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Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure–activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for...
Valyl-tRNA synthetase (ValRS) strictly discriminates the cognate L-valine from the larger L-isoleucine and the isosteric L-threonine by the tRNA-dependent ''double sieve'' mechanism. In this study, we determined the 2.9 Å crystal structure of a complex of Thermus thermophilus ValRS, tRNA Val , and an analog of the Val-adenylate intermediate. The analog is bound in a pocket, where...
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