aktywność przeciwdrobnoustrojowa ekstraktów z robinii akacjowej (Robinia pseudoacacia L.) otrzymanych w warunkach nadkrytycznych

Design, synthesis, structure elucidation and in vitro antiviral and antimicrobial evaluation

Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections

Biological activity and safety profile of the essential oil from fruits of Heracleum mantegazzianum Sommier & Levier (Apiaceae)

Serum EBV antibodies and LMP-1 in Polish patients with oropharyngeal and laryngeal cancer

Carrot seed essential oil—Source of carotol and cytotoxicity study

Salivary and serum IL-10, TNF-α, TGF-β, VEGF levels in oropharyngeal squamous cell carcinoma and correlation with HPV and EBV infections

Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids

Prevalence of Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in oral and oropharyngeal squamous cell carcinoma in south-eastern Poland

Prevalence of Polyomaviruses in Polish patients

Human Papillomavirus (HPV) – Structure, epidemiology and pathogenesis

The prevalence of enteroviruses that cause respiratory infections in patients with influenzavirus A/H1N1 hospitalized in the Lublin province

Prevalence of hepatitis A virus antibodies in Central-Eastern Poland – a comparative study (1990-2012)

Prevalence of hepatitis A virus antibodies in Central-Eastern Poland – a comparative study (1990-2012)

Inhibitory effect of N-ethyl-3-amino-5-oxo-4-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide on Haemophilus spp. planktonic or biofilm-forming cells

Cytotoxicity, antioxidant activity and an effect on CYP3A4 and CYP2D6 of Mutellina purpurea L. extracts

Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria

Synthesis and Antibacterial Activity of Novel Fused 1,3‐Thiazoles and 1,3‐Thiazines Incorporating a 2,4‐Dihydroxyphenyl Residue

Ekspresja białka P53 i obecności wirusa brodawczaka ludzkiego (HPV) w raku krtani. Korelacja pomiędzy obecnością wirusa brodawczaka ludzkiego i ekspresją białka P53

Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation

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