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Pre-clinical studies showed that Doxorubicin-loaded hollow nanoshells (Dox-PEG@HAuNS) increases the efficacy of photothermal ablation (PTA) by not only mediating efficient PTA but also through chemotherapy, and therefore may have potential utility for local anti-cancer therapy. In this study, we mapped the release of Doxorubicin, and increase in temperature mediated by Dox-PEG@HAuNS after near-infrared...
Irreversible electroporation (IRE) is a new non-thermal ablation technique. It creates both a central ablation zone and a surrounding sub-lethal region. Cancer cells within the sub-lethal region may survive and cause relapse of tumor. The electric field in sub-lethal regions may be sufficient to induce the intracellular delivery of therapeutic agents. Nanoparticles loaded with small-interfering RNA...
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