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Manege frei! Überraschend komplexe molekulare „Akrobatiken“ werden im Mechanismus der Ligationsreaktion zwischen α‐Ketosäuren und Alkylhydroxylaminen beobachtet. Diese bemerkenswerte Reaktion kann schon jetzt für die chemoselektive Verknüpfung von großen, ungeschützten Peptidfragmenten genutzt werden, mit der Aufklärung des Mechanismus wurde nun die Grundlage für die Anwendung auf größere und komplexere...
Three‐ring circus! Surprisingly complex molecular acrobatics are observed in the mechanism of the α‐ketoacid–hydroxylamine amide‐forming ligation reaction. Although this remarkable reaction can already be used for the chemoselective union of large, unprotected peptide fragments the elucidated mechanism provides important clues to extending its application to larger and more complex biological targets.
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