Nelson B. Cole

article

Oxidative stress causes reversible changes in mitochondrial permeability and structure

Nelson B. Cole, Mathew P. Daniels, Rodney L. Levine, Geumsoo Kim

Experimental Gerontology > 2010 > 45 > 7-8 > 596-602

Mitochondria are a primary source as well a principal target of reactive oxygen species within cells. Using immunofluorescence microscopy, we have found that a number of mitochondrial matrix proteins are normally undetectable in formaldehyde-fixed cells permeabilized with the cholesterol-binding detergent saponin. However, exogenous or endogenous oxidative stress applied prior to fixation altered...

article

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

Nelson B. Cole, Diane DiEuliis, Paul Leo, Drake C. Mitchell, more

Experimental Cell Research > 2008 > 314 > 10 > 2076-2089

Mitochondrial dysfunction plays a central role in the selective vulnerability of dopaminergic neurons in Parkinson's disease (PD) and is influenced by both environmental and genetic factors. Expression of the PD protein α-synuclein or its familial mutants often sensitizes neurons to oxidative stress and to damage by mitochondrial toxins. This effect is thought to be indirect, since little evidence...

article

Acyl-CoA Synthetase Activity Links Wild-Type but Not Mutant α-Synuclein to Brain Arachidonate Metabolism ^†

Mikhail Y. Golovko, Thad A. Rosenberger, Søren Feddersen, Nelson B. Cole, more

Biochemistry > 2006 > 45 > 22 > 6956 - 6966

article

α-Synuclein Gene Deletion Decreases Brain Palmitate Uptake and Alters the Palmitate Metabolism in the Absence of α-Synuclein Palmitate Binding ^†

Mikhail Y. Golovko, Nils J. Faergeman, Nelson B. Cole, Paula I. Castagnet, more

Biochemistry > 2005 > 44 > 23 > 8251 - 8259

article

The cell biology of α-synuclein

Nelson B. Cole, Diane D. Murphy

NeuroMolecular Medicine > 2002 > 1 > 2 > 95-109

Parkinson’s disease (PD) is the most common neurodegenerative motor disorder, marked by chronic progressive loss of neurons in the substantia nigra, thereby damaging purposeful control of movement. For decades, it was believed that PD was caused solely by environmental causes. However, the discovery of genetic factors involved in PD has revolutionized our attempts to understand the disease’s pathology...

article

Golgi Membranes Are Absorbed into and Reemerge from the ER during Mitosis

Kristien J.M Zaal, Carolyn L Smith, Roman S Polishchuk, Nihal Altan, more

Cell > 1999 > 99 > 6 > 589-601

Quantitative imaging and photobleaching were used to measure ER/Golgi recycling of GFP-tagged Golgi proteins in interphase cells and to monitor the dissolution and reformation of the Golgi during mitosis. In interphase, recycling occurred every 1.5 hr, and blocking ER egress trapped cycling Golgi enzymes in the ER with loss of Golgi structure. In mitosis, when ER export stops, Golgi proteins redistributed...

article

Building a secretory apparatus: role of ARF1/COPI in Golgi biogenesis and maintenance

J. Lippincott-Schwartz, Nelson B. Cole, Julie G. Donaldson

Histochemistry and Cell Biology > 1998 > 109 > 5/6 > 449-462

AbstractThe secretory apparatus within all eukaryotic cells comprises a dynamic membrane system with bidirectional membrane transport pathways and overlapping compartmental boundaries. Membrane traffic and organelle biogenesis/maintenance are fundamentally linked within this system, with perturbations in membrane traffic quickly leading to changes in organelle structure and identity. Dissection of...

INFONA - science communication portal

Search results for: Nelson B. Cole

Oxidative stress causes reversible changes in mitochondrial permeability and structure

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

Acyl-CoA Synthetase Activity Links Wild-Type but Not Mutant α-Synuclein to Brain Arachidonate Metabolism ^†

α-Synuclein Gene Deletion Decreases Brain Palmitate Uptake and Alters the Palmitate Metabolism in the Absence of α-Synuclein Palmitate Binding ^†

The cell biology of α-synuclein

Golgi Membranes Are Absorbed into and Reemerge from the ER during Mitosis

Building a secretory apparatus: role of ARF1/COPI in Golgi biogenesis and maintenance

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Nelson B. Cole

Oxidative stress causes reversible changes in mitochondrial permeability and structure

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

Acyl-CoA Synthetase Activity Links Wild-Type but Not Mutant α-Synuclein to Brain Arachidonate Metabolism †

α-Synuclein Gene Deletion Decreases Brain Palmitate Uptake and Alters the Palmitate Metabolism in the Absence of α-Synuclein Palmitate Binding †

The cell biology of α-synuclein

Golgi Membranes Are Absorbed into and Reemerge from the ER during Mitosis

Building a secretory apparatus: role of ARF1/COPI in Golgi biogenesis and maintenance

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options

Acyl-CoA Synthetase Activity Links Wild-Type but Not Mutant α-Synuclein to Brain Arachidonate Metabolism ^†

α-Synuclein Gene Deletion Decreases Brain Palmitate Uptake and Alters the Palmitate Metabolism in the Absence of α-Synuclein Palmitate Binding ^†