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Spinal fusion will continue to be an important part of the surgical treatment of spinal pathology for the foreseeable future. Traditional challenges to successful spinal fusion surgery include autograft donor site morbidity and pseudoarthrosis. Recent advances in the understanding of the biology of bone formation have allowed the development of therapeutic biologics. Although recombinant bone morphogenetic...
Purpose of study: Although several bone morphogenic proteins (BMPs) have been shown to enhance bone healing and spinal fusion, the optimal BMPs or combination of BMPs to promote fusion are unknown. This study was designed to comprehensively elucidate the distinct and potentially synergistic osteogenic activity of 14 types of BMPs at various stages of osteogenesis.Methods used: Recombinant adenoviruses...
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