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Three types of mono- and disaccharides 3a,b, 4a–c, 5, and some chaetomellic acid A analogs 6 and 42–44 were synthesized as potential inhibitors of the transglycosylase activity of penicillin-binding protein 1b (PBP1b), a key bacterial enzyme responsible for the formation of the polysaccharide backbone of peptidoglycan as well as for cross-linking of its peptide portions. The target compounds combine...
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