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Background and PurposeThe neuropeptide 26RFa and its cognate receptor GPR103 are involved in the control of food intake and bone mineralization. Here, we have tested, experimentally, the predicted ligand‐receptor interactions by site‐directed mutagenesis of GPR103 and designed point‐substituted 26RFa analogues.
Experimental ApproachUsing the X‐ray structure of the β2‐adrenoceptor, a 3‐D molecular...
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