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Semenogelins and eppin are seminal plasma proteins that form a complex and inhibit sperm motility. However, the role of these proteins in prostate cancer is poorly understood. We immunohistochemically stained for semenogelins I and II and eppin in 291 radical prostatectomy specimens. We then evaluated the association between their expressions in nuclei, cytoplasms, or intraluminal secretions of benign/high-grade...
BACKGROUNDLittle is known about the role of semenogelins, seminal plasma proteins that play critical roles in semen clotting and subsequent liquefaction in the presence of zinc and prostate‐specific antigen, in human malignancies.
METHODSWe investigated the expression of semenogelins in four human prostate cancer lines by RT‐PCR and Western blotting as well as in 70 radical prostatectomy specimens...
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